Open Access
Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications
Publication type: Journal Article
Publication date: 2023-02-02
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
36769260
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Piperidines are among the most important synthetic fragments for designing drugs and play a significant role in the pharmaceutical industry. Their derivatives are present in more than twenty classes of pharmaceuticals, as well as alkaloids. The current review summarizes recent scientific literature on intra- and intermolecular reactions leading to the formation of various piperidine derivatives: substituted piperidines, spiropiperidines, condensed piperidines, and piperidinones. Moreover, the pharmaceutical applications of synthetic and natural piperidines were covered, as well as the latest scientific advances in the discovery and biological evaluation of potential drugs containing piperidine moiety. This review is designed to help both novice researchers taking their first steps in this field and experienced scientists looking for suitable substrates for the synthesis of biologically active piperidines.
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122
Total citations:
122
Citations from 2025:
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(52.46%)
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GOST
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Frolov N. A., Vereshchagin A. N. Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications // International Journal of Molecular Sciences. 2023. Vol. 24. No. 3. p. 2937.
GOST all authors (up to 50)
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Frolov N. A., Vereshchagin A. N. Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications // International Journal of Molecular Sciences. 2023. Vol. 24. No. 3. p. 2937.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms24032937
UR - https://doi.org/10.3390/ijms24032937
TI - Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications
T2 - International Journal of Molecular Sciences
AU - Frolov, Nikita A.
AU - Vereshchagin, Anatoly N.
PY - 2023
DA - 2023/02/02
PB - MDPI
SP - 2937
IS - 3
VL - 24
PMID - 36769260
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Frolov,
author = {Nikita A. Frolov and Anatoly N. Vereshchagin},
title = {Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {MDPI},
month = {feb},
url = {https://doi.org/10.3390/ijms24032937},
number = {3},
pages = {2937},
doi = {10.3390/ijms24032937}
}
Cite this
MLA
Copy
Frolov, Nikita A., and Anatoly N. Vereshchagin. “Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications.” International Journal of Molecular Sciences, vol. 24, no. 3, Feb. 2023, p. 2937. https://doi.org/10.3390/ijms24032937.