Open Access
Open access
MDPI
Molecules
,  volume 27 ,  issue 19 ,  pages 6447

Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels

Publication type: Journal Article
Publication date: 2022-09-30
MDPI
scimago Q1
wos Q2
SJR: 0.865
CiteScore: 8.6
Impact factor: 4.6
ISSN: 14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract

Abietic acid, a naturally occurring fir resin compound, that exhibits anti-inflammatory and wound-healing properties, was formulated into biocompatible emulgels based on stable microemulsions with the addition of a carbamate-containing surfactant and Carbopol® 940 gel. Various microemulsion and emulgel formulations were tested for antioxidant and wound-healing properties. The chemiluminescence method has shown that all compositions containing abietic acid have a high antioxidant activity. Using Strat-M® skin-modelling membrane, it was found out that emulgels significantly prolong the release of abietic acid. On Wistar rats, it was shown that microemulsions and emulgels containing 0.5% wt. of abietic acid promote the rapid healing of an incised wound and twofold tissue reinforcement compared to the untreated group, as documented by tensiometric wound suture-rupture assay. The high healing-efficiency is associated with a combination of antibacterial activity of the formulation components and the anti-inflammatory action of abietic acid.

Found 
Found 
4 citations
Zakharova Lucia
DSc in Chemistry, professor
394 publications,  6 176 citations
h-index: 36
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
3 citations
Gaynanova Gulnara
PhD in Chemistry
74 publications,  1 073 citations,  1 review
h-index: 18
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
Research interests
Colloidal chemistry
Drug delivery systems
Physical Chemistry
Supramolecular chemistry
Surfactants
2 citations
Vasilyeva Leysan
PhD in Chemistry
29 publications,  492 citations
h-index: 14
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
Research interests
Colloidal chemistry
Drug delivery systems
Physical Chemistry
Surfactants
2 citations
Vasilieva Elmira
PhD in Chemistry
48 publications,  706 citations,  5 reviews
h-index: 16
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
Research interests
Drug delivery systems
Polymer science
Supramolecular chemistry
Surfactants
2 citations
Kuznetsova Darya
PhD in Chemistry
60 publications,  1 089 citations,  12 reviews
h-index: 21
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
1 citation
Kuznetsov Denis
PhD in Chemistry
46 publications,  587 citations
h-index: 14
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
1 citation
Boldeiu Adina
🤝
79 publications,  511 citations,  3 reviews
h-index: 12
National Institute for Research and Development in Microtechnologies
National Institute for Research and Development in Microtechnologies

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GOST Copy
Mirgorodskaya A. et al. Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels // Molecules. 2022. Vol. 27. No. 19. p. 6447.
GOST all authors (up to 50) Copy
Mirgorodskaya A., Kushnazarova R., Pavlov R., Valeeva F., Lenina O., Bushmeleva K., Kuryashov D., Vyshtakalyuk A., Gaynanova G., Petrov K., Zakharova L. Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels // Molecules. 2022. Vol. 27. No. 19. p. 6447.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/molecules27196447
UR - https://doi.org/10.3390/molecules27196447
TI - Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels
T2 - Molecules
AU - Mirgorodskaya, Alla
AU - Kushnazarova, Rushana
AU - Pavlov, Rais
AU - Valeeva, Farida
AU - Lenina, Oksana
AU - Bushmeleva, Kseniya
AU - Kuryashov, Dmitry
AU - Vyshtakalyuk, Alexandra
AU - Gaynanova, Gulnara
AU - Petrov, Konstantin
AU - Zakharova, Lucia
PY - 2022
DA - 2022/09/30
PB - MDPI
SP - 6447
IS - 19
VL - 27
PMID - 36234983
SN - 1420-3049
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Mirgorodskaya,
author = {Alla Mirgorodskaya and Rushana Kushnazarova and Rais Pavlov and Farida Valeeva and Oksana Lenina and Kseniya Bushmeleva and Dmitry Kuryashov and Alexandra Vyshtakalyuk and Gulnara Gaynanova and Konstantin Petrov and Lucia Zakharova},
title = {Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {MDPI},
month = {sep},
url = {https://doi.org/10.3390/molecules27196447},
number = {19},
pages = {6447},
doi = {10.3390/molecules27196447}
}
MLA
Cite this
MLA Copy
Mirgorodskaya, Alla, et al. “Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels.” Molecules, vol. 27, no. 19, Sep. 2022, p. 6447. https://doi.org/10.3390/molecules27196447.