Open Access
Polymers, volume 12, issue 12, pages 3046
New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance
Chumakova N.A.
1
,
Kuzin Sergei V
1
,
Ivanova T A
1
,
Grigoriev Igor A
2
,
Kostjuk Sergei V.
3, 4, 5
,
Melnikov Mikhail Ya
1
3
Publication type: Journal Article
Publication date: 2020-12-18
PubMed ID:
33353203
General Chemistry
Polymers and Plastics
Abstract
A novel approach based on convolution of the electron paramagnetic resonance (EPR) spectra was used for quantitative study of the release kinetics of paramagnetic dopants from poly(d,l-lactide) films. A non-monotonic dependence of the release rate on time was reliably recorded. The release regularities were compared with the dynamics of polymer structure changes determined by EPR, SEM, and optic microscopy. The data obtained allow for the conclusion that the main factor governing dopant release is the formation of pores connected with the surface. In contrast, the contribution of the dopant diffusion through the polymer matrix is negligible. The dopant release can be divided into two phases: release through surface pores, which are partially closed with time, and release through pores initially formed inside the polymer matrix due to autocatalytic hydrolysis of the polymer and gradually connected to the surface of the sample. For some time, these processes co-occur. The mathematical model of the release kinetics based on pore formation is presented, describing the kinetics of release of various dopants from the polymer films of different thicknesses.
Citations by journals
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1
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5
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Russian Journal of Physical Chemistry B
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Russian Journal of Physical Chemistry B
5 publications, 50%
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Polymers
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Polymers
2 publications, 20%
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Applied Magnetic Resonance
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Applied Magnetic Resonance
1 publication, 10%
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Molecules
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Molecules
1 publication, 10%
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1
2
3
4
5
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Citations by publishers
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1
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3
4
5
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Pleiades Publishing
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Pleiades Publishing
5 publications, 50%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 30%
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Springer Nature
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Springer Nature
1 publication, 10%
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1
2
3
4
5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Chumakova N. et al. New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance // Polymers. 2020. Vol. 12. No. 12. p. 3046.
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Chumakova N., Golubeva E. N., Kuzin S. V., Ivanova T. A., Grigoriev I. A., Kostjuk S. V., Melnikov M. Ya. New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance // Polymers. 2020. Vol. 12. No. 12. p. 3046.
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TY - JOUR
DO - 10.3390/polym12123046
UR - https://doi.org/10.3390%2Fpolym12123046
TI - New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance
T2 - Polymers
AU - Grigoriev, Igor A
AU - Golubeva, Elena N.
AU - Kuzin, Sergei V
AU - Melnikov, Mikhail Ya
AU - Chumakova, N.A.
AU - Ivanova, T A
AU - Kostjuk, Sergei V.
PY - 2020
DA - 2020/12/18 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 3046
IS - 12
VL - 12
PMID - 33353203
SN - 2073-4360
ER -
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@article{2020_Chumakova,
author = {Igor A Grigoriev and Elena N. Golubeva and Sergei V Kuzin and Mikhail Ya Melnikov and N.A. Chumakova and T A Ivanova and Sergei V. Kostjuk},
title = {New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance},
journal = {Polymers},
year = {2020},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2Fpolym12123046},
number = {12},
pages = {3046},
doi = {10.3390/polym12123046}
}
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Chumakova, N.A., et al. “New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance.” Polymers, vol. 12, no. 12, Dec. 2020, p. 3046. https://doi.org/10.3390%2Fpolym12123046.