Open Access
Molecules, volume 26, issue 21, pages 6579
Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
Publication type: Journal Article
Publication date: 2021-10-30
PubMed ID:
34770986
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Biogenic polyamines (PAs) are involved in the growth and development of normal cells, and their intracellular concentration is stable. The concentration of PAs in cancer cells is significantly increased to promote and sustain their rapid proliferation. Over the years, synthetic PAs, which differ in their structure, have demonstrated high antitumor activity and are involved in clinical trials. The chemical synthesis of PAs and their conjugates require the correct choice of synthetic pathways—methods for constructing conjugates and the orthogonal protection of amino groups. The most common methods of synthesis of PA conjugates are acylation of regioselectively protected PAs or their alkylation under the conditions of the Fukuyama reaction. One of the most promising methods of PA synthesis is the use of a multicomponent Ugi reaction, which allows various PAs to be obtained in high yields. In this review, we describe and analyze various approaches that are used in the synthesis of polyamines and their conjugates.
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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4 publications, 57.14%
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1 publication, 14.29%
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Springer Nature
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Taylor & Francis
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1 publication, 14.29%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nichugovskiy A. I., Tron G. C., Maslov M. Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications // Molecules. 2021. Vol. 26. No. 21. p. 6579.
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Nichugovskiy A. I., Tron G. C., Maslov M. Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications // Molecules. 2021. Vol. 26. No. 21. p. 6579.
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TY - JOUR
DO - 10.3390/molecules26216579
UR - https://doi.org/10.3390%2Fmolecules26216579
TI - Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
T2 - Molecules
AU - Nichugovskiy, A I
AU - Tron, Gian Cesare
AU - Maslov, Michael
PY - 2021
DA - 2021/10/30 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6579
IS - 21
VL - 26
PMID - 34770986
SN - 1420-3049
ER -
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@article{2021_Nichugovskiy,
author = {A I Nichugovskiy and Gian Cesare Tron and Michael Maslov},
title = {Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2Fmolecules26216579},
number = {21},
pages = {6579},
doi = {10.3390/molecules26216579}
}
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Nichugovskiy, A. I., et al. “Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications.” Molecules, vol. 26, no. 21, Oct. 2021, p. 6579. https://doi.org/10.3390%2Fmolecules26216579.
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