Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery
Publication type: Journal Article
Publication date: 2016-12-13
scimago Q3
wos Q2
SJR: 0.501
CiteScore: 4.8
Impact factor: 3.4
ISSN: 17568919, 17568927
PubMed ID:
27957866
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
In spite of the availability of a large number of anti-inflammatory and analgesic agents, fighting pain and inflammation remains a common problem. The current review article discusses the need of novel therapeutic targets for risk-free anti-inflammatory and analgesic therapy and summarizes some new agents in various stages of drug discovery pipeline. Pyridazin-3(2H)-ones are nitrogen-rich heterocyclic compounds of considerable medicinal interest due to their diverse biological activities. The current review article focuses on progressive development of this attractive scaffold for the design and synthesis of new pyridazinone-based anti-inflammatory and analgesic agents. Mechanistic insights into the anti-inflammatory and analgesic properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
|
|
|
Bioorganic Chemistry
3 publications, 6.98%
|
|
|
Organic Letters
3 publications, 6.98%
|
|
|
Journal of Organic Chemistry
3 publications, 6.98%
|
|
|
Molecules
2 publications, 4.65%
|
|
|
European Journal of Medicinal Chemistry
2 publications, 4.65%
|
|
|
Archiv der Pharmazie
2 publications, 4.65%
|
|
|
Organic and Biomolecular Chemistry
2 publications, 4.65%
|
|
|
International Journal of Molecular Sciences
2 publications, 4.65%
|
|
|
Letters in Organic Chemistry
1 publication, 2.33%
|
|
|
Future Medicinal Chemistry
1 publication, 2.33%
|
|
|
MolBank
1 publication, 2.33%
|
|
|
Chemistry
1 publication, 2.33%
|
|
|
PLoS ONE
1 publication, 2.33%
|
|
|
Journal of Enzyme Inhibition and Medicinal Chemistry
1 publication, 2.33%
|
|
|
European Journal of Pharmacology
1 publication, 2.33%
|
|
|
Journal of Heterocyclic Chemistry
1 publication, 2.33%
|
|
|
Drug Development Research
1 publication, 2.33%
|
|
|
Asian Journal of Organic Chemistry
1 publication, 2.33%
|
|
|
Chemistry - A European Journal
1 publication, 2.33%
|
|
|
Organic Chemistry Frontiers
1 publication, 2.33%
|
|
|
Journal of Pain Research
1 publication, 2.33%
|
|
|
Revista Romana de Medicina de Laborator
1 publication, 2.33%
|
|
|
Russian Chemical Bulletin
1 publication, 2.33%
|
|
|
Journal of the American Chemical Society
1 publication, 2.33%
|
|
|
ChemMedChem
1 publication, 2.33%
|
|
|
Mendeleev Communications
1 publication, 2.33%
|
|
|
Oriental Journal Of Chemistry
1 publication, 2.33%
|
|
|
Frontiers in Pain Research
1 publication, 2.33%
|
|
|
Tetrahedron Letters
1 publication, 2.33%
|
|
|
Advances in Heterocyclic Chemistry
1 publication, 2.33%
|
|
|
1
2
3
|
Publishers
|
1
2
3
4
5
6
7
8
9
|
|
|
Elsevier
9 publications, 20.93%
|
|
|
Wiley
7 publications, 16.28%
|
|
|
American Chemical Society (ACS)
7 publications, 16.28%
|
|
|
MDPI
6 publications, 13.95%
|
|
|
Taylor & Francis
4 publications, 9.3%
|
|
|
Royal Society of Chemistry (RSC)
3 publications, 6.98%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 2.33%
|
|
|
Public Library of Science (PLoS)
1 publication, 2.33%
|
|
|
Walter de Gruyter
1 publication, 2.33%
|
|
|
Springer Nature
1 publication, 2.33%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 2.33%
|
|
|
Oriental Scientific Publishing Company
1 publication, 2.33%
|
|
|
Frontiers Media S.A.
1 publication, 2.33%
|
|
|
1
2
3
4
5
6
7
8
9
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
43
Total citations:
43
Citations from 2025:
8
(18.6%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Singh J., Sharma D., Bansal R. Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery // Future Medicinal Chemistry. 2016. Vol. 9. No. 1. pp. 95-127.
GOST all authors (up to 50)
Copy
Singh J., Sharma D., Bansal R. Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery // Future Medicinal Chemistry. 2016. Vol. 9. No. 1. pp. 95-127.
Cite this
RIS
Copy
TY - JOUR
DO - 10.4155/fmc-2016-0194
UR - https://doi.org/10.4155/fmc-2016-0194
TI - Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery
T2 - Future Medicinal Chemistry
AU - Singh, Jyoti
AU - Sharma, Deepika
AU - Bansal, Ranju
PY - 2016
DA - 2016/12/13
PB - Taylor & Francis
SP - 95-127
IS - 1
VL - 9
PMID - 27957866
SN - 1756-8919
SN - 1756-8927
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Singh,
author = {Jyoti Singh and Deepika Sharma and Ranju Bansal},
title = {Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery},
journal = {Future Medicinal Chemistry},
year = {2016},
volume = {9},
publisher = {Taylor & Francis},
month = {dec},
url = {https://doi.org/10.4155/fmc-2016-0194},
number = {1},
pages = {95--127},
doi = {10.4155/fmc-2016-0194}
}
Cite this
MLA
Copy
Singh, Jyoti, et al. “Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery.” Future Medicinal Chemistry, vol. 9, no. 1, Dec. 2016, pp. 95-127. https://doi.org/10.4155/fmc-2016-0194.