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volume 19 issue 20 pages 4502

Ultrasensitive Electrical Detection of Hemagglutinin for Point-of-Care Detection of Influenza Virus Based on a CMP-NANA Probe and Top-Down Processed Silicon Nanowire Field-Effect Transistors

Mihee Uhm 1
Jin-Moo Lee 2
Jieun Lee 1
Jung-Han Lee 3
Sungjin Choi 1
Byung-Gook Park 3
Dong Myong Kim 1
Sung Jin Choi 1
Hyun-Sun Mo 1
Yong-Joo Jeong 2
Publication typeJournal Article
Publication date2019-10-17
scimago Q1
wos Q2
SJR0.764
CiteScore8.2
Impact factor3.5
ISSN14243210, 14248220
PubMed ID:  31627298
Biochemistry
Analytical Chemistry
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering
Instrumentation
Abstract

Rather than the internal genome nucleic acids, the biomolecules on the surface of the influenza virus itself should be detected for a more exact and rapid point-of-care yes/no decision for influenza virus-induced infectious diseases. This work demonstrates the ultrasensitive electrical detection of the HA1 domain of hemagglutinin (HA), a representative viral surface protein of the influenza virus, using the top-down complementary metal oxide semiconductor (CMOS) processed silicon nanowire (SiNW) field-effect transistor (FET) configuration. Cytidine-5′-monophospho-N-acetylneuraminic acid (CMP-NANA) was employed as a probe that specifically binds both to the aldehyde self-aligned monolayer on the SiNWs and to HA1 simultaneously. CMP-NANA was serially combined with two kinds of linkers, namely 3-aminopropyltriethoxysilane and glutaraldehyde. The surface functionalization used was verified using the purification of glutathione S-transferase-tagged HA1, contact angle measurement, enzyme-linked immunosorbent assay test, and isoelectric focusing analysis. The proposed functionalized SiNW FET showed high sensitivities of the threshold voltage shift (ΔVT) ~51 mV/pH and the ΔVT = 112 mV (63 mV/decade) with an ultralow detectable range of 1 fM of target protein HA1.

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Uhm M. et al. Ultrasensitive Electrical Detection of Hemagglutinin for Point-of-Care Detection of Influenza Virus Based on a CMP-NANA Probe and Top-Down Processed Silicon Nanowire Field-Effect Transistors // Sensors. 2019. Vol. 19. No. 20. p. 4502.
GOST all authors (up to 50) Copy
Uhm M., Lee J., Lee J., Lee J., Choi S., Park B., Kim D. M., Choi S. J., Mo H., Jeong Y., Kim D. H. Ultrasensitive Electrical Detection of Hemagglutinin for Point-of-Care Detection of Influenza Virus Based on a CMP-NANA Probe and Top-Down Processed Silicon Nanowire Field-Effect Transistors // Sensors. 2019. Vol. 19. No. 20. p. 4502.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/s19204502
UR - https://doi.org/10.3390/s19204502
TI - Ultrasensitive Electrical Detection of Hemagglutinin for Point-of-Care Detection of Influenza Virus Based on a CMP-NANA Probe and Top-Down Processed Silicon Nanowire Field-Effect Transistors
T2 - Sensors
AU - Uhm, Mihee
AU - Lee, Jin-Moo
AU - Lee, Jieun
AU - Lee, Jung-Han
AU - Choi, Sungjin
AU - Park, Byung-Gook
AU - Kim, Dong Myong
AU - Choi, Sung Jin
AU - Mo, Hyun-Sun
AU - Jeong, Yong-Joo
AU - Kim, Dae Hwan
PY - 2019
DA - 2019/10/17
PB - MDPI
SP - 4502
IS - 20
VL - 19
PMID - 31627298
SN - 1424-3210
SN - 1424-8220
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Uhm,
author = {Mihee Uhm and Jin-Moo Lee and Jieun Lee and Jung-Han Lee and Sungjin Choi and Byung-Gook Park and Dong Myong Kim and Sung Jin Choi and Hyun-Sun Mo and Yong-Joo Jeong and Dae Hwan Kim},
title = {Ultrasensitive Electrical Detection of Hemagglutinin for Point-of-Care Detection of Influenza Virus Based on a CMP-NANA Probe and Top-Down Processed Silicon Nanowire Field-Effect Transistors},
journal = {Sensors},
year = {2019},
volume = {19},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/s19204502},
number = {20},
pages = {4502},
doi = {10.3390/s19204502}
}
MLA
Cite this
MLA Copy
Uhm, Mihee, et al. “Ultrasensitive Electrical Detection of Hemagglutinin for Point-of-Care Detection of Influenza Virus Based on a CMP-NANA Probe and Top-Down Processed Silicon Nanowire Field-Effect Transistors.” Sensors, vol. 19, no. 20, Oct. 2019, p. 4502. https://doi.org/10.3390/s19204502.