Open Access

Pharmaceutics, volume 14, issue 1, pages 65

Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field

Burmistrov Ivan A ¹

Veselov Maxim M ²

Mikheev Alexander V ^{1, 3}

Borodina Tatiana N ¹

Bukreeva Tatiana V ^{1, 4}

Chuev Michael A ⁵

Starchikov Sergey S ¹

Lyubutin Igor S. ¹

Artemov Vladimir V. ¹

Khmelenin Dmitry N. ¹

Klyachko Natalia L. ^{2, 6}

Trushina Daria ^{1, 7}

Hide authors affiliations Show authors affiliations: 7 affiliations

Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia

FSRC "Crystallography and photonics" of NRC «Kurchatov Institute»

Shubnikov Institute of Crystallography

Department of Chemical Enzymology, Lomonosov Moscow State University, 119991 Moscow, Russia |

Faculty of Physics, Lomonosov Moscow State University, 119991 Moscow, Russia |

⁴

National Research Centre ‘‘Kurchatov Institute”, 123182 Moscow, Russia |

⁵

Valiev Institute of Physics and Technology of RAS, 117218 Moscow, Russia |

⁶

Institute “Nanotechnology and Nanomaterials”, G.R. Derzhavin Tambov State University, 392000 Tambov, Russia |

⁷

Department of Biomedical Engineering, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia |

Publication type: Journal Article

Publication date: 2021-12-28

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Pharmaceutics

Quartile SCImago

Quartile WOS

Impact factor: 5.4

ISSN: 19994923

DOI: 10.3390/pharmaceutics14010065

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PubMed ID: 35056960

Pharmaceutical Science

Abstract

Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development in recent decades. Application of a low frequency magnetic field (LFMF) as an external stimulus opens up opportunities to trigger release of the encapsulated bioactive substances with high locality and penetration ability without heating of biological tissue in vivo. Therefore, the development of novel microencapsulated drug formulations sensitive to LFMF is of paramount importance. Here, we report the result of LFMF-triggered release of the fluorescently labeled dextran from polyelectrolyte microcapsules modified with magnetic iron oxide nanoparticles. Polyelectrolyte microcapsules were obtained by a method of sequential deposition of oppositely charged poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on the surface of colloidal vaterite particles. The synthesized single domain maghemite nanoparticles integrated into the polymer multilayers serve as magneto-mechanical actuators. We report the first systematic study of the effect of magnetic field with different frequencies on the permeability of the microcapsules. The in situ measurements of the optical density curves upon the 100 mT LFMF treatment were carried out for a range of frequencies from 30 to 150 Hz. Such fields do not cause any considerable heating of the magnetic nanoparticles but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations of the adjacent materials. We observed the changes in release of the encapsulated TRITC-dextran molecules from the PAH/PSS microcapsules upon application of the 50 Hz alternating magnetic field. The obtained results open new horizons for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues.

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Citations by journals

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Pharmaceutics	Pharmaceutics, 2, 28.57% Pharmaceutics 2 publications, 28.57%
Crystal Growth and Design	Crystal Growth and Design, 1, 14.29% Crystal Growth and Design 1 publication, 14.29%
Colloid Journal	Colloid Journal, 1, 14.29% Colloid Journal 1 publication, 14.29%
Polymers	Polymers, 1, 14.29% Polymers 1 publication, 14.29%
Journal of Alloys and Compounds	Journal of Alloys and Compounds, 1, 14.29% Journal of Alloys and Compounds 1 publication, 14.29%
Separation and Purification Technology	Separation and Purification Technology, 1, 14.29% Separation and Purification Technology 1 publication, 14.29%
	1 2

Citations by publishers

	1 2 3
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 42.86% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 42.86%
Elsevier	Elsevier, 2, 28.57% Elsevier 2 publications, 28.57%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 14.29% American Chemical Society (ACS) 1 publication, 14.29%
Pleiades Publishing	Pleiades Publishing, 1, 14.29% Pleiades Publishing 1 publication, 14.29%
	1 2 3

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Burmistrov I. A. et al. Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field // Pharmaceutics. 2021. Vol. 14. No. 1. p. 65.

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Burmistrov I. A., Veselov M. M., Mikheev A. V., Borodina T. N., Bukreeva T. V., Chuev M. A., Starchikov S. S., Lyubutin I. S., Artemov V. V., Khmelenin D. N., Klyachko N. L., Trushina D. Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field // Pharmaceutics. 2021. Vol. 14. No. 1. p. 65.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/pharmaceutics14010065

UR - https://doi.org/10.3390%2Fpharmaceutics14010065

TI - Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field

T2 - Pharmaceutics

AU - Burmistrov, Ivan A

AU - Borodina, Tatiana N

AU - Starchikov, Sergey S

AU - Artemov, Vladimir V.

AU - Bukreeva, Tatiana V

AU - Lyubutin, Igor S.

AU - Khmelenin, Dmitry N.

AU - Veselov, Maxim M

AU - Mikheev, Alexander V

AU - Chuev, Michael A

AU - Klyachko, Natalia L.

AU - Trushina, Daria

PY - 2021

DA - 2021/12/28 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 65

IS - 1

VL - 14

PMID - 35056960

SN - 1999-4923

ER -

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@article{2021_Burmistrov,

author = {Ivan A Burmistrov and Tatiana N Borodina and Sergey S Starchikov and Vladimir V. Artemov and Tatiana V Bukreeva and Igor S. Lyubutin and Dmitry N. Khmelenin and Maxim M Veselov and Alexander V Mikheev and Michael A Chuev and Natalia L. Klyachko and Daria Trushina},

title = {Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field},

journal = {Pharmaceutics},

year = {2021},

volume = {14},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {dec},

url = {https://doi.org/10.3390%2Fpharmaceutics14010065},

number = {1},

pages = {65},

doi = {10.3390/pharmaceutics14010065}

}

MLA

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MLA Copy

Burmistrov, Ivan A., et al. “Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field.” Pharmaceutics, vol. 14, no. 1, Dec. 2021, p. 65. https://doi.org/10.3390%2Fpharmaceutics14010065.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Pharmaceutics

Quartile SCImago

Quartile WOS

Impact factor

5.4

ISSN

19994923 (Print)

Labs

Laboratory of Bioorganic Structures

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