Open Access
Molecules, volume 26, issue 22, pages 6899
Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
Georgiana Cicalău
1, 2
,
Petru Babes
1
,
Horia Calniceanu
3, 4
,
Adelina Popa
5, 6
,
Gabriela Ciavoi
2
,
Gilda Iova
2
,
Mariana Ganea
7
,
Ioana Scrobota
2
1
Doctoral School of Biomedical Science, University of Oradea, 1st University Street, 410087 Oradea, Romania
|
2
Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, Romania
|
3
Department of Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
|
4
Periodontal and Periimplant Diseases Research Center “Prof. Dr. Anton Sculean”, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
|
5
Department of Orthodontics, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
|
6
Orthodontic Research Center (ORTHO-CENTER), Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
|
7
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, Romania
|
Publication type: Journal Article
Publication date: 2021-11-16
PubMed ID:
34833990
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.
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GOST
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Cicalău G. et al. Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus // Molecules. 2021. Vol. 26. No. 22. p. 6899.
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Cicalău G., Babes P., Calniceanu H., Popa A., Ciavoi G., Iova G., Ganea M., Scrobota I. Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus // Molecules. 2021. Vol. 26. No. 22. p. 6899.
Cite this
RIS
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TY - JOUR
DO - 10.3390/molecules26226899
UR - https://doi.org/10.3390/molecules26226899
TI - Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
T2 - Molecules
AU - Cicalău, Georgiana
AU - Babes, Petru
AU - Calniceanu, Horia
AU - Popa, Adelina
AU - Ciavoi, Gabriela
AU - Iova, Gilda
AU - Ganea, Mariana
AU - Scrobota, Ioana
PY - 2021
DA - 2021/11/16
PB - MDPI
SP - 6899
IS - 22
VL - 26
PMID - 34833990
SN - 1420-3049
ER -
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BibTex (up to 50 authors)
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@article{2021_Cicalău,
author = {Georgiana Cicalău and Petru Babes and Horia Calniceanu and Adelina Popa and Gabriela Ciavoi and Gilda Iova and Mariana Ganea and Ioana Scrobota},
title = {Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {nov},
url = {https://doi.org/10.3390/molecules26226899},
number = {22},
pages = {6899},
doi = {10.3390/molecules26226899}
}
Cite this
MLA
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Cicalău, Georgiana, et al. “Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus.” Molecules, vol. 26, no. 22, Nov. 2021, p. 6899. https://doi.org/10.3390/molecules26226899.