Open Access
Platinum(IV)-based prodrugs as an alternative to Pt(II)-based drugs: synthesis and biological action
Publication type: Journal Article
Publication date: 2023-11-10
scimago Q1
wos Q1
SJR: 0.811
CiteScore: 12.9
Impact factor: 6.0
ISSN: 0036021X, 14684837
DOI:
10.59761/rcr5096
General Chemistry
Abstract
The chemotherapy with cisplatin and its analogues widely used in medical practice is associated with undesirable side effects caused by non-selective ligand exchange and binding of the complexes to various biomolecules in the body. An alernative to classical platinum(II)-based drugs are platinum(IV) prodrugs, that is, platinum(II) complexes additionally modified with diverse biologically active axial ligands, including known pharmaceutical products. In recent years, quite a few studies devoted to the design of effective Pt(IV) prodrugs have been published, with some of the developed agents being markedly superior to clinically used cisplatin and carboplatin in therapeutic efficacy. This review summarizes the synthetic approaches to the design of Pt(IV) prodrugs and modification of the axial ligands. The second part of the review is devoted to the biological activity of Pt(IV) prodrugs reported in the period from 2018 to 2023 and comparison of various approaches to the design of effective anticancer agents based on these compounds.The bibliography includes 239 references.
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10
Total citations:
10
Citations from 2025:
7
(70%)
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GOST
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Spector D. et al. Platinum(IV)-based prodrugs as an alternative to Pt(II)-based drugs: synthesis and biological action // Russian Chemical Reviews. 2023. Vol. 92. No. 10. p. RCR5096.
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Spector D., Bubley A. A., Beloglazkina E. K., Krasnovskaya O. O. Platinum(IV)-based prodrugs as an alternative to Pt(II)-based drugs: synthesis and biological action // Russian Chemical Reviews. 2023. Vol. 92. No. 10. p. RCR5096.
Cite this
RIS
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TY - JOUR
DO - 10.59761/rcr5096
UR - https://rcr.colab.ws/publications/10.59761/RCR5096
TI - Platinum(IV)-based prodrugs as an alternative to Pt(II)-based drugs: synthesis and biological action
T2 - Russian Chemical Reviews
AU - Spector, Daniil
AU - Bubley, Anna A.
AU - Beloglazkina, Elena K.
AU - Krasnovskaya, Olga O.
PY - 2023
DA - 2023/11/10
PB - Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
SP - RCR5096
IS - 10
VL - 92
SN - 0036-021X
SN - 1468-4837
ER -
Cite this
BibTex (up to 50 authors)
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@article{2023_Spector,
author = {Daniil Spector and Anna A. Bubley and Elena K. Beloglazkina and Olga O. Krasnovskaya},
title = {Platinum(IV)-based prodrugs as an alternative to Pt(II)-based drugs: synthesis and biological action},
journal = {Russian Chemical Reviews},
year = {2023},
volume = {92},
publisher = {Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii},
month = {nov},
url = {https://rcr.colab.ws/publications/10.59761/RCR5096},
number = {10},
pages = {RCR5096},
doi = {10.59761/rcr5096}
}
Cite this
MLA
Copy
Spector, Daniil, et al. āPlatinum(IV)-based prodrugs as an alternative to Pt(II)-based drugs: synthesis and biological action.ā Russian Chemical Reviews, vol. 92, no. 10, Nov. 2023, p. RCR5096. https://rcr.colab.ws/publications/10.59761/RCR5096.