Open Access
International Journal of Molecular Sciences, volume 23, issue 11, pages 6056
Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice
Averina Olga A
1, 2
,
Laptev Ivan G
1
,
Emelianova Mariia A
3
,
Permyakov Oleg A
2
,
Mariasina Sofia
2
,
Nikiforova Alyona I
4
,
Manskikh Vasily N
1
,
Grigorieva Olga O
2
,
Bolikhova Anastasia K
5
,
Kalabin Gennady A
6
,
Dontsova Olga A.
1, 3, 7, 8
,
Sergiev Petr V.
1, 2, 3, 7
6
Publication type: Journal Article
Publication date: 2022-05-27
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
35682734
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Mitochondrial translation is a unique relic of the symbiotic origin of the organelle. Alterations of its components cause a number of severe human diseases. Hereby we report a study of mice devoid of Mettl15 mitochondrial 12S rRNA methyltransferase, responsible for the formation of m4C839 residue (human numbering). Homozygous Mettl15−/− mice appeared to be viable in contrast to other mitochondrial rRNA methyltransferase knockouts reported earlier. The phenotype of Mettl15−/− mice is much milder than that of other mutants of mitochondrial translation apparatus. In agreement with the results obtained earlier for cell cultures with an inactivated Mettl15 gene, we observed accumulation of the RbfA factor, normally associated with the precursor of the 28S subunit, in the 55S mitochondrial ribosome fraction of knockout mice. A lack of Mettl15 leads to a lower blood glucose level after physical exercise relative to that of the wild-type mice. Mettl15−/− mice demonstrated suboptimal muscle performance and lower levels of Cox3 protein synthesized by mitoribosomes in the oxidative soleus muscles. Additionally, we detected decreased learning capabilities in the Mettl15−/− knockout mice in the tests with both positive and negative reinforcement. Such properties make Mettl15−/− knockout mice a suitable model for mild mitochondriopathies.
Citations by journals
|
1
|
|
|
Stem Cell Reviews and Reports
|
Stem Cell Reviews and Reports
1 publication, 33.33%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 33.33%
|
|
Cell Discovery
|
Cell Discovery
1 publication, 33.33%
|
|
1
|
Citations by publishers
|
1
2
|
|
|
Springer Nature
|
Springer Nature
2 publications, 66.67%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 33.33%
|
|
1
2
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["33.33","33.33","33.33"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Stem Cell Reviews and Reports","International Journal of Molecular Sciences","Cell Discovery"],"ids":[11731,14627,22751],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,33.33,33.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Multidisciplinary Digital Publishing Institute (MDPI)"],"ids":[8,202],"codes":[0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[2,1],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":[66.67,33.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Averina O. A. et al. Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice // International Journal of Molecular Sciences. 2022. Vol. 23. No. 11. p. 6056.
GOST all authors (up to 50)
Copy
Averina O. A., Laptev I. G., Emelianova M. A., Permyakov O. A., Mariasina S., Nikiforova A. I., Manskikh V. N., Grigorieva O. O., Bolikhova A. K., Kalabin G. A., Dontsova O. A., Sergiev P. V. Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice // International Journal of Molecular Sciences. 2022. Vol. 23. No. 11. p. 6056.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms23116056
UR - https://doi.org/10.3390%2Fijms23116056
TI - Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice
T2 - International Journal of Molecular Sciences
AU - Averina, Olga A
AU - Permyakov, Oleg A
AU - Nikiforova, Alyona I
AU - Bolikhova, Anastasia K
AU - Dontsova, Olga A.
AU - Laptev, Ivan G
AU - Emelianova, Mariia A
AU - Manskikh, Vasily N
AU - Kalabin, Gennady A
AU - Grigorieva, Olga O
AU - Mariasina, Sofia
AU - Sergiev, Petr V.
PY - 2022
DA - 2022/05/27 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6056
IS - 11
VL - 23
PMID - 35682734
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex
Copy
@article{2022_Averina,
author = {Olga A Averina and Oleg A Permyakov and Alyona I Nikiforova and Anastasia K Bolikhova and Olga A. Dontsova and Ivan G Laptev and Mariia A Emelianova and Vasily N Manskikh and Gennady A Kalabin and Olga O Grigorieva and Sofia Mariasina and Petr V. Sergiev},
title = {Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fijms23116056},
number = {11},
pages = {6056},
doi = {10.3390/ijms23116056}
}
Cite this
MLA
Copy
Averina, Olga A., et al. “Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.” International Journal of Molecular Sciences, vol. 23, no. 11, May. 2022, p. 6056. https://doi.org/10.3390%2Fijms23116056.