Open Access
Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions
Marina V Pokrovskaya
1
,
Vadim S. Pokrovsky
2, 3, 4
,
Svetlana S Aleksandrova
1
,
Nikolay N. Sokolov
1
,
Dmitry D Zhdanov
1, 2
Publication type: Journal Article
Publication date: 2022-03-09
PubMed ID:
35335974
Pharmaceutical Science
Abstract
L-asparaginases (EC 3.5.1.1) are a family of enzymes that catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. These proteins with different biochemical, physicochemical and pharmacological properties are found in many organisms, including bacteria, fungi, algae, plants and mammals. To date, asparaginases from E. coli and Dickeya dadantii (formerly known as Erwinia chrysanthemi) are widely used in hematology for the treatment of lymphoblastic leukemias. However, their medical use is limited by side effects associated with the ability of these enzymes to hydrolyze L-glutamine, as well as the development of immune reactions. To solve these issues, gene-editing methods to introduce amino-acid substitutions of the enzyme are implemented. In this review, we focused on molecular analysis of the mechanism of enzyme action and to optimize the antitumor activity.
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Metrics
35
Total citations:
35
Citations from 2024:
20
(57.14%)
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BibTex |
MLA
Cite this
GOST
Copy
Pokrovskaya M. V. et al. Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions // Pharmaceutics. 2022. Vol. 14. No. 3. p. 599.
GOST all authors (up to 50)
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Pokrovskaya M. V., Pokrovsky V. S., Aleksandrova S. S., Sokolov N. N., Zhdanov D. D. Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions // Pharmaceutics. 2022. Vol. 14. No. 3. p. 599.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/pharmaceutics14030599
UR - https://doi.org/10.3390/pharmaceutics14030599
TI - Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions
T2 - Pharmaceutics
AU - Pokrovskaya, Marina V
AU - Pokrovsky, Vadim S.
AU - Aleksandrova, Svetlana S
AU - Sokolov, Nikolay N.
AU - Zhdanov, Dmitry D
PY - 2022
DA - 2022/03/09
PB - MDPI
SP - 599
IS - 3
VL - 14
PMID - 35335974
SN - 1999-4923
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Pokrovskaya,
author = {Marina V Pokrovskaya and Vadim S. Pokrovsky and Svetlana S Aleksandrova and Nikolay N. Sokolov and Dmitry D Zhdanov},
title = {Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions},
journal = {Pharmaceutics},
year = {2022},
volume = {14},
publisher = {MDPI},
month = {mar},
url = {https://doi.org/10.3390/pharmaceutics14030599},
number = {3},
pages = {599},
doi = {10.3390/pharmaceutics14030599}
}
Cite this
MLA
Copy
Pokrovskaya, Marina V., et al. “Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions.” Pharmaceutics, vol. 14, no. 3, Mar. 2022, p. 599. https://doi.org/10.3390/pharmaceutics14030599.
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