Open Access
Nanomaterials, volume 9, issue 12, pages 1658
Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study
Antipina Liubov Yu
1, 2
,
Kovalskii Andrey M
1
,
Polčák J.
3, 4
,
Manakhov Anton
1
,
Sorokin Pavel B.
1
,
Shtansky Dmitry V
1
1
3
CEITEC-Central European Institute of Technology, Brno University of Technology, Technická 3058/10, 61600 Brno, Czech Republic
|
4
Institute of Physical Engineering, Brno University of Technology, Technicka 2896/2, 61669 Brno, Czech Republic
|
Publication type: Journal Article
Publication date: 2019-11-21
PubMed ID:
31766559
General Chemical Engineering
General Materials Science
Abstract
A new low-pressure plasma-based approach to activate the surface of BN nanoparticles (BNNPs) in order to facilitate the attachment of folate acid (FA) molecules for cancer-specific therapy is described. Plasma treatment of BNNPs (BNNPsPT) was performed in a radiofrequency plasma reactor using ethylene and carbon dioxide monomers. The carboxyl groups deposited on the surface of BNNPsPT were activated by N,N’-dicyclohexylcarbodiimide (DCC) and participated in the condensation reaction with ethylene diamine (EDA) to form a thin amino-containing layer (EDA-BNNPPT). Then, the DCC-activated FA was covalently bonded with BNNPsPT by a chemical reaction between amino groups of EDA-BNNPsPT and carboxyl groups of FA. Density functional theory calculations showed that the pre-activation of FA by DCC is required for grafting of the FA to the EDA-BNNPsPT. It was also demonstrated that after FA immobilization, the electronic characteristics of the pteridine ring remain unchanged, indicating that the targeting properties of the FA/EDA-BNNPsPT nanohybrids are preserved.
Citations by journals
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1
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Colloids and Surfaces B: Biointerfaces
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Colloids and Surfaces B: Biointerfaces
1 publication, 16.67%
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Advanced Science
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Advanced Science
1 publication, 16.67%
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Nanotechnologies in Russia
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Nanotechnologies in Russia
1 publication, 16.67%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 16.67%
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Materials Science and Engineering B: Solid-State Materials for Advanced Technology
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Materials Science and Engineering B: Solid-State Materials for Advanced Technology
1 publication, 16.67%
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1
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Citations by publishers
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1
2
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Elsevier
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Elsevier
2 publications, 33.33%
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Wiley
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Wiley
1 publication, 16.67%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 16.67%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Permyakova E. S. et al. Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study // Nanomaterials. 2019. Vol. 9. No. 12. p. 1658.
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Permyakova E. S., Antipina L. Yu., Kiryukhantsev-Korneev P., Kovalskii A. M., Polčák J., Manakhov A., Kotyakova K. Yu., Sorokin P. B., Shtansky D. V. Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study // Nanomaterials. 2019. Vol. 9. No. 12. p. 1658.
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TY - JOUR
DO - 10.3390/nano9121658
UR - https://doi.org/10.3390%2Fnano9121658
TI - Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study
T2 - Nanomaterials
AU - Shtansky, Dmitry V
AU - Manakhov, Anton
AU - Kovalskii, Andrey M
AU - Permyakova, Elizaveta S
AU - Antipina, Liubov Yu
AU - Kiryukhantsev-Korneev, Philipp
AU - Polčák, J.
AU - Kotyakova, Kristina Yu
AU - Sorokin, Pavel B.
PY - 2019
DA - 2019/11/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1658
IS - 12
VL - 9
PMID - 31766559
SN - 2079-4991
ER -
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@article{2019_Permyakova,
author = {Dmitry V Shtansky and Anton Manakhov and Andrey M Kovalskii and Elizaveta S Permyakova and Liubov Yu Antipina and Philipp Kiryukhantsev-Korneev and J. Polčák and Kristina Yu Kotyakova and Pavel B. Sorokin},
title = {Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study},
journal = {Nanomaterials},
year = {2019},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fnano9121658},
number = {12},
pages = {1658},
doi = {10.3390/nano9121658}
}
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MLA
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Permyakova, Elizaveta S., et al. “Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study.” Nanomaterials, vol. 9, no. 12, Nov. 2019, p. 1658. https://doi.org/10.3390%2Fnano9121658.