Basics and recent advances in peptide and protein drug delivery
Publication type: Journal Article
Publication date: 2013-11-14
scimago Q2
wos Q3
SJR: 0.427
CiteScore: 4.1
Impact factor: 2.2
ISSN: 20415990, 20416008
PubMed ID:
24228993
Pharmaceutical Science
Abstract
While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Although oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract. Therefore, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to facilitate oral peptide delivery. Additionally, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonization and agglutination, free peptides are not systemically stable without modifications. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and stability issues. Methods to increase systemic stability and site-specific delivery are also discussed.
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627
Total citations:
627
Citations from 2024:
129
(20.57%)
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GOST
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Bruno B. J., Miller G. D., Lim C. S. Basics and recent advances in peptide and protein drug delivery // Therapeutic Delivery. 2013. Vol. 4. No. 11. pp. 1443-1467.
GOST all authors (up to 50)
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Bruno B. J., Miller G. D., Lim C. S. Basics and recent advances in peptide and protein drug delivery // Therapeutic Delivery. 2013. Vol. 4. No. 11. pp. 1443-1467.
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RIS
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TY - JOUR
DO - 10.4155/tde.13.104
UR - https://doi.org/10.4155/tde.13.104
TI - Basics and recent advances in peptide and protein drug delivery
T2 - Therapeutic Delivery
AU - Bruno, Benjamin J
AU - Miller, Geoffrey D
AU - Lim, Carol S
PY - 2013
DA - 2013/11/14
PB - Taylor & Francis
SP - 1443-1467
IS - 11
VL - 4
PMID - 24228993
SN - 2041-5990
SN - 2041-6008
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Bruno,
author = {Benjamin J Bruno and Geoffrey D Miller and Carol S Lim},
title = {Basics and recent advances in peptide and protein drug delivery},
journal = {Therapeutic Delivery},
year = {2013},
volume = {4},
publisher = {Taylor & Francis},
month = {nov},
url = {https://doi.org/10.4155/tde.13.104},
number = {11},
pages = {1443--1467},
doi = {10.4155/tde.13.104}
}
Cite this
MLA
Copy
Bruno, Benjamin J., et al. “Basics and recent advances in peptide and protein drug delivery.” Therapeutic Delivery, vol. 4, no. 11, Nov. 2013, pp. 1443-1467. https://doi.org/10.4155/tde.13.104.