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International Journal of Molecular Sciences, том 23, издание 11, номер публикации: 6056

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice

Averina Olga A. 1, 2
Laptev Ivan G. 2
Emelianova Mariia A. 3
Permyakov Oleg A. 1
Nikiforova Alyona I. 4
Manskikh Vasily N. 2
Grigorieva Olga O. 1
Bolikhova Anastasia K. 5
Kalabin Gennady A. 6
Dontsova Olga A. 2, 3, 7, 8
Sergiev Petr V. 1, 2, 3, 7
Тип документаJournal Article
Дата публикации2022-05-27
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Название журналаInternational Journal of Molecular Sciences
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 20216.21
ISSN16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Краткое описание
Mitochondrial translation is a unique relic of the symbiotic origin of the organelle. Alterations of its components cause a number of severe human diseases. Hereby we report a study of mice devoid of Mettl15 mitochondrial 12S rRNA methyltransferase, responsible for the formation of m4C839 residue (human numbering). Homozygous Mettl15−/− mice appeared to be viable in contrast to other mitochondrial rRNA methyltransferase knockouts reported earlier. The phenotype of Mettl15−/− mice is much milder than that of other mutants of mitochondrial translation apparatus. In agreement with the results obtained earlier for cell cultures with an inactivated Mettl15 gene, we observed accumulation of the RbfA factor, normally associated with the precursor of the 28S subunit, in the 55S mitochondrial ribosome fraction of knockout mice. A lack of Mettl15 leads to a lower blood glucose level after physical exercise relative to that of the wild-type mice. Mettl15−/− mice demonstrated suboptimal muscle performance and lower levels of Cox3 protein synthesized by mitoribosomes in the oxidative soleus muscles. Additionally, we detected decreased learning capabilities in the Mettl15−/− knockout mice in the tests with both positive and negative reinforcement. Such properties make Mettl15−/− knockout mice a suitable model for mild mitochondriopathies.
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1. Averina O. A. и др. Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice // International Journal of Molecular Sciences. 2022. Т. 23. № 11. С. 6056.
RIS |
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TY - JOUR

DO - 10.3390/ijms23116056

UR - http://dx.doi.org/10.3390/ijms23116056

TI - Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice

T2 - International Journal of Molecular Sciences

AU - Averina, Olga A.

AU - Laptev, Ivan G.

AU - Emelianova, Mariia A.

AU - Permyakov, Oleg A.

AU - Mariasina, Sofia S.

AU - Nikiforova, Alyona I.

AU - Manskikh, Vasily N.

AU - Grigorieva, Olga O.

AU - Bolikhova, Anastasia K.

AU - Kalabin, Gennady A.

AU - Dontsova, Olga A.

AU - Sergiev, Petr V.

PY - 2022

DA - 2022/05/27

PB - MDPI AG

SP - 6056

IS - 11

VL - 23

SN - 1422-0067

ER -

BibTex |
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@article{Averina_2022,

doi = {10.3390/ijms23116056},

url = {https://doi.org/10.3390%2Fijms23116056},

year = 2022,

month = {may},

publisher = {{MDPI} {AG}},

volume = {23},

number = {11},

pages = {6056},

author = {Olga A. Averina and Ivan G. Laptev and Mariia A. Emelianova and Oleg A. Permyakov and Sofia S. Mariasina and Alyona I. Nikiforova and Vasily N. Manskikh and Olga O. Grigorieva and Anastasia K. Bolikhova and Gennady A. Kalabin and Olga A. Dontsova and Petr V. Sergiev},

title = {Mitochondrial {rRNA} Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice},

journal = {International Journal of Molecular Sciences}

}

MLA
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Averina, Olga A., et al. “Mitochondrial RRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.” International Journal of Molecular Sciences, vol. 23, no. 11, May 2022, p. 6056. Crossref, https://doi.org/10.3390/ijms23116056.