Mn(II) compounds as an alternative to Gd-based MRI probes
Publication type: Journal Article
Publication date: 2019-07-12
scimago Q3
wos Q2
SJR: 0.501
CiteScore: 4.8
Impact factor: 3.4
ISSN: 17568919, 17568927
PubMed ID:
31298575
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
Mn(II) has several favorable physicochemical characteristics and a good toxicity profile, which makes it a viable alternative to the Gd(III)-based MRI contrast agents currently used in clinics. Although many studies have been undertaken in the last 10 years, this is a field of investigation still in rapid and continuous development. This review aims to critically discuss the chemical and magnetic properties of Mn(II) compounds relevant as MRI probes, both small complexes and nanosystems containing a large number of metal centers, the possible approaches for optimizing their efficiency by understanding the role of various molecular parameters that control the relaxation processes, and the most important issues related to stability and kinetic inertness.
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Metrics
121
Total citations:
121
Citations from 2024:
47
(38.84%)
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GOST
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Botta M. et al. Mn(II) compounds as an alternative to Gd-based MRI probes // Future Medicinal Chemistry. 2019. Vol. 11. No. 12. pp. 1461-1483.
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Botta M., Carniato F., Esteban-Gómez D., Platas-Iglesias C., Tei L. Mn(II) compounds as an alternative to Gd-based MRI probes // Future Medicinal Chemistry. 2019. Vol. 11. No. 12. pp. 1461-1483.
Cite this
RIS
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TY - JOUR
DO - 10.4155/fmc-2018-0608
UR - https://doi.org/10.4155/fmc-2018-0608
TI - Mn(II) compounds as an alternative to Gd-based MRI probes
T2 - Future Medicinal Chemistry
AU - Botta, Mauro
AU - Carniato, Fabio
AU - Esteban-Gómez, David
AU - Platas-Iglesias, Carlos
AU - Tei, Lorenzo
PY - 2019
DA - 2019/07/12
PB - Taylor & Francis
SP - 1461-1483
IS - 12
VL - 11
PMID - 31298575
SN - 1756-8919
SN - 1756-8927
ER -
Cite this
BibTex (up to 50 authors)
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@article{2019_Botta,
author = {Mauro Botta and Fabio Carniato and David Esteban-Gómez and Carlos Platas-Iglesias and Lorenzo Tei},
title = {Mn(II) compounds as an alternative to Gd-based MRI probes},
journal = {Future Medicinal Chemistry},
year = {2019},
volume = {11},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.4155/fmc-2018-0608},
number = {12},
pages = {1461--1483},
doi = {10.4155/fmc-2018-0608}
}
Cite this
MLA
Copy
Botta, Mauro, et al. “Mn(II) compounds as an alternative to Gd-based MRI probes.” Future Medicinal Chemistry, vol. 11, no. 12, Jul. 2019, pp. 1461-1483. https://doi.org/10.4155/fmc-2018-0608.