Open Access

Viruses

, volume 13 , issue 11 , pages 2258

CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions

Vladimir Chulanov ^{1, 2, 3}

Anastasiya Kostyusheva ¹

Sergey Brezgin ^{1, 2}

Natalia Ponomareva ^{1, 4}

Vladimir Gegechkori ⁴

Elena Volchkova ³

Nikolay Pimenov ¹

Dmitry Kostyushev ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 4 affiliations

National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia |

Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia |

Department of Infectious Diseases, Sechenov University, 119991 Moscow, Russia |

⁴

Department of Pharmaceutical and Toxicological Chemistry, Sechenov University, 119991 Moscow, Russia |

Publication type: Journal Article

Publication date: 2021-11-11

MDPI

Viruses

scimago Q1

wos Q2

SJR: 1.145

CiteScore: 7.7

Impact factor: 3.5

ISSN: 19994915

DOI: 10.3390/v13112258

Copy DOI

PubMed ID: 34835064

Infectious Diseases

Virology

Abstract

CRISPR/Cas is a powerful tool for studying the role of genes in viral infections. The invention of CRISPR screening technologies has made it possible to untangle complex interactions between the host and viral agents. Moreover, whole-genome and pathway-specific CRISPR screens have facilitated identification of novel drug candidates for treating viral infections. In this review, we highlight recent developments in the fields of CRISPR/Cas with a focus on the use of CRISPR screens for studying viral infections and identifying new candidate genes to aid development of antivirals.

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GOST |

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GOST Copy

Chulanov V. et al. CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions // Viruses. 2021. Vol. 13. No. 11. p. 2258.

GOST all authors (up to 50) Copy

Chulanov V., Kostyusheva A., Brezgin S., Ponomareva N., Gegechkori V., Volchkova E., Pimenov N., Kostyushev D. CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions // Viruses. 2021. Vol. 13. No. 11. p. 2258.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3390/v13112258

UR - https://doi.org/10.3390/v13112258

TI - CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions

T2 - Viruses

AU - Chulanov, Vladimir

AU - Kostyusheva, Anastasiya

AU - Brezgin, Sergey

AU - Ponomareva, Natalia

AU - Gegechkori, Vladimir

AU - Volchkova, Elena

AU - Pimenov, Nikolay

AU - Kostyushev, Dmitry

PY - 2021

DA - 2021/11/11

PB - MDPI

SP - 2258

IS - 11

VL - 13

PMID - 34835064

SN - 1999-4915

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Chulanov,

author = {Vladimir Chulanov and Anastasiya Kostyusheva and Sergey Brezgin and Natalia Ponomareva and Vladimir Gegechkori and Elena Volchkova and Nikolay Pimenov and Dmitry Kostyushev},

title = {CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions},

journal = {Viruses},

year = {2021},

volume = {13},

publisher = {MDPI},

month = {nov},

url = {https://doi.org/10.3390/v13112258},

number = {11},

pages = {2258},

doi = {10.3390/v13112258}

}

MLA

Cite this

MLA Copy

Chulanov, Vladimir, et al. “CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions.” Viruses, vol. 13, no. 11, Nov. 2021, p. 2258. https://doi.org/10.3390/v13112258.

Publisher

MDPI

Journal

Viruses

scimago Q1

wos Q2

SJR

1.145

CiteScore

7.7

Impact factor

3.5

ISSN

19994915 (Print, Electronic)

Labs

Laboratory of Genetic Technologies

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