Open Access
Ru(III) Complexes with Lonidamine-Modified Ligands
Ilya A. Shutkov
1
,
Yulia N Okulova
1
,
Vladimir Yu. Tyurin
1
,
Denis A Babkov
2
,
А. А. Спасов
2
,
Yulia A. Gracheva
1
,
Claudia Schmidt
3
,
Kirill I. Kirsanov
4, 5
,
Alexander A. Shtil
4
,
Olga M Redkozubova
6
,
E. F. Shevtsova
7
,
Elena R. Milaeva
1
,
Ingo Ott
3
,
6
Neurobotics, Zelenograd pas. 4922, 4-2-477, 124498 Moscow, Russia
|
Publication type: Journal Article
Publication date: 2021-12-15
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
34948263
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor of aerobic glycolysis in cancer cells) was described. Redox properties of Ru(III) complexes were characterized by cyclic voltammetry. An easy reduction suggested a perspective for these agents as their whole mechanism of action seems to be based on activation by metal atom reduction. New compounds demonstrated a more pronounced antiproliferative potency than the parental drug; individual new agents were more cytotoxic than cisplatin. Stability studies showed an increase in the stability of complexes along with the linker length. A similar trend was noted for antiproliferative activity, cellular uptake, apoptosis induction, and thioredoxin reductase inhibition. Finally, at concentrations that did not alter water solubility, the selected new complex evoked no acute toxicity in Balb/c mice.
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17
Total citations:
17
Citations from 2024:
8
(47.06%)
Cite this
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MLA
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GOST
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Shutkov I. A. et al. Ru(III) Complexes with Lonidamine-Modified Ligands // International Journal of Molecular Sciences. 2021. Vol. 22. No. 24. p. 13468.
GOST all authors (up to 50)
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Shutkov I. A., Okulova Y. N., Tyurin V. Y., Sokolova E. V., Babkov D. A., Спасов А. А., Gracheva Y. A., Schmidt C., Kirsanov K. I., Shtil A. A., Redkozubova O. M., Shevtsova E. F., Milaeva E. R., Ott I., Nazarov A. A. Ru(III) Complexes with Lonidamine-Modified Ligands // International Journal of Molecular Sciences. 2021. Vol. 22. No. 24. p. 13468.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms222413468
UR - https://doi.org/10.3390/ijms222413468
TI - Ru(III) Complexes with Lonidamine-Modified Ligands
T2 - International Journal of Molecular Sciences
AU - Shutkov, Ilya A.
AU - Okulova, Yulia N
AU - Tyurin, Vladimir Yu.
AU - Sokolova, Elena V.
AU - Babkov, Denis A
AU - Спасов, А. А.
AU - Gracheva, Yulia A.
AU - Schmidt, Claudia
AU - Kirsanov, Kirill I.
AU - Shtil, Alexander A.
AU - Redkozubova, Olga M
AU - Shevtsova, E. F.
AU - Milaeva, Elena R.
AU - Ott, Ingo
AU - Nazarov, Alexey A.
PY - 2021
DA - 2021/12/15
PB - MDPI
SP - 13468
IS - 24
VL - 22
PMID - 34948263
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Shutkov,
author = {Ilya A. Shutkov and Yulia N Okulova and Vladimir Yu. Tyurin and Elena V. Sokolova and Denis A Babkov and А. А. Спасов and Yulia A. Gracheva and Claudia Schmidt and Kirill I. Kirsanov and Alexander A. Shtil and Olga M Redkozubova and E. F. Shevtsova and Elena R. Milaeva and Ingo Ott and Alexey A. Nazarov},
title = {Ru(III) Complexes with Lonidamine-Modified Ligands},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {MDPI},
month = {dec},
url = {https://doi.org/10.3390/ijms222413468},
number = {24},
pages = {13468},
doi = {10.3390/ijms222413468}
}
Cite this
MLA
Copy
Shutkov, Ilya A., et al. “Ru(III) Complexes with Lonidamine-Modified Ligands.” International Journal of Molecular Sciences, vol. 22, no. 24, Dec. 2021, p. 13468. https://doi.org/10.3390/ijms222413468.