Open Access
Molecules, volume 27, issue 10, pages 3115
Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make
Egorova B. V.
1
,
Zamurueva Lyubov S
1
,
Pashanova Anna V
2, 3
,
Mitrofanov Artem
1
,
Priselkova Anna B
4
,
Fedorov Yuri V
2
,
Fedorova Olga A
2
,
1
Publication type: Journal Article
Publication date: 2022-05-12
PubMed ID:
35630592
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
A synthetic procedure for the synthesis of azacrown ethers with a combination of pendant arms has been developed and the synthesized ligand, characterized by various techniques, was studied. The prepared benzoazacrown ether with hybrid pendant arms and its complexes with copper and lead cations were studied in terms of biomedical applications. Similarly to a fully acetate analog, the new one binds both cations with close stability constants, despite the decrease in both constants. The calculated geometry of the complexes correlate with the data from X-ray absorption and NMR spectroscopy. Coordination of both cations differs due to the difference between the ionic radii. However, these chelation modes provide effective shielding of cations in both cases, that was shown by the stability of their complexes in the biologically relevant media towards transchelation and transmetallation.
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Mendeleev Communications
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Mendeleev Communications
1 publication, 100%
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Elsevier
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Elsevier
1 publication, 100%
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Egorova B. V. et al. Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make // Molecules. 2022. Vol. 27. No. 10. p. 3115.
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Egorova B. V., Zamurueva L. S., Zubenko A., Pashanova A. V., Mitrofanov A., Priselkova A. B., Fedorov Y. V., Trigub A. L., Fedorova O. A., Kalmykov S. N. Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make // Molecules. 2022. Vol. 27. No. 10. p. 3115.
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TY - JOUR
DO - 10.3390/molecules27103115
UR - https://doi.org/10.3390%2Fmolecules27103115
TI - Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make
T2 - Molecules
AU - Zamurueva, Lyubov S
AU - Fedorov, Yuri V
AU - Trigub, Alexander L
AU - Fedorova, Olga A
AU - Kalmykov, Stepan N.
AU - Pashanova, Anna V
AU - Priselkova, Anna B
AU - Egorova, B. V.
AU - Zubenko, Anastasia
AU - Mitrofanov, Artem
PY - 2022
DA - 2022/05/12 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 3115
IS - 10
VL - 27
PMID - 35630592
SN - 1420-3049
ER -
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@article{2022_Egorova,
author = {Lyubov S Zamurueva and Yuri V Fedorov and Alexander L Trigub and Olga A Fedorova and Stepan N. Kalmykov and Anna V Pashanova and Anna B Priselkova and B. V. Egorova and Anastasia Zubenko and Artem Mitrofanov},
title = {Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fmolecules27103115},
number = {10},
pages = {3115},
doi = {10.3390/molecules27103115}
}
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Egorova, B. V., et al. “Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make.” Molecules, vol. 27, no. 10, May. 2022, p. 3115. https://doi.org/10.3390%2Fmolecules27103115.