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Asian Pacific Journal of Tropical Biomedicine
,  volume 14 ,  issue 8 ,  pages 350-358

Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA

Swaraj Kumar Babu 1, 2, 3
, 
Sameer Maharana 3
, 
Satyaranjan Chhatria 2
, 
Dibya Ranjan Sahoo 1
, 
Ashirbad Nanda 4
, 
Satish Kanhar 4
, 
Prativa K Behera 3
, 
Sanjib Mohanty 2, 3
, 
Pradeep Kumar Naik 1
, 
Praveen Kishore Sahu 1, 2, 3
1
 
2
 
Department of Molecular Biology and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India | 
3
 
Molecular & Immunology Laboratory, Infectious Disease Biology Unit, Ispat General Hospital, Rourkela, Odisha, India | 
4
 
Publication type: Journal Article
Publication date: 2024-08-30
scimago Q3
wos Q3
SJR: 0.377
CiteScore: 3.3
Impact factor: 1.7
ISSN: 22211691, 25889222
Abstract
Objective:

To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain (Pf3D7), its clinical isolate (Pf140/SS), and Plasmodium berghei ANKA (PbA).

Methods:

Using ring-stage survival assay, phenotypic assessments, and SYBR-green-based fluorescence assay, the antimalarial activities of noscapine were assessed compared with dihydroartemisinin (DHA) in in vivo and in vitro studies. In addition, hemolysis and cytotoxicity tests were carried out to evaluate its safety. RT-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2 (PfFP-2).

Results:

The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA, with IC50 values of (7.68±0.88) and (5.57±0.74) nM/mL, respectively, and >95% inhibition of PbA infected rats. Noscapine also showed a safe profile, as evidenced by low hemolysis and cytotoxicity even at high concentrations. Moreover, PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS (P<0.01).

Conclusions:

Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles, which may be further explored as a therapeutic candidate for the treatment of malaria.

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GOST Copy
Babu S. K. et al. Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA // Asian Pacific Journal of Tropical Biomedicine. 2024. Vol. 14. No. 8. pp. 350-358.
GOST all authors (up to 50) Copy
Babu S. K., Maharana S., Chhatria S., Sahoo D. R., Nanda A., Kanhar S., Behera P. K., Mohanty S., Naik P. K., Sahu P. K. Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA // Asian Pacific Journal of Tropical Biomedicine. 2024. Vol. 14. No. 8. pp. 350-358.
RIS |
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RIS Copy
TY - JOUR
DO - 10.4103/apjtb.apjtb_342_24
UR - https://journals.lww.com/10.4103/apjtb.apjtb_342_24
TI - Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA
T2 - Asian Pacific Journal of Tropical Biomedicine
AU - Babu, Swaraj Kumar
AU - Maharana, Sameer
AU - Chhatria, Satyaranjan
AU - Sahoo, Dibya Ranjan
AU - Nanda, Ashirbad
AU - Kanhar, Satish
AU - Behera, Prativa K
AU - Mohanty, Sanjib
AU - Naik, Pradeep Kumar
AU - Sahu, Praveen Kishore
PY - 2024
DA - 2024/08/30
PB - Medknow
SP - 350-358
IS - 8
VL - 14
SN - 2221-1691
SN - 2588-9222
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2024_Babu,
author = {Swaraj Kumar Babu and Sameer Maharana and Satyaranjan Chhatria and Dibya Ranjan Sahoo and Ashirbad Nanda and Satish Kanhar and Prativa K Behera and Sanjib Mohanty and Pradeep Kumar Naik and Praveen Kishore Sahu},
title = {Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA},
journal = {Asian Pacific Journal of Tropical Biomedicine},
year = {2024},
volume = {14},
publisher = {Medknow},
month = {aug},
url = {https://journals.lww.com/10.4103/apjtb.apjtb_342_24},
number = {8},
pages = {350--358},
doi = {10.4103/apjtb.apjtb_342_24}
}
MLA
Cite this
MLA Copy
Babu, Swaraj Kumar, et al. “Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA.” Asian Pacific Journal of Tropical Biomedicine, vol. 14, no. 8, Aug. 2024, pp. 350-358. https://journals.lww.com/10.4103/apjtb.apjtb_342_24.