Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond
Publication type: Journal Article
Publication date: 2015-04-29
scimago Q3
wos Q2
SJR: 0.501
CiteScore: 4.8
Impact factor: 3.4
ISSN: 17568919, 17568927
PubMed ID:
25921401
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
Much progress has been made in designing analogues that can potentially confer neuroprotection against debilitating neurodegenerative disorders, yet the multifactorial pathogenesis of this cluster of diseases remains a stumbling block for the successful design of an ‘ultimate’ drug. However, with the growing popularity of the “one drug, multiple targets” paradigm, many researchers have successfully synthesized and evaluated drug-like molecules incorporating a propargylamine function that shows potential to serve as multifunctional drugs or multitarget-directed ligands. It is the aim of this review to highlight the reported activities of these propargylamine derivatives and their prospect to serve as drug candidates for the treatment of neurodegenerative disorders.
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Total citations:
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Citations from 2024:
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(17.98%)
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GOST
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Zindo F. T., Joubert J., Malan S. F. Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond // Future Medicinal Chemistry. 2015. Vol. 7. No. 5. pp. 609-629.
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Zindo F. T., Joubert J., Malan S. F. Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond // Future Medicinal Chemistry. 2015. Vol. 7. No. 5. pp. 609-629.
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TY - JOUR
DO - 10.4155/fmc.15.12
UR - https://doi.org/10.4155/fmc.15.12
TI - Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond
T2 - Future Medicinal Chemistry
AU - Zindo, Frank T
AU - Joubert, Jacques
AU - Malan, Sarel F
PY - 2015
DA - 2015/04/29
PB - Taylor & Francis
SP - 609-629
IS - 5
VL - 7
PMID - 25921401
SN - 1756-8919
SN - 1756-8927
ER -
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BibTex (up to 50 authors)
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@article{2015_Zindo,
author = {Frank T Zindo and Jacques Joubert and Sarel F Malan},
title = {Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond},
journal = {Future Medicinal Chemistry},
year = {2015},
volume = {7},
publisher = {Taylor & Francis},
month = {apr},
url = {https://doi.org/10.4155/fmc.15.12},
number = {5},
pages = {609--629},
doi = {10.4155/fmc.15.12}
}
Cite this
MLA
Copy
Zindo, Frank T., et al. “Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond.” Future Medicinal Chemistry, vol. 7, no. 5, Apr. 2015, pp. 609-629. https://doi.org/10.4155/fmc.15.12.