Bioanalysis, volume 10, issue 19, pages 1591-1608
Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
Mark E Obrenovich
1, 2, 3, 4
,
Curtis J Donskey
5, 6
,
Isaac T Schiefer
4
,
Rodolfo Bongiovanni
2
,
Ling Li
7
,
George E Jaskiw
8, 9
1
Pathology & Laboratory Medicine Service, Louis Stokes Cleveland Department of Veteran's Affairs Medical Center, Cleveland, OH, 44106, USA
|
2
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA
|
4
Department of Medicinal & Biological Chemistry, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA
|
5
Infectious Disease Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA
|
8
Psychiatry Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA
|
Publication type: Journal Article
Publication date: 2018-10-08
General Medicine
Clinical Biochemistry
Analytical Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Medical Laboratory Technology
Abstract
Aim: Co-metabolism between a human host and the gastrointestinal microbiota generates many small phenolic molecules such as 3-hydroxy-3-(3-hydroxyphenyl)propanoic acid (3,3-HPHPA), which are reported to be elevated in schizophrenia and autism. Characterization of these chemicals, however, has been limited by analytic challenges. Methodology/results: We applied HPLC to separate and quantify over 50 analytes, including multiple structural isomers of 3,3-HPHPA in human cerebrospinal fluid, serum and urine. Confirmation of identity was provided by NMR, by MS and other detection methods. The highly selective methods support rapid quantification of multiple metabolites and exhibit superior chromatographic behavior. Conclusion: An improved ultra-HPLC–MS/MS and structural approaches can accurately quantify 3,3-HPHPA and related analytes in human biological matrices.
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Obrenovich M. E. et al. Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach // Bioanalysis. 2018. Vol. 10. No. 19. pp. 1591-1608.
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Obrenovich M. E., Donskey C. J., Schiefer I. T., Bongiovanni R., Li L., Jaskiw G. E. Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach // Bioanalysis. 2018. Vol. 10. No. 19. pp. 1591-1608.
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TY - JOUR
DO - 10.4155/bio-2018-0140
UR - https://doi.org/10.4155/bio-2018-0140
TI - Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
T2 - Bioanalysis
AU - Obrenovich, Mark E
AU - Donskey, Curtis J
AU - Schiefer, Isaac T
AU - Bongiovanni, Rodolfo
AU - Li, Ling
AU - Jaskiw, George E
PY - 2018
DA - 2018/10/08
PB - Taylor & Francis
SP - 1591-1608
IS - 19
VL - 10
SN - 1757-6180
SN - 1757-6199
ER -
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@article{2018_Obrenovich,
author = {Mark E Obrenovich and Curtis J Donskey and Isaac T Schiefer and Rodolfo Bongiovanni and Ling Li and George E Jaskiw},
title = {Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach},
journal = {Bioanalysis},
year = {2018},
volume = {10},
publisher = {Taylor & Francis},
month = {oct},
url = {https://doi.org/10.4155/bio-2018-0140},
number = {19},
pages = {1591--1608},
doi = {10.4155/bio-2018-0140}
}
Cite this
MLA
Copy
Obrenovich, Mark E., et al. “Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach.” Bioanalysis, vol. 10, no. 19, Oct. 2018, pp. 1591-1608. https://doi.org/10.4155/bio-2018-0140.