Open Access
International Journal of Molecular Sciences, volume 24, issue 7, pages 6558
Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation
Sitnikov Dmitry S.
1
,
Revkova Veronika
2, 3
,
Ilina Inna V.
1
,
Shatalova Rimma
4
,
Komarov Pavel
1
,
Struleva Evgenia
1
,
Konoplyannikov Mikhail
2, 5
,
Kalsin Vladimir
2, 3
,
Баклаушев В. П.
2, 3, 6
2
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, 119435 Moscow, Russia
|
Publication type: Journal Article
Publication date: 2023-03-31
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
THz radiation induces a variety of processes in cells and has attracted the attention of researchers in recent decades. Here, data on the effects of high-intensity terahertz (THz) radiation on human directly reprogrammed neural progenitor cells (drNPCs) and on neuroblastoma cells (SK-N-BE (2)) were obtained for the first time. The results demonstrated that the exposure of non-tumor and tumor cells to broadband (0.1–3 THz) THz pulses with the intensity of 21 GW/cm2 and the electric field strength of 2.8 MV/cm for 30 min induced neither a noticeable genotoxic effect nor a statistically significant change in the proliferative activity and cell differentiation. It was also shown that the combined effect of THz radiation and salinomycin, a promising antitumor agent, on neuroblastoma cells did not enhance the genotoxic effect of this antibiotic. However, further studies involving chemotherapy drugs and other exposure parameters are warranted to introduce this new concept into anti-tumor clinical practice and to enhance the efficacy of the existing approaches.
Citations by journals
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1
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Cancers
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Cancers
1 publication, 50%
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Radiophysics and Quantum Electronics
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Radiophysics and Quantum Electronics
1 publication, 50%
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1
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Citations by publishers
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1
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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Springer Nature
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Springer Nature
1 publication, 50%
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1
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- Statistics recalculated weekly.
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GOST
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Sitnikov D. S. et al. Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation // International Journal of Molecular Sciences. 2023. Vol. 24. No. 7. p. 6558.
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Sitnikov D. S., Revkova V., Ilina I. V., Shatalova R., Komarov P., Struleva E., Konoplyannikov M., Kalsin V., Баклаушев В. П. Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation // International Journal of Molecular Sciences. 2023. Vol. 24. No. 7. p. 6558.
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RIS
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TY - JOUR
DO - 10.3390/ijms24076558
UR - https://doi.org/10.3390%2Fijms24076558
TI - Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation
T2 - International Journal of Molecular Sciences
AU - Sitnikov, Dmitry S.
AU - Revkova, Veronika
AU - Ilina, Inna V.
AU - Shatalova, Rimma
AU - Komarov, Pavel
AU - Struleva, Evgenia
AU - Konoplyannikov, Mikhail
AU - Kalsin, Vladimir
AU - Баклаушев, В. П.
PY - 2023
DA - 2023/03/31 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6558
IS - 7
VL - 24
SN - 1661-6596
SN - 1422-0067
ER -
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BibTex
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@article{2023_Sitnikov,
author = {Dmitry S. Sitnikov and Veronika Revkova and Inna V. Ilina and Rimma Shatalova and Pavel Komarov and Evgenia Struleva and Mikhail Konoplyannikov and Vladimir Kalsin and В. П. Баклаушев},
title = {Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fijms24076558},
number = {7},
pages = {6558},
doi = {10.3390/ijms24076558}
}
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MLA
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Sitnikov, Dmitry S., et al. “Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation.” International Journal of Molecular Sciences, vol. 24, no. 7, Mar. 2023, p. 6558. https://doi.org/10.3390%2Fijms24076558.
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