Open Access

Pharmaceutics

, том 14 , издание 3 , страницы 599

Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions

Тип публикации: Journal Article

Дата публикации: 2022-03-09

MDPI

Pharmaceutics

scimago Q1

wos Q1

БС1

SJR: 1.075

CiteScore: 10

Impact factor: 5.5

ISSN: 19994923

DOI: 10.3390/pharmaceutics14030599

Скопировать DOI

PubMed ID: 35335974

Pharmaceutical Science

Краткое описание

L-asparaginases (EC 3.5.1.1) are a family of enzymes that catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. These proteins with different biochemical, physicochemical and pharmacological properties are found in many organisms, including bacteria, fungi, algae, plants and mammals. To date, asparaginases from E. coli and Dickeya dadantii (formerly known as Erwinia chrysanthemi) are widely used in hematology for the treatment of lymphoblastic leukemias. However, their medical use is limited by side effects associated with the ability of these enzymes to hydrolyze L-glutamine, as well as the development of immune reactions. To solve these issues, gene-editing methods to introduce amino-acid substitutions of the enzyme are implemented. In this review, we focused on molecular analysis of the mechanism of enzyme action and to optimize the antitumor activity.

Найдено

Для доступа к списку цитирований публикации необходимо авторизоваться.

Войти с ORCID

Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.

Войти с ORCID

Топ-30

Журналы

	1 2 3 4
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 11.11% International Journal of Molecular Sciences 4 публикации, 11.11%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 3, 8.33% International Journal of Biological Macromolecules 3 публикации, 8.33%
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2, 5.56% Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 2 публикации, 5.56%
Frontiers in Pharmacology	Frontiers in Pharmacology, 2, 5.56% Frontiers in Pharmacology 2 публикации, 5.56%
Biomeditsinskaya Khimiya	Biomeditsinskaya Khimiya, 2, 5.56% Biomeditsinskaya Khimiya 2 публикации, 5.56%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 1, 2.78% Applied Sciences (Switzerland) 1 публикация, 2.78%
Processes	Processes, 1, 2.78% Processes 1 публикация, 2.78%
Frontiers in Medicine	Frontiers in Medicine, 1, 2.78% Frontiers in Medicine 1 публикация, 2.78%
Journal of Genetic Engineering and Biotechnology	Journal of Genetic Engineering and Biotechnology, 1, 2.78% Journal of Genetic Engineering and Biotechnology 1 публикация, 2.78%
Catalysts	Catalysts, 1, 2.78% Catalysts 1 публикация, 2.78%
Journal of Agricultural and Food Chemistry	Journal of Agricultural and Food Chemistry, 1, 2.78% Journal of Agricultural and Food Chemistry 1 публикация, 2.78%
Heliyon	Heliyon, 1, 2.78% Heliyon 1 публикация, 2.78%
Biological Products Prevention Diagnosis Treatment	Biological Products Prevention Diagnosis Treatment, 1, 2.78% Biological Products Prevention Diagnosis Treatment 1 публикация, 2.78%
Applied Biochemistry and Microbiology	Applied Biochemistry and Microbiology, 1, 2.78% Applied Biochemistry and Microbiology 1 публикация, 2.78%
Applied Biochemistry and Biotechnology	Applied Biochemistry and Biotechnology, 1, 2.78% Applied Biochemistry and Biotechnology 1 публикация, 2.78%
Separation and Purification Technology	Separation and Purification Technology, 1, 2.78% Separation and Purification Technology 1 публикация, 2.78%
Immunology	Immunology, 1, 2.78% Immunology 1 публикация, 2.78%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.78% Russian Chemical Reviews 1 публикация, 2.78%
Biochemistry (Moscow)	Biochemistry (Moscow), 1, 2.78% Biochemistry (Moscow) 1 публикация, 2.78%
Biocatalysis and Biotransformation	Biocatalysis and Biotransformation, 1, 2.78% Biocatalysis and Biotransformation 1 публикация, 2.78%
Biochemistry	Biochemistry, 1, 2.78% Biochemistry 1 публикация, 2.78%
ACS Catalysis	ACS Catalysis, 1, 2.78% ACS Catalysis 1 публикация, 2.78%
Cancer Gene Therapy	Cancer Gene Therapy, 1, 2.78% Cancer Gene Therapy 1 публикация, 2.78%
Current Opinion in Immunology	Current Opinion in Immunology, 1, 2.78% Current Opinion in Immunology 1 публикация, 2.78%
Bratislava Medical Journal	Bratislava Medical Journal, 1, 2.78% Bratislava Medical Journal 1 публикация, 2.78%
Frontiers in Immunology	Frontiers in Immunology, 1, 2.78% Frontiers in Immunology 1 публикация, 2.78%
Biocatalysis and Agricultural Biotechnology	Biocatalysis and Agricultural Biotechnology, 1, 2.78% Biocatalysis and Agricultural Biotechnology 1 публикация, 2.78%
	1 2 3 4

Издатели

	1 2 3 4 5 6 7 8 9
Elsevier	Elsevier, 9, 25% Elsevier 9 публикаций, 25%
MDPI	MDPI, 7, 19.44% MDPI 7 публикаций, 19.44%
Frontiers Media S.A.	Frontiers Media S.A., 4, 11.11% Frontiers Media S.A. 4 публикации, 11.11%
Pleiades Publishing	Pleiades Publishing, 4, 11.11% Pleiades Publishing 4 публикации, 11.11%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 8.33% American Chemical Society (ACS) 3 публикации, 8.33%
Springer Nature	Springer Nature, 3, 8.33% Springer Nature 3 публикации, 8.33%
Institute of Biochemistry	Institute of Biochemistry, 2, 5.56% Institute of Biochemistry 2 публикации, 5.56%
SCEEMP	SCEEMP, 1, 2.78% SCEEMP 1 публикация, 2.78%
Wiley	Wiley, 1, 2.78% Wiley 1 публикация, 2.78%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.78% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 публикация, 2.78%
Taylor & Francis	Taylor & Francis, 1, 2.78% Taylor & Francis 1 публикация, 2.78%
	1 2 3 4 5 6 7 8 9

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

PDF

Метрики

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Pokrovskaya M. V. et al. Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions // Pharmaceutics. 2022. Vol. 14. No. 3. p. 599.

ГОСТ со всеми авторами (до 50) Скопировать

Pokrovskaya M. V., Pokrovsky V. S., Aleksandrova S. S., Sokolov N. N., Zhdanov D. D. Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions // Pharmaceutics. 2022. Vol. 14. No. 3. p. 599.

RIS |

Цитировать

RIS Скопировать

TY - JOUR

DO - 10.3390/pharmaceutics14030599

UR - https://doi.org/10.3390/pharmaceutics14030599

TI - Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions

T2 - Pharmaceutics

AU - Pokrovskaya, Marina V

AU - Pokrovsky, Vadim S.

AU - Aleksandrova, Svetlana S

AU - Sokolov, Nikolay N.

AU - Zhdanov, Dmitry D

PY - 2022

DA - 2022/03/09

PB - MDPI

SP - 599

IS - 3

VL - 14

PMID - 35335974

SN - 1999-4923

ER -

BibTex |

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2022_Pokrovskaya,

author = {Marina V Pokrovskaya and Vadim S. Pokrovsky and Svetlana S Aleksandrova and Nikolay N. Sokolov and Dmitry D Zhdanov},

title = {Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions},

journal = {Pharmaceutics},

year = {2022},

volume = {14},

publisher = {MDPI},

month = {mar},

url = {https://doi.org/10.3390/pharmaceutics14030599},

number = {3},

pages = {599},

doi = {10.3390/pharmaceutics14030599}

}

MLA

Цитировать

MLA Скопировать

Pokrovskaya, Marina V., et al. “Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions.” Pharmaceutics, vol. 14, no. 3, Mar. 2022, p. 599. https://doi.org/10.3390/pharmaceutics14030599.