Open Access
The impact of tumour pH on cancer progression: strategies for clinical intervention
Carol Ward
1
,
James Meehan
1
,
Mark E Gray
2
,
ALAN F. MURRAY
3
,
David J. Argyle
2
,
IAN H. KUNKLER
1
,
Simon P. Langdon
1
3
School of Engineering, Institute for Integrated Micro and Nano Systems, EH9 3JL Edinburgh, UK
|
Publication type: Journal Article
Publication date: 2020-04-09
scimago Q3
SJR: 0.677
CiteScore: 3.1
Impact factor: —
ISSN: 26923114
PubMed ID:
36046070
Abstract
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets.
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Metrics
126
Total citations:
126
Citations from 2025:
49
(38.89%)
Cite this
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BibTex |
MLA
Cite this
GOST
Copy
Ward C. et al. The impact of tumour pH on cancer progression: strategies for clinical intervention // Exploration of Targeted Anti-tumor Therapy. 2020. Vol. 1. No. 2. pp. 71-100.
GOST all authors (up to 50)
Copy
Ward C., Meehan J., Gray M. E., MURRAY A. F., Argyle D. J., KUNKLER I. H., Langdon S. The impact of tumour pH on cancer progression: strategies for clinical intervention // Exploration of Targeted Anti-tumor Therapy. 2020. Vol. 1. No. 2. pp. 71-100.
Cite this
RIS
Copy
TY - JOUR
DO - 10.37349/etat.2020.00005
UR - https://doi.org/10.37349/etat.2020.00005
TI - The impact of tumour pH on cancer progression: strategies for clinical intervention
T2 - Exploration of Targeted Anti-tumor Therapy
AU - Ward, Carol
AU - Meehan, James
AU - Gray, Mark E
AU - MURRAY, ALAN F.
AU - Argyle, David J.
AU - KUNKLER, IAN H.
AU - Langdon, Simon P.
PY - 2020
DA - 2020/04/09
PB - Open Exploration Publishing
SP - 71-100
IS - 2
VL - 1
PMID - 36046070
SN - 2692-3114
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Ward,
author = {Carol Ward and James Meehan and Mark E Gray and ALAN F. MURRAY and David J. Argyle and IAN H. KUNKLER and Simon P. Langdon},
title = {The impact of tumour pH on cancer progression: strategies for clinical intervention},
journal = {Exploration of Targeted Anti-tumor Therapy},
year = {2020},
volume = {1},
publisher = {Open Exploration Publishing},
month = {apr},
url = {https://doi.org/10.37349/etat.2020.00005},
number = {2},
pages = {71--100},
doi = {10.37349/etat.2020.00005}
}
Cite this
MLA
Copy
Ward, Carol, et al. “The impact of tumour pH on cancer progression: strategies for clinical intervention.” Exploration of Targeted Anti-tumor Therapy, vol. 1, no. 2, Apr. 2020, pp. 71-100. https://doi.org/10.37349/etat.2020.00005.