Open Access
Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen
Тип публикации: Journal Article
Дата публикации: 2020-12-08
PubMed ID:
33302417
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Краткое описание
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PSMA-targeting Glu-Urea-Lys (EuK) fragment as a vector moiety and tripeptide linker with terminal amide and azide groups for subsequent addition of two different therapeutic and diagnostic agents. The optimal method for this molecular platform synthesis includes (a) solid-phase assembly of the polypeptide linker, (b) coupling of this linker with the vector fragment, (c) attachment of 3-aminopropylazide, and (d) amide and carboxylic groups deprotection. A bimodal theranostic conjugate of the proposed platform with a cytostatic drug (docetaxel) and a fluorescent label (Sulfo-Cy5) was synthesized to demonstrate its possible sequential conjugation with different functional molecules.
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Petrov S. B. et al. Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen // Molecules. 2020. Vol. 25. No. 24. p. 5784.
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Petrov S. B., Machulkin A. E., Uspenskaya A. A., Zyk N. Y., Nimenko E. A., Garanina A. S., Petrov R. A., Polshakov V. I., Grishin Y. K., Roznyatovsky V. A., Zyk N. V., Majouga A. G., Beloglazkina E. K. Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen // Molecules. 2020. Vol. 25. No. 24. p. 5784.
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TY - JOUR
DO - 10.3390/molecules25245784
UR - https://www.mdpi.com/1420-3049/25/24/5784
TI - Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen
T2 - Molecules
AU - Petrov, Stanislav B.
AU - Machulkin, Aleksei E.
AU - Uspenskaya, Anastasia A
AU - Zyk, Nikolay Y
AU - Nimenko, Ekaterina A.
AU - Garanina, A. S.
AU - Petrov, Rostislav A
AU - Polshakov, Vladimir I.
AU - Grishin, Yuri K.
AU - Roznyatovsky, Vitaly A
AU - Zyk, Nikolay V.
AU - Majouga, Alexander G.
AU - Beloglazkina, Elena K.
PY - 2020
DA - 2020/12/08
PB - MDPI
SP - 5784
IS - 24
VL - 25
PMID - 33302417
SN - 1420-3049
ER -
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@article{2020_Petrov,
author = {Stanislav B. Petrov and Aleksei E. Machulkin and Anastasia A Uspenskaya and Nikolay Y Zyk and Ekaterina A. Nimenko and A. S. Garanina and Rostislav A Petrov and Vladimir I. Polshakov and Yuri K. Grishin and Vitaly A Roznyatovsky and Nikolay V. Zyk and Alexander G. Majouga and Elena K. Beloglazkina},
title = {Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {MDPI},
month = {dec},
url = {https://www.mdpi.com/1420-3049/25/24/5784},
number = {24},
pages = {5784},
doi = {10.3390/molecules25245784}
}
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MLA
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Petrov, Stanislav B., et al. “Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen.” Molecules, vol. 25, no. 24, Dec. 2020, p. 5784. https://www.mdpi.com/1420-3049/25/24/5784.