Open Access

Molecules

, volume 24 , issue 19 , pages 3433

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Anastasia Khandazhinskaya ¹

Elena Matyugina ¹

Pavel N. Solyev ¹

Maggie Wilkinson ²

Karen Buckheit ²

Robert Buckheit ²

Larisa Chernousova ³

Tatiana Smirnova ³

Sofya Andreevskaya ³

Khalid Alzahrani ^{4, 5}

Manal Natto ⁴

Sergey Kochetkov ¹

Harry P. De Koning ⁴

Katherine L. Seley-Radtke ⁶

Hide authors affiliations Show authors affiliations: 6 affiliations

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia |

ImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA |

Central Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia |

⁴

Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK |

⁵

Department of Clinical Laboratory, College of Applied Medical Sciences, Taif University, Taif 21974, Saudi Arabia |

⁶

Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA |

Publication type: Journal Article

Publication date: 2019-09-21

MDPI

Molecules

scimago Q1

wos Q2

SJR: 0.865

CiteScore: 8.6

Impact factor: 4.6

ISSN: 14203049

DOI: 10.3390/molecules24193433

Copy DOI

PubMed ID: 31546633

Organic Chemistry

Drug Discovery

Physical and Theoretical Chemistry

Pharmaceutical Science

Molecular Medicine

Analytical Chemistry

Chemistry (miscellaneous)

Abstract

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

Found

Top-30

Journals

	1 2
Molecules	Molecules, 2, 15.38% Molecules 2 publications, 15.38%
Acta Naturae	Acta Naturae, 1, 7.69% Acta Naturae 1 publication, 7.69%
Letters in Organic Chemistry	Letters in Organic Chemistry, 1, 7.69% Letters in Organic Chemistry 1 publication, 7.69%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 7.69% Frontiers in Chemistry 1 publication, 7.69%
Computational and Theoretical Chemistry	Computational and Theoretical Chemistry, 1, 7.69% Computational and Theoretical Chemistry 1 publication, 7.69%
Medicinal Research Reviews	Medicinal Research Reviews, 1, 7.69% Medicinal Research Reviews 1 publication, 7.69%
ACS Infectious Diseases	ACS Infectious Diseases, 1, 7.69% ACS Infectious Diseases 1 publication, 7.69%
Topics in Medicinal Chemistry	Topics in Medicinal Chemistry, 1, 7.69% Topics in Medicinal Chemistry 1 publication, 7.69%
Proceedings of the National Academy of Sciences of Belarus Biological Series	Proceedings of the National Academy of Sciences of Belarus Biological Series, 1, 7.69% Proceedings of the National Academy of Sciences of Belarus Biological Series 1 publication, 7.69%
Open Chemistry	Open Chemistry, 1, 7.69% Open Chemistry 1 publication, 7.69%
Nucleosides, Nucleotides and Nucleic Acids	Nucleosides, Nucleotides and Nucleic Acids, 1, 7.69% Nucleosides, Nucleotides and Nucleic Acids 1 publication, 7.69%
Journal of Organic Chemistry	Journal of Organic Chemistry, 1, 7.69% Journal of Organic Chemistry 1 publication, 7.69%
	1 2

Publishers

	1 2
MDPI	MDPI, 2, 15.38% MDPI 2 publications, 15.38%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 15.38% American Chemical Society (ACS) 2 publications, 15.38%
Acta Naturae Ltd	Acta Naturae Ltd, 1, 7.69% Acta Naturae Ltd 1 publication, 7.69%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 7.69% Bentham Science Publishers Ltd. 1 publication, 7.69%
Frontiers Media S.A.	Frontiers Media S.A., 1, 7.69% Frontiers Media S.A. 1 publication, 7.69%
Elsevier	Elsevier, 1, 7.69% Elsevier 1 publication, 7.69%
Wiley	Wiley, 1, 7.69% Wiley 1 publication, 7.69%
Springer Nature	Springer Nature, 1, 7.69% Springer Nature 1 publication, 7.69%
Publishing House Belorusskaya Nauka	Publishing House Belorusskaya Nauka, 1, 7.69% Publishing House Belorusskaya Nauka 1 publication, 7.69%
Walter de Gruyter	Walter de Gruyter, 1, 7.69% Walter de Gruyter 1 publication, 7.69%
Taylor & Francis	Taylor & Francis, 1, 7.69% Taylor & Francis 1 publication, 7.69%
	1 2

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Khandazhinskaya A. et al. Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents // Molecules. 2019. Vol. 24. No. 19. p. 3433.

GOST all authors (up to 50) Copy

Khandazhinskaya A., Matyugina E., Solyev P. N., Wilkinson M., Buckheit K., Buckheit R., Chernousova L., Smirnova T., Andreevskaya S., Alzahrani K., Natto M., Kochetkov S., De Koning H. P., Seley-Radtke K. L. Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents // Molecules. 2019. Vol. 24. No. 19. p. 3433.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3390/molecules24193433

UR - https://doi.org/10.3390/molecules24193433

TI - Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

T2 - Molecules

AU - Khandazhinskaya, Anastasia

AU - Matyugina, Elena

AU - Solyev, Pavel N.

AU - Wilkinson, Maggie

AU - Buckheit, Karen

AU - Buckheit, Robert

AU - Chernousova, Larisa

AU - Smirnova, Tatiana

AU - Andreevskaya, Sofya

AU - Alzahrani, Khalid

AU - Natto, Manal

AU - Kochetkov, Sergey

AU - De Koning, Harry P.

AU - Seley-Radtke, Katherine L.

PY - 2019

DA - 2019/09/21

PB - MDPI

SP - 3433

IS - 19

VL - 24

PMID - 31546633

SN - 1420-3049

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Khandazhinskaya,

author = {Anastasia Khandazhinskaya and Elena Matyugina and Pavel N. Solyev and Maggie Wilkinson and Karen Buckheit and Robert Buckheit and Larisa Chernousova and Tatiana Smirnova and Sofya Andreevskaya and Khalid Alzahrani and Manal Natto and Sergey Kochetkov and Harry P. De Koning and Katherine L. Seley-Radtke},

title = {Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents},

journal = {Molecules},

year = {2019},

volume = {24},

publisher = {MDPI},

month = {sep},

url = {https://doi.org/10.3390/molecules24193433},

number = {19},

pages = {3433},

doi = {10.3390/molecules24193433}

}

MLA

Cite this

MLA Copy

Khandazhinskaya, Anastasia, et al. “Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.” Molecules, vol. 24, no. 19, Sep. 2019, p. 3433. https://doi.org/10.3390/molecules24193433.

Publisher

MDPI

Journal

Molecules

scimago Q1

wos Q2

SJR

0.865

CiteScore

8.6

Impact factor

4.6

ISSN

14203049 (Print, Electronic)

Labs

Laboratory of chemical regulation of biocatalysis

Profiles