Open Access
The Study of Hypoglycemic Activity of 7-Terpenylcoumarins
Sergey Kuranov
1
,
Mariya Marenina
1
,
Dmitriy Ivankin
1
,
Mikhail Blokhin
1
,
Sergey Alkisovich Borisov
1
,
Tatyana Khomenko
1
,
Olga A. Luzina
1
,
Mikhail Vladimirovich Khvostov
1
,
Tatyana Tolstikova
1
,
Nariman Salakhutdinov
1
Publication type: Journal Article
Publication date: 2022-12-07
PubMed ID:
36557798
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Natural and synthetic coumarins are often considered privileged scaffolds for obtaining pharmacological agents with hypoglycemic activity. Chemical modification of coumarins often leads to antidiabetic agents with greater efficacy. In the present work, twenty monoterpene-substituted 7-hydroxycoumarins were synthesized. A new approach using the Mitsunobu reaction was shown to be effective for the synthesis of target compounds. All of the synthesized compounds were evaluated in an oral glucose tolerance test, and two of them containing geranyl and (-)-myrtenyl substituents showed in vivo hypoglycemic action. A possible mechanism of action of these compounds may include inhibition of DPP IV, which was proved in an in vitro test.
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Total citations:
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Citations from 2024:
2
(66.67%)
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GOST
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Kuranov S. et al. The Study of Hypoglycemic Activity of 7-Terpenylcoumarins // Molecules. 2022. Vol. 27. No. 24. p. 8663.
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Kuranov S., Marenina M., Ivankin D., Blokhin M., Borisov S. A., Khomenko T., Luzina O. A., Khvostov M. V., Volcho K. P., Tolstikova T., Salakhutdinov N. The Study of Hypoglycemic Activity of 7-Terpenylcoumarins // Molecules. 2022. Vol. 27. No. 24. p. 8663.
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RIS
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TY - JOUR
DO - 10.3390/molecules27248663
UR - https://doi.org/10.3390/molecules27248663
TI - The Study of Hypoglycemic Activity of 7-Terpenylcoumarins
T2 - Molecules
AU - Kuranov, Sergey
AU - Marenina, Mariya
AU - Ivankin, Dmitriy
AU - Blokhin, Mikhail
AU - Borisov, Sergey Alkisovich
AU - Khomenko, Tatyana
AU - Luzina, Olga A.
AU - Khvostov, Mikhail Vladimirovich
AU - Volcho, Konstantin P.
AU - Tolstikova, Tatyana
AU - Salakhutdinov, Nariman
PY - 2022
DA - 2022/12/07
PB - MDPI
SP - 8663
IS - 24
VL - 27
PMID - 36557798
SN - 1420-3049
ER -
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BibTex (up to 50 authors)
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@article{2022_Kuranov,
author = {Sergey Kuranov and Mariya Marenina and Dmitriy Ivankin and Mikhail Blokhin and Sergey Alkisovich Borisov and Tatyana Khomenko and Olga A. Luzina and Mikhail Vladimirovich Khvostov and Konstantin P. Volcho and Tatyana Tolstikova and Nariman Salakhutdinov},
title = {The Study of Hypoglycemic Activity of 7-Terpenylcoumarins},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {MDPI},
month = {dec},
url = {https://doi.org/10.3390/molecules27248663},
number = {24},
pages = {8663},
doi = {10.3390/molecules27248663}
}
Cite this
MLA
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Kuranov, Sergey, et al. “The Study of Hypoglycemic Activity of 7-Terpenylcoumarins.” Molecules, vol. 27, no. 24, Dec. 2022, p. 8663. https://doi.org/10.3390/molecules27248663.