The International Journal of Tuberculosis and Lung Disease, volume 20, issue 2, pages 187-192
Undertreated HIV and drug-resistant tuberculosis at a referral hospital in Irkutsk, Siberia
Publication type: Journal Article
Publication date: 2016-02-01
Quartile SCImago
— Quartile WOS
—
Impact factor: —
ISSN:
PubMed ID:
26792470
Infectious Diseases
Pulmonary and Respiratory Medicine
Abstract
SETTING
A referral hospital for tuberculosis (TB) in Irkutsk, the Russian Federation.
OBJECTIVE
To describe disease characteristics, treatment and hospital outcomes of TB-HIV (human immunodeficiency virus).
DESIGN
Observational cohort of HIV-infected patients admitted for anti-tuberculosis treatment over 6 months.
RESULTS
A total of 98 patients were enrolled with a median CD4 count of 147 cells/mm(3) and viral load of 205 943 copies/ml. Among patients with drug susceptibility testing (DST) results, 29 (64%) were multidrug-resistant (MDR), including 12 without previous anti-tuberculosis treatment. Nineteen patients were on antiretroviral therapy (ART) at admission, and 10 (13% ART-naïve) were started during hospitalization. Barriers to timely ART initiation included death, in-patient treatment interruption, and patient refusal. Of 96 evaluable patients, 21 (22%) died, 14 (15%) interrupted treatment, and 10 (10%) showed no microbiological or radiographic improvement. Patients with a cavitary chest X-ray (aOR 7.4, 95%CI 2.3-23.7, P = 0.001) or central nervous system disease (aOR 6.5, 95%CI 1.2-36.1, P = 0.03) were more likely to have one of these poor outcomes.
CONCLUSION
High rates of MDR-TB, treatment interruption and death were found in an HIV-infected population hospitalized in Irkutsk. There are opportunities for integration of HIV and TB services to overcome barriers to timely ART initiation, increase the use of anti-tuberculosis regimens informed by second-line DST, and strengthen out-patient diagnosis and treatment networks.
Citations by journals
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2
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PLoS ONE
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PLoS ONE
2 publications, 11.11%
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European Respiratory Journal
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European Respiratory Journal
1 publication, 5.56%
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Acta Biomedica Scientifica
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Acta Biomedica Scientifica, 1, 5.56%
Acta Biomedica Scientifica
1 publication, 5.56%
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AIDS Patient Care and STDs
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AIDS Patient Care and STDs
1 publication, 5.56%
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Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy
1 publication, 5.56%
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Clinical Infectious Diseases
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Clinical Infectious Diseases
1 publication, 5.56%
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Frontiers in Public Health
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Frontiers in Public Health
1 publication, 5.56%
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BMJ Open
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BMJ Open
1 publication, 5.56%
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Presse Medicale
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Presse Medicale
1 publication, 5.56%
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Journal of Global Antimicrobial Resistance
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Journal of Global Antimicrobial Resistance
1 publication, 5.56%
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Tuberculosis
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Tuberculosis
1 publication, 5.56%
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Expert Review of Anti-Infective Therapy
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Expert Review of Anti-Infective Therapy
1 publication, 5.56%
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ACTA Paulista de Enfermagem
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ACTA Paulista de Enfermagem, 1, 5.56%
ACTA Paulista de Enfermagem
1 publication, 5.56%
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Profilakticheskaya Meditsina
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Profilakticheskaya Meditsina
1 publication, 5.56%
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HIV Infection and Immunosuppressive Disorders
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HIV Infection and Immunosuppressive Disorders
1 publication, 5.56%
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Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук
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Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук, 1, 5.56%
Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук
1 publication, 5.56%
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1
2
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Citations by publishers
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1
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3
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Elsevier
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Elsevier
3 publications, 16.67%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
2 publications, 11.11%
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European Respiratory Society (ERS)
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European Respiratory Society (ERS)
1 publication, 5.56%
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Mary Ann Liebert
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Mary Ann Liebert
1 publication, 5.56%
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American Society for Microbiology
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American Society for Microbiology
1 publication, 5.56%
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Oxford University Press
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Oxford University Press
1 publication, 5.56%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 5.56%
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BMJ
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BMJ
1 publication, 5.56%
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Taylor & Francis
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Taylor & Francis
1 publication, 5.56%
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Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo
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Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo, 1, 5.56%
Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo
1 publication, 5.56%
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Media Sphere Publishing Group
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Media Sphere Publishing Group
1 publication, 5.56%
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Baltic Medical Educational Center
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Baltic Medical Educational Center
1 publication, 5.56%
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Infra-M Academic Publishing House
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Infra-M Academic Publishing House, 1, 5.56%
Infra-M Academic Publishing House
1 publication, 5.56%
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1
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3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Heysell S. K. et al. Undertreated HIV and drug-resistant tuberculosis at a referral hospital in Irkutsk, Siberia // The International Journal of Tuberculosis and Lung Disease. 2016. Vol. 20. No. 2. pp. 187-192.
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Heysell S. K., Ogarkov O. B., Zhdanova S., Zorkaltseva E., Shugaeva S., Gratz J., Vitko S., Savilov E. D., Koshcheyev M. E., Houpt E. R. Undertreated HIV and drug-resistant tuberculosis at a referral hospital in Irkutsk, Siberia // The International Journal of Tuberculosis and Lung Disease. 2016. Vol. 20. No. 2. pp. 187-192.
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TY - JOUR
DO - 10.5588/IJTLD.14.0961
UR - https://doi.org/10.5588%2FIJTLD.14.0961
TI - Undertreated HIV and drug-resistant tuberculosis at a referral hospital in Irkutsk, Siberia
T2 - The International Journal of Tuberculosis and Lung Disease
AU - Heysell, S K
AU - Ogarkov, O B
AU - Zhdanova, S
AU - Zorkaltseva, E
AU - Shugaeva, S
AU - Gratz, J
AU - Vitko, S.
AU - Savilov, E D
AU - Koshcheyev, M E
AU - Houpt, E R
PY - 2016
DA - 2016/02/01 00:00:00
PB - International Union Against Tuberculosis and Lung Disease
SP - 187-192
IS - 2
VL - 20
PMID - 26792470
SN - 1027-3719
SN - 1815-7920
ER -
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@article{2016_Heysell,
author = {S K Heysell and O B Ogarkov and S Zhdanova and E Zorkaltseva and S Shugaeva and J Gratz and S. Vitko and E D Savilov and M E Koshcheyev and E R Houpt},
title = {Undertreated HIV and drug-resistant tuberculosis at a referral hospital in Irkutsk, Siberia},
journal = {The International Journal of Tuberculosis and Lung Disease},
year = {2016},
volume = {20},
publisher = {International Union Against Tuberculosis and Lung Disease},
month = {feb},
url = {https://doi.org/10.5588%2FIJTLD.14.0961},
number = {2},
pages = {187--192},
doi = {10.5588/IJTLD.14.0961}
}
Cite this
MLA
Copy
Heysell, S. K., et al. “Undertreated HIV and drug-resistant tuberculosis at a referral hospital in Irkutsk, Siberia.” The International Journal of Tuberculosis and Lung Disease, vol. 20, no. 2, Feb. 2016, pp. 187-192. https://doi.org/10.5588%2FIJTLD.14.0961.