Open Access
Molecules, volume 25, issue 24, pages 5784
Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen
Machulkin Aleksei E.
1, 2
,
Zyk Nikolay Y
1
,
Nimenko Ekaterina A.
1
,
Garanina A. S.
1, 2
,
Petrov Rostislav A
1
,
Grishin Yuri K.
1
,
Zyk Nikolay V.
1
,
Majouga Alexander G.
1, 2, 4
,
Publication type: Journal Article
Publication date: 2020-12-08
PubMed ID:
33302417
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PSMA-targeting Glu-Urea-Lys (EuK) fragment as a vector moiety and tripeptide linker with terminal amide and azide groups for subsequent addition of two different therapeutic and diagnostic agents. The optimal method for this molecular platform synthesis includes (a) solid-phase assembly of the polypeptide linker, (b) coupling of this linker with the vector fragment, (c) attachment of 3-aminopropylazide, and (d) amide and carboxylic groups deprotection. A bimodal theranostic conjugate of the proposed platform with a cytostatic drug (docetaxel) and a fluorescent label (Sulfo-Cy5) was synthesized to demonstrate its possible sequential conjugation with different functional molecules.
Citations by journals
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1
2
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
2 publications, 15.38%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 15.38%
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Journal of Molecular Structure
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Journal of Molecular Structure
1 publication, 7.69%
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Bioorganic and Medicinal Chemistry Letters
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Bioorganic and Medicinal Chemistry Letters
1 publication, 7.69%
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Medicinal Chemistry Research
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Medicinal Chemistry Research
1 publication, 7.69%
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Current Medicinal Chemistry
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Current Medicinal Chemistry
1 publication, 7.69%
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Molecules
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Molecules
1 publication, 7.69%
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ACS Applied Nano Materials
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ACS Applied Nano Materials
1 publication, 7.69%
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Mendeleev Communications
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Mendeleev Communications
1 publication, 7.69%
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Biochemistry (Moscow)
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Biochemistry (Moscow)
1 publication, 7.69%
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1
2
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Citations by publishers
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1
2
3
4
5
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Elsevier
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Elsevier
5 publications, 38.46%
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Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 23.08%
|
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Springer Nature
|
Springer Nature
1 publication, 7.69%
|
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Bentham Science
|
Bentham Science
1 publication, 7.69%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 7.69%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 7.69%
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1
2
3
4
5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Petrov S. B. et al. Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen // Molecules. 2020. Vol. 25. No. 24. p. 5784.
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Petrov S. B., Machulkin A. E., Uspenskaya A. A., Zyk N. Y., Nimenko E. A., Garanina A. S., Petrov R. A., Polshakov V. I., Grishin Y. K., Roznyatovsky V. A., Zyk N. V., Majouga A. G., Beloglazkina E. K. Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen // Molecules. 2020. Vol. 25. No. 24. p. 5784.
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TY - JOUR
DO - 10.3390/molecules25245784
UR - https://doi.org/10.3390%2Fmolecules25245784
TI - Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen
T2 - Molecules
AU - Uspenskaya, Anastasia A
AU - Zyk, Nikolay Y
AU - Nimenko, Ekaterina A.
AU - Grishin, Yuri K.
AU - Zyk, Nikolay V.
AU - Majouga, Alexander G.
AU - Petrov, Stanislav B.
AU - Machulkin, Aleksei E.
AU - Garanina, A. S.
AU - Petrov, Rostislav A
AU - Polshakov, Vladimir I.
AU - Roznyatovsky, Vitaly A
AU - Beloglazkina, Elena K.
PY - 2020
DA - 2020/12/08 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 5784
IS - 24
VL - 25
PMID - 33302417
SN - 1420-3049
ER -
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@article{2020_Petrov,
author = {Anastasia A Uspenskaya and Nikolay Y Zyk and Ekaterina A. Nimenko and Yuri K. Grishin and Nikolay V. Zyk and Alexander G. Majouga and Stanislav B. Petrov and Aleksei E. Machulkin and A. S. Garanina and Rostislav A Petrov and Vladimir I. Polshakov and Vitaly A Roznyatovsky and Elena K. Beloglazkina},
title = {Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2Fmolecules25245784},
number = {24},
pages = {5784},
doi = {10.3390/molecules25245784}
}
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Petrov, Stanislav B., et al. āPolypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen.ā Molecules, vol. 25, no. 24, Dec. 2020, p. 5784. https://doi.org/10.3390%2Fmolecules25245784.