Annals of Internal Medicine, volume 175, issue 9, pages 1266-1274

Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19

Christina Barkauskas 1
, 
Garyfallia Poulakou 2
, 
Barnaby E Young 3
, 
David M. Vock 4
, 
Lianne Siegel 4
, 
Nicole Engen 4
, 
Greg Grandits 4
, 
Nilima R Mosaly 5
, 
Andrew M. Vekstein 5
, 
Konstantinos N Syrigos 2
, 
Vasiliki Rapti 2
, 
David C Lye 6
, 
Diong Shiau Hui 7
, 
Lindsay Leither 8
, 
Kirk U. Knowlton 9
, 
Rubria Marines-Price 10
, 
J. Scott Overcash 11
, 
Ioannis Kalomenidis 12
, 
Zafeiria Barmparessou 12
, 
Michael Waters 13
, 
Karla Zepeda 13
, 
Peter Chen 14
, 
Sam Torbati 14
, 
Nicholus Sebudde 15
, 
Alyssa Hughes 16
, 
Sanjay R Bhagani 17
, 
Alison Rodger 17
, 
Uriel Sandkovsky 18
, 
Robert L. Gottlieb 18
, 
Eriobu Nnakelu 19
, 
Barbara Trautner 20
, 
Vidya Menon 21
, 
Michael Matthay 22
, 
Philip Robinson 23
, 
Konstantinos Protopapas 24
, 
Nikolaos Koulouris 25
, 
Amiran Baduashvili 26
, 
Dominique L. Braun 27
, 
Huldrych F. Günthard 28
, 
Srikanth Ramachandruni 29
, 
Robert Kidega 30
, 
Kami Kim 31
, 
Timothy J. Hatlen 32
, 
Andrew N. Phillips 33
, 
Daniel D. Murray 34
, 
Tomas O Jensen 35
, 
Maria L. Padilla 36
, 
Evan X Accardi 36
, 
Katy Shaw Saliba 37
, 
Robin L. Dewar 38
, 
Marc Teitelbaum 39
, 
Ven Natarajan 38
, 
Sylvain Laverdure 40
, 
Helene C. Highbarger 38
, 
M Tauseef Rehman 38
, 
Susan Vogel 41
, 
David Vallée 42
, 
Page Crew 43
, 
Negin Atri 41
, 
Adam J Schechner 39
, 
Sarah Pett 44
, 
Fleur Hudson 44
, 
Jonathan Badrock 44
, 
Giota Touloumi 45
, 
Samuel M. Brown 46
, 
Crystal M. North 47
, 
Christina C. Chang 48
, 
Anthony Kelleher 48
, 
Stephanie Nagy-Agren 49
, 
Shikha Vasudeva 49
, 
David Looney 50
, 
Hien H Nguyen 51
, 
Adriana Sánchez 52
, 
Amy C Weintrob 53
, 
Birgit Grund 54
, 
Shweta Sharma 4
, 
Cavan S. Reilly 4
, 
Roger Paredes 55
, 
Agnieszka Bednarska 56
, 
Norman P Gerry 57
, 
Abdel G. Babiker 44
, 
Victoria J. Davey 58
, 
Annetine C. Gelijns 59
, 
Elizabeth S. Higgs 37
, 
Virginia Kan 60
, 
Gail Matthews 48
, 
B. Taylor Thompson 47
, 
Philippe Legenne 61
, 
Richa Chandra 62
, 
H. Clifford Lane 37
, 
James D. Neaton 4
, 
Jens D. Lundgren 34
, 
David Sahner 63
, 
John Tierney 63
, 
Betsey R. Herpin 63
, 
Mary C Smolskis 63
, 
Laura A Mckay 63
, 
Kelly Cahill 63
, 
Ratna Sardana 63
, 
Sharon Segal Raim 63
, 
Lisa Hensely 63
, 
Joshua Lorenzo 63
, 
Rebecca Mock 63
, 
Judith Zuckerman 63
, 
Mark Miller” 63
, 
Lucy Chung 63
, 
Nayon Kang 63
, 
Stacey J. Adam 64
, 
Sarah Read 64
, 
Ruxandra Draghia-Akli 64
, 
Amy Carlsen 65
, 
Anita Carter 65
, 
Eileen Denning 65
, 
Alain Duchene 65
, 
Kate Eckroth 65
, 
Alex Frase 65
, 
Greg Gandits 65
, 
Merrie Harrison 65
, 
Payton Kaiser 65
, 
Joseph Koopmeiners 65
, 
Sue Meger 65
, 
Thomas Murray 65
, 
Kien Quan 65
, 
Siu Fun Quan 65
, 
Greg Thompson 65
, 
Jamie Walski 65
, 
Deborah Wentworth 65
, 
Alan J. Moskowitz 66
, 
Emilia Bagiella 66
, 
Ellen Moquete 66
, 
Karen O’Sullivan 66
, 
Mary E. Marks 66
, 
Emily Kinzel 66
, 
Gabriela Bedoya 66
, 
Lola Gupta 66
, 
Jessica R. Overbey 66
, 
Maria L Padillia 66
, 
Milerva Santos 66
, 
Marc A. Gillinov 67
, 
Marissa A. Miller 68
, 
Wendy C. Taddei-Peters 68
, 
Kathleen Fenton 68
, 
Michael Mack 69
, 
Mezgebe Berhe 69
, 
Clinton Haley 69
, 
Emma Dishner 69
, 
Christopher Bettacchi 69
, 
Kevin Golden 69
, 
Erin Duhaime 69
, 
Madison Ryan 69
, 
Sarah Burris 69
, 
Catherine Tallmadge 69
, 
Lorie Estrada 69
, 
Felecia Jones 69
, 
Samatha Villa 69
, 
Samatha Wang 69
, 
ROBERT RAVEN 69
, 
Tanquinisha Coleman 69
, 
Laura Clariday 69
, 
Rebecca Baker 69
, 
Mariana Hurutado Rodriguez 69
, 
Nazia Iram 69
, 
Michelle Fresnedo 69
, 
Allyson Davis 69
, 
Kiara Leonard 69
, 
Noelia Ramierez 69
, 
Jon Thammavong 69
, 
Krizia Duque 69
, 
Emma Turner 69
, 
Tammy Fisher 69
, 
Dianna Robinson 69
, 
Desirae Ransom 69
, 
Nicholas Maldonado 69
, 
Erica Lusk 69
, 
Aaron Killian 69
, 
Adriana Palacious 69
, 
Edilia Solis 69
, 
Janet Jerrow 69
, 
Matthew Watts 69
, 
Heather Whitacre 69
, 
Elizabeth Cothran 69
, 
Peter K. Smith 70
, 
Emily R. Ko 70
, 
Grace R Dreyer 70
, 
Neil Stafford 70
, 
Megan Brooks 70
, 
Tatyana Der 70
, 
Marie Witte 70
, 
Ruwan Gamarallage 70
, 
John Franzone 70
, 
Noel Ivey 70
, 
Rebecca H Lumsden 70
, 
Ahmaad Mourad 70
, 
Thomas L Holland 70
, 
Mary Motta 70
, 
Kathleen Lane 70
, 
Lauren M Mcgowan 70
, 
Jennifer Stout 70
, 
Heather Aloor 70
, 
Kennesha M Bragg 70
, 
Barvina Toledo 70
, 
Beth Mclendon Arvik 70
, 
Barbara Bussadori 70
, 
Beth A. Hollister 70
, 
Michelle Griffin 70
, 
Dana M. Giangiacomo 70
, 
Vicente Rodriguez 71
, 
Patrick E. Parrino 72
, 
Stephen Spindel 72
, 
Aditya Bansal 72
, 
Katherine Baumgarten 72
, 
Johnathan Hand 72
, 
Derek Vonderhaar 72
, 
Bobby Nossaman 72
, 
Sylvia Laudun 72
, 
Deanna Ames 72
, 
Shane Broussard 72
, 
Nilmo Hernandez 72
, 
Geralyn Isaac 72
, 
Huan Dinh 72
, 
Yiling Zheng 72
, 
Sonny Tran 72
, 
Hunter Mcdaniel 72
, 
Nicolle Crovetto 72
, 
Emerson Perin 73
, 
Briana Costello 73
, 
Prasad Manian 73
, 
M. Rizwan Sohail 73
, 
Alexander Postalian 73
, 
Punit Hinsu 73
, 
Carolyn Watson 73
, 
J. Chen 73
, 
Melyssa Fink 73
, 
Lydia Sturgis 73
, 
Kim Walker 73
, 
Kim Mahon 73
, 
Jennifer Parenti 73
, 
Casey Kappenman 73
, 
Aryn Knight 73
, 
Jeffrey M. Sturek 74
, 
Andrew Barros 74
, 
Kyle B. Enfield 74
, 
Alexandra Kadl 74
, 
China J Green 74
, 
Rachel M Simon 74
, 
Ashley Fox 74
, 
Kara Thornton 74
, 
Jay H. Traverse 75
, 
Frank Rhame 75
, 
Joshua Huelster 75
, 
Rajesh Kethireddy 75
, 
Julianne Salamanca 75
, 
Christine Majeski 75
, 
Paige Skelton 75
, 
Maria Zarambo 75
, 
Andrea Sarafolean 75
, 
Cathryn Oldmixon 76
, 
Nancy Ringwood 76
, 
Ariela Muzikansky 76
, 
Richard Morse 76
, 
Roy G. Brower 77
, 
Lora A. Reineck 68
, 
Neil R. Aggarwal 68
, 
Karen Bienstock 68
, 
Jay H Steingrub 78
, 
Peter K Hou 79
, 
Jay S Steingrub 80
, 
Mark A. Tidswell 80
, 
Lori-Ann Kozikowski 80
, 
Cynthia Kardos 80
, 
Leslie Desouza 80
, 
Sarah Romain 80
, 
Konstantinos Andromidas 81
, 
Valerie Banner-Goodspeed 81
, 
Michael Bolstad 81
, 
Katherine L. Boyle 81
, 
Payton Cabrera 81
, 
Arnaldo Devilla 81
, 
Joshua C. Ellis 81
, 
Ana Grafals 81
, 
Sharon Hayes 81
, 
Conor Higgins 81
, 
Lisa Kurt 81
, 
Nicholas Kurtzman 81
, 
Kimberly Redman 81
, 
Elinita Rosseto 81
, 
Douglas Scaffidi 81
, 
Nathan Shapiro 81
, 
Daniel Talmor 81
, 
Michael R. Filbin 82
, 
Kathryn A. Hibbert 82
, 
Blair Parry 82
, 
Justin Margolin 82
, 
Brooklynn Hillis 82
, 
Rhonda Hamer 82
, 
Alan E. Jones 83
, 
James Galbraith 83
, 
Utsav Nandi 83
, 
Michael A. Matthay 84
, 
Kirsten Kangelaris 84
, 
Kimia Ashktorab 84
, 
Rachel Gropper 84
, 
Anika Agrawal 84
, 
Eyad Almasri 85
, 
MOHAMED FAYED 85
, 
Kinsley A Hubel 85
, 
Rebekah L Garcia 85
, 
George W Lim 86
, 
Steven Y. Chang 86
, 
Gregory Hendey 86
, 
Michael Y. Lin 86
, 
Julia Vargas 86
, 
Hena Sihota 86
, 
Rebecca Beutler 86
, 
Angela J. Rogers 87
, 
Jennifer G. Wilson 87
, 
Rosemary Vojnik 87
, 
Cynthia Perez 87
, 
Jordan H Mcdowell 87
, 
Timothy Albertson 88
, 
Erin Hardy 88
, 
Richart Harper 88
, 
Marc A Moss 89
, 
Adit A. Ginde 90
, 
Lakshmi Chauhan 90
, 
David J. Douin 90
, 
Flora Martinez 90
, 
Lani L Finck 90
, 
Jill Bastman 90
, 
Robert C. Hyzy 91
, 
Pauline K. Park 91
, 
Kristine Nelson 91
, 
Jake I Mcsparron 91
, 
Ivan N. Co 91
, 
Bonnie R. Wang 91
, 
Jose Jimenez 91
, 
Barbara Sullins 91
, 
Norman Olbrich 91
, 
Lynne D. Richardson 92
, 
Michelle N. Gong 93
, 
Rahul Nair 93
, 
Brenda Lopez 93
, 
Omowunmi Amosu 93
, 
Hiwet Tzehaie 93
, 
William Nkemdirim 93
, 
Sabah Boujid 93
, 
Jarrod M. Mosier 94
, 
Cameron Hypes 94
, 
Elizabeth Salvagio Campbell 94
, 
Billie Bixby 94
, 
Boris Gilson 94
, 
Anitza Lopez 94
, 
R. Duncan Hite 95
, 
THOMAS E. TERNDRUP 96
, 
Herbert P. Wiedemann 97
, 
Kristin Hudock 98
, 
Hammad Tanzeem 98
, 
Harshada More 98
, 
Jamie Martinkovic 98
, 
Susan Sellers 98
, 
Judy Houston 98
, 
Mary Burns 98
, 
Bryce H Robinson 99
, 
Catherine L. Hough 100
, 
Akram Khan 100
, 
Olivia F Krol 100
, 
Emmanuel Mills 100
, 
Kinjal Mistry 100
, 
Genesis Briceno 100
, 
Raju Reddy 100
, 
Kinsley Hubel 100
, 
Tanyalak Parimon 101
, 
Antonina Caudill 101
, 
Brittany Mattison 101
, 
Susan E Jackman 101
, 
Po En Chen 101
, 
Emad Bayoumi 101
, 
Cristabelle Ojukwu 101
, 
Devin Fine 101
, 
Gwendolyn Weissberg 101
, 
Katherine Isip 101
, 
Yunhee Choi-Kuaea 101
, 
Shaunt Mehdikhani 101
, 
Tahir B Dar 101
, 
Fleury Augustin Nsole Biteghe 101
, 
Dana Tran 101
, 
Jennifer Emilow Dukov 101
, 
D. Shane O’Mahony 102
, 
David M. Wilson 102
, 
Julie A Wallick 102
, 
Alexandria M Duven 102
, 
Dakota D Fletcher 102
, 
D. Clark Files 103
, 
Chadwick Miller 103
, 
Kevin W. Gibbs 103
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Lori S Flores 103
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Mary E Larose 103
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Leigha D Landreth 103
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D Rafael Palacios 103
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Lisa Parks 103
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Madeline Hicks 103
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Andrew J. Goodwin 104
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Edward F Kilb 104
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Caitlan T Lematty 104
, 
Kerilyn Patti 104
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Joseph Bledsoe 105
, 
Samuel Brown 105
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Michael Lanspa 105
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Ithan Pelton 105
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Brent P Armbruster 105
, 
Quinn Montgomery 105
, 
Naresh Naresh Kumar (2) 105
, 
Melissa Fergus 105
, 
Karah Imel 105
, 
Ghazal Palmer 105
, 
Brandon Webb 105
, 
Carolyn Klippel 105
, 
Hannah Jensen 105
, 
Sarah Duckworth 105
, 
Andrew Gray 105
, 
Tyler Burke 105
, 
Dan Knox 105
, 
Jenna Lumpkin 105
, 
Valerie T Aston 105
, 
Wesley H. Self 106
, 
Todd W. Rice 106
, 
Jonathan D. Casey 106
, 
Jakea Johnson 106
, 
Margaret Hays 106
, 
Moiz Kasubhai 107
, 
Anjana Pillai 107
, 
Daniel Jean 107
, 
Daniel Sittler 107
, 
Balavenkatesh Kanna 107
, 
Nargis Jilani 107
, 
Francisco Amaro 107
, 
Jessica Santana 107
, 
Aleksandr Lyakovestsky 107
, 
Issa Madhoun 107
, 
Louis Marie Desroches 107
, 
Nicole Amadon 107
, 
Alaa Bahr 107
, 
Imaan Ezzat 107
, 
Maryanne Guerrero 107
, 
Joane Padilla 107
, 
Jessie Fullmer 107
, 
INDERPREET SINGH 107
, 
Syed Hamad Ali Shah 107
, 
Rajeev Narang 108
, 
Polly Mock 108
, 
Melissa Shadle 108
, 
Brenda Hernandez 108
, 
Kevin Welch 108
, 
Andrea Payne 108
, 
Gabriela Ertl 108
, 
Daniel Canario 109
, 
Isabel Barrientos 109
, 
Danielle Goss 109
, 
Mattie Devries 109
, 
Ibidolapo Folowosele 109
, 
Dorothy Garner 110
, 
Mariana Gomez 110
, 
Justin Price 110
, 
Ekta Bansal 110
, 
Jim Wong 110
, 
Jason Faulhaber 110
, 
Tasaduq Fazili 110
, 
Brian Yeary 110
, 
Ruth Ndolo 110
, 
Christina Bryant 110
, 
Bridgette Smigeil 110
, 
Rana Najjar 111
, 
Patrice Jones 111
, 
Julie Nguyen 111
, 
Christina Chin 111
, 
Hassan Taha 112
, 
Salah Najm 112
, 
Christopher Smith 112
, 
Jason Moore 112
, 
Talal Nassar 112
, 
Nick Gallinger 112
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Amy Christian 112
, 
Damber Mauer 112
, 
Ashley Phipps 112
, 
Jordan Coslet 113
, 
Rosalynn Landazuri 113
, 
Jacob Pineda 113
, 
Nicole Uribe 113
, 
Jose Ruiz Garcia 113
, 
Cecilia Barbabosa 113
, 
Kaitlyn Sandler 113
, 
Adrienna Marquez 114
, 
Hanh Chu 114
, 
Kia Lee 114
, 
Kimberly Quillin 114
, 
Andrea Garcia 114
, 
Pauline Lew 114
, 
Maria Andrea Monkeberg 115
, 
Sandra Tabler 115
, 
Eleftherios Mylonakis 116
, 
RALPH ROGERS 116
, 
Fadi Shehadeh 116
, 
Evangelia K. Mylona 116
, 
Matthew Kaczynski 116
, 
Quynh Lam Tran 116
, 
Gregorio Benitez 116
, 
Biswajit Mishra 116
, 
Lewis Oscar Felix 116
, 
Maria Tsikala Vafea 116
, 
Eleftheria Atalla 116
, 
Robin Davies 116
, 
Salma Hedili 116
, 
Britt Harrington 116
, 
Laura Popielski 117
, 
Amy Kambo 117
, 
Kimberley Viens 117
, 
Melissa Turner 117
, 
Michael J Vjecha 117
, 
Alice Osuji 118
, 
Christine Cha 118
, 
Azadeh Mozaffari 118
, 
Rosa Hernandez 118
, 
Mamta K. Jain 119
, 
Barbine Tchamba Agbor Agbor 119
, 
Tianna Petersen 119
, 
Dena Kamel 119
, 
Laura Hansen 119
, 
Angie Garcia 119
, 
Mina Kim 119
, 
Natalie Dellavalle 119
, 
Sonia Gonzales 119
, 
Charurut Somboonwit 120
, 
Asa Oxner 120
, 
Lucy Guerra 120
, 
Thanh Tran 120
, 
Avenette Pinto 120
, 
Betty Anderson 121
, 
Ana Zepeda Gutierrez 121
, 
Dannae Martin 121
, 
Cindi Temblador 121
, 
Avon Cuenca 121
, 
Mario Guerrero 121
, 
Eric Daar 121
, 
Ramiro Correa 121
, 
Gabe Hartnell 121
, 
Glenn Wortmann 122
, 
Saumil Doshi 122
, 
Theresa Moriarty 122
, 
Melissa Gonzales 122
, 
Kristin Garman 122
, 
Jason V Baker 123
, 
Anne Frosch 123
, 
Rachael Goldsmith 123
, 
Hodan Jibrell 123
, 
Melanie Lo 123
, 
Jonathan Klaphake 123
, 
Shari Mackedanz 123
, 
LINH NGO 123
, 
Kelly Garcia Myers 123
, 
Ken M. Kunisaki 124
, 
Miranda Hassler 124
, 
Mary Walquist 124
, 
Michael Augenbraun 125
, 
Jack DeHovitz 125
, 
Mahsa Abassi 126
, 
Anne-Marie Leuck 126
, 
Via Rao 126
, 
KOUSICK BISWAS 127
, 
Cristin Harrington 127
, 
Amanda Garcia 127
, 
Tammy Bremer 127
, 
Tara Burke 127
, 
Brittany Koker 127
, 
Anne Davis Karim 127
, 
David Pittman 127
, 
Shikha S Vasudeva 127
, 
Lavannya Pandit 128
, 
Casey Hines Munson 128
, 
John Van 128
, 
Laura Dillon 128
, 
Yiqun Wang 128
, 
Tracy Ochalek 129
, 
Erin Caldwell 129
, 
Edward Humerickhouse 129
, 
David Boone 129
, 
William McGraw 129
, 
Sanjay R. Mehta 130
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Scott Thompson Johns 130
, 
Melissa St John 130
, 
Jacqueline Raceles 130
, 
Emily Sear 130
, 
Stephen Funk 130
, 
Rosa Cesarini 130
, 
Michelle Fang 130
, 
Keith Nicalo 130
, 
Wonder Drake 131
, 
Beatrice Jones 131
, 
Teresa Holtman 131
, 
Archana Maniar 132
, 
Eric A. Johnson 132
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Lam Nguyen 132
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Michelle T. Tran 132
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Thomas W Barrett 133
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Tera Johnston 133
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John T Huggins 134
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Tatsiana Y Beiko 134
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Heather Y. Hughes 134
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William C. McManigle 134
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Nichole T Tanner 134
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RONALD G. WASHBURN 134
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Magdalena Ardelt 134
, 
Patricia A Tuohy 134
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Jennifer L Mixson 134
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Charles G Hinton 134
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Nicola Thornley 134
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Heather Allen 134
, 
Shannon Elam 134
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Barry Boatman 134
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Brittany J Baber 134
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Rudell Ryant 134
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Brentin Roller 135
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Chinh Nguyen 135
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Amani Morgan Mikail 135
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Marivic Hansen 135
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Paola Lichtenberger 136
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Gio Baracco 136
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Carol Ramos 136
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Lauren Bjork 136
, 
Melyssa Sueiro 136
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Phyllis Tien 137
, 
Heather Freasier 137
, 
Theresa Buck 138
, 
Hafida Nekach 138
, 
Mark Holodniy 139
, 
Aarthi Chary 139
, 
KAN LU 139
, 
Theresa Peters 139
, 
Jessica Lopez 139
, 
Susanna Yu Tan 140
, 
Robert H Lee 140
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Aliya Asghar 140
, 
Tasadduq Karim Karyn Isip 140
, 
Katherine Le 140
, 
Thao Nguyen 140
, 
Shinn Wong 140
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Dorthe Raben 141
, 
Bitten Aagaard 141
, 
Charlotte B Nielsen 141
, 
Katharina Krapp 141
, 
Bente Rosdahl Nykjær 141
, 
Christina Olsson 141
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Katja Lisa Kanne 141
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Anne Louise Grevsen 141
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Zillah Maria Joensen 141
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Ane Bojesen 141
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Frederik Woldbye 141
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Nick E Normand 141
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Thomas Benfield 142
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Clara Lundetoft Clausen 142
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Nichlas Hovmand 142
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Simone Bastrup Israelsen 142
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Katrine Iversen 142
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Caecilie Leding 142
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Karen Brorup Pedersen 142
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Louise Thorlacius Ussing 142
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Michaela Tinggaard 142
, 
Sandra Tingsgård 142
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Jens Ulrik Staehr Jensen 143
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Rikke Overgaard 143
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Ema Rastoder 143
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Christian Heerfordt 143
, 
Caroline Hedsund 143
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Christian Phillip Ronn 143
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Peter Thobias Kamstrup 143
, 
Dorthe Sandbaek Hogsberg 143
, 
Christina Bergsoe 143
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Lars Ostergaard 144
, 
Nina Breinholt Staerke 144
, 
Yordanos Yehdego 144
, 
Ane Sondergaard 144
, 
Isik S. Johansen 145
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Inge K Holden 145
, 
Susan O Lindvig 145
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Marie Helleberg 146
, 
Jan Gerstoft 146
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Ole Kirk 146
, 
Tina Bruun 146
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Tomas Ostergaard Jensen 147
, 
Birgitte Lindegaard Madsen 147
, 
Thomas Ingemann Pedersen 147
, 
Zitta Barrella Harboe 147
, 
Birgit Thorup Roge 148
, 
Thomas Michael Hansen 148
, 
Matilde Kanstrup Glesner 148
, 
Sandra Valborg Lofberg 148
, 
Ariella Denize Nielsen 148
, 
Henrik Nielsen 149
, 
Rikke Krog Thisted 149
, 
Kristine Toft Petersen 149
, 
Maria Ruwald Juhl 149
, 
Daria Podlekareva 150
, 
Stine Johnsen 150
, 
Lothar Wiese 151
, 
Lene Surland Knudsen 151
, 
Maria Exposito 152
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José Badillo 152
, 
Ana Martinez 152
, 
Elena Abad 152
, 
Ana Chamorro 152
, 
Lourdes Mateu 153
, 
Sergio España 153
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Maria Constanza Lucero 153
, 
José Ramón Santos 153
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Gemma Lladós 153
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Cristina Lopez 153
, 
Lydia Carabias 153
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Eduardo Fernández-Cruz 154
, 
Marisa Di Natale 154
, 
Sergiu Padure 154
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Jimena Gomez 154
, 
Cristina Ausin 154
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Eva Cervilla 154
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Héctor Balastegui 154
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Carmen Rodríguez Sainz 154
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Paco López 154
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Mariam Escobar 154
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Leire Balerdi 155
, 
Almudena Legarda 155
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Montserrat Roldan 155
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Laura Letona 155
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José Muñoz 155
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Jose R Arribas 156
, 
Rocio Montejano Sánchez 156
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Beatriz Díaz Pollán 156
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Stefan Mark Stewart 156
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Irene Garcia 156
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Alberto Borobia 156
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Vicente Estrada 157
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Noemi Cabello 157
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M J Nuñez Orantos 157
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I Sagastagoitia 157
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J R Homen 157
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E Orviz 157
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Adrián Sánchez Montalvá 158
, 
Juan Espinosa Pereiro 158
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Pau Bosch Nicolau 158
, 
Fernando Salvador 158
, 
Jose Luis Morales Rull 159
, 
Anna Maria Moreno Pena 159
, 
Cristina Acosta 159
, 
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Mi Ha Kim 39
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Joy Beeler 39
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April Stottlemyer 39
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Olivia Tang 39
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Sharon Vanderpuye 39
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Lindsey Yeon 39
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Molly Buehn 39
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Vanessa Eccard Koons 39
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Sadie Frary 39
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Leah MacDonald 39
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Jennifer Cash 39
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Lisa Hoopengardner 39
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Jessica Linton 39
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Marylu Schaffhauser 39
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Michaela Nelson 39
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Mary Spinelli Nadzam 39
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Calvin Proffitt 39
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Christopher Lee 39
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Theresa Engel 39
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Laura Fontaine 39
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Matt Hohn 39
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Michael Galcik 39
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Weizhong Chang 190
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Brad T. Sherman 190
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Adam W. Rupert 190
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Sharada Paudel 190
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Kyndal Cook 190
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Allison Hazen 190
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Yunden Badralmaa 190
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Kenneth Smith 57
, 
Bhakti Patel 57
, 
Robert Kubernac 57
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Marie L Hoover 57
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Craig Brown 191
, 
Nadine Duchateau 191
, 
Sadie Ellis 191
, 
Adam Flosi 191
, 
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1
 
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Duke Health, Durham, North Carolina | 
2
 
3
 
National Centre for Infectious Diseases, Singapore | 
4
 
5
 
6
 
National Centre for Infectious Diseases, Tan Tock Seng Hospital, Lee Kong Chian School of Medicine, Singapore | 
7
 
National Centre for Infectious Diseases, Tan Tock Seng Hospital, Singapore | 
8
 
Division of Pulmonary and Critical Care, Department of Medicine, Intermountain Medical Center, Salt Lake City, Utah | 
9
 
Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah | 
10
 
11
 
Velocity San Diego, San Diego, California | 
12
 
13
 
Velocity Chula Vista, San Diego, California | 
14
 
Cedars-Sinai Medical Center, Los Angeles, California | 
15
 
Lira Regional Referral Hospital, Lira, Uganda | 
16
 
17
 
Royal Free Hospital, London, England | 
18
 
Baylor Scott & White Health, Dallas, Texas | 
19
 
Institute of Human Virology Nigeria, Abuja, Nigeria | 
20
 
21
 
NYC Health + Hospitals/Lincoln, Bronx, New York | 
22
 
23
 
Hoag Memorial Hospital Presbyterian, Newport Beach, California | 
24
 
25
 
26
 
27
 
28
 
29
 
CHRISTUS Spohn Shoreline Hospital, Corpus Christi, Texas | 
30
 
Gulu Regional Referral Hospital, Gulu, Uganda | 
31
 
32
 
Lundquist Institute for Biomedical Innovation, Torrance, California | 
33
 
34
 
CHIP Center of Excellence for Health, Immunity, and Infections and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark | 
35
 
36
 
37
 
38
 
39
 
Leidos Biomedical Research, Frederick, Maryland | 
40
 
Laboratory of Human Retrovirology and Immunoinformatics, National Institutes of Health, Frederick, Maryland | 
41
 
Office of Clinical Research Policy and Regulatory Operations, National Institutes of Health, Bethesda, Maryland | 
42
 
43
 
Collaborative Clinical Research Branch, National Institutes of Health, Bethesda, Maryland | 
44
 
45
 
46
 
47
 
48
 
49
 
Salem Veterans Affairs Medical Center, Salem, Virginia | 
50
 
The Veterans Medical Research Foundation, San Diego, California | 
51
 
Veterans Affairs Northern California Health Care System, Sacramento, California | 
52
 
Washington Veterans Affairs Medical Center, Washington, DC | 
53
 
Infectious Diseases Section, Washington Veterans Affairs Medical Center, Washington, DC | 
54
 
55
 
Hospital Universitari Germans Trias I Pujol, Badalona, Spain | 
56
 
57
 
Advanced BioMedical Laboratories, Cinnaminson, New Jersey | 
58
 
U.S. Department of Veterans Affairs, Washington, DC | 
59
 
60
 
Infectious Diseases Section, Veterans Affairs Medical Center, Washington, DC | 
61
 
Molecular Partners, Zurich, Switzerland | 
62
 
Novartis, East Hanover Township, New Jersey | 
63
 
64
 
Foundation for the National Institutes of Health, The Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) and Operation Warp Speed
65
 
66
 
67
 
68
 
69
 
Baylor Scott & White Health
70
 
71
 
Lutheran Medical Group
72
 
Ochsner Clinic
73
 
Texas Heart Institute | 
74
 
University of Virginia Health Systems | 
75
 
Minneapolis Heart Institute Foundation | 
76
 
77
 
78
 
ALIGNE Site Coordinating Center (SCC) Lead Investigators, Baystate Medical Center | 
79
 
80
 
Baystate Medical Center
81
 
Beth Israel Deaconess Medical Center
82
 
83
 
University Of Mississippi | 
84
 
85
 
University of California Fresno | 
86
 
87
 
88
 
89
 
90
 
91
 
92
 
Mount Sinai hospital
93
 
Montefiore Medical Center Moses
94
 
Banner University Medical Center Tucson | 
95
 
96
 
97
 
98
 
99
 
100
 
101
 
Cedars-Sinai Medical Center
102
 
Swedish Hospital First Hill
103
 
Wake Forest Baptist Health | 
104
 
Medical Center of South Carolina | 
105
 
Intermountain Medical Center
106
 
107
 
Lincoln Medical center
108
 
CHRISTUS Spohn Shoreline Hospital | 
109
 
Hendrick Medical Center
110
 
Carilion Roanoke Memorial Hospital | 
111
 
Hoag Memorial Hospital Presbyterian
112
 
Cotton O’Neil Clinical Research Center
113
 
Velocity Chula Vista | 
114
 
Velocity San Diego | 
115
 
116
 
The Miriam Hospital
117
 
INSIGHT Washington ICC, Veterans Affairs (VA) Medical Center, Washington, DC | 
118
 
Parkland Health and Hospital Systems
119
 
120
 
121
 
Lundquist Institute for Biomedical Innovation
122
 
MedStar Health Research Institute
123
 
Hennepin Healthcare Research Institute, Minneapolis, Minnesota | 
124
 
Minneapolis VA Medical Center | 
125
 
SUNY DownState Medical Center
126
 
127
 
INSIGHT US Department of Veterans Affairs (VA) ICC
128
 
Michael E. DeBakey VA Medical Center, Houston, Texas | 
129
 
Salem VA Medical Center, Salem, Virginia | 
130
 
VA San Diego Healthcare System | 
131
 
VA TVHS Nashville Campus | 
132
 
133
 
Portland VA Health Care System
134
 
Charles VA Medical Center
135
 
Southern Arizona VA Health Care System | 
136
 
Miami Bruce Carter VA Health Care System
137
 
San Francisco VA Health Care System | 
138
 
Bay Pines VA Healthcare System | 
139
 
Veterans Affairs Palo Alto Health Care System | 
140
 
VA Long Beach Healthcare System | 
141
 
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Herlev-Gentofte Hospital, Respiratory Medicine Section, Department of Internal Medicine | 
144
 
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148
 
Kolding Hospital, Department of Medicine | 
149
 
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Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark | 
151
 
152
 
Spain INSIGHT SCC Spain, Hospital Universitari Germans Trias i Pujol, Badalona | 
153
 
Hospital Universitari Germans Trias i Pujol, Badalona | 
154
 
Hospital General Universitario Gregorio Marañón, Madrid | 
155
 
156
 
Hospital Universitario La Paz, IdiPAZ, Madrid
157
 
Hospital Clínico San Carlos, Madrid
158
 
Hospital Universitary Vall d’Hebron, Barcelona
159
 
Internal Medicine Department, University Hospital Arnau de Vilanova, Lleida | 
160
 
161
 
Georgia SCC, Infectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia | 
162
 
Poland SCC, Wojewodzki Szpital Zakazny Warsaw
163
 
Ukraine Central City Clinical Hospital of Ivano-Frankivsk City, Ukraine | 
164
 
165
 
Tan Tock Seng Hospital, NCID, Singapore | 
166
 
Institute of Human Virology-Nigeria (IHVN)
167
 
Chennai Antiviral Research and Treatment Clinical Research Site, India | 
168
 
INSIGHT SCC Argentina, Coordinación en Investigación Clínica Académica en Latinoamérica
169
 
Hospital General de Agudos JM Ramos Mejia, Buenos Aires
170
 
Hospital Italiano de Buenos Aires, Buenos Aires | 
171
 
Centro de Educacion Medica e Investigaciones Clinicas, Buenos Aires | 
172
 
INSIGHT London ICC, MRC Clinical Trials Unit at UC, London, United Kingdom | 
173
 
United Kingdom SCC: Royal Free Hospital
174
 
Royal Victoria Infirmary
175
 
176
 
177
 
178
 
179
 
180
 
Alexandroupolis General Hospital, Medical School, Democritus University of Thrace | 
181
 
182
 
Gulu Regional Referral Hospital | 
183
 
184
 
Lira Regional Referral Hospital | 
185
 
Masaka Regional Referral Hospital | 
186
 
St. Francis Hospital, Nsambya
187
 
CISPOC: Centro de Investigaçäo e Treino em Saúde da Polana Caniço, Maputo, Mozambique | 
188
 
Gilead Sciences, Foster CIty, California | 
189
 
Molecular Partners and Novartis
190
 
191
 
PCI Pharma Services
Publication type: Journal Article
Publication date: 2022-08-08
Q1
Q1
SJR: 3.337
CiteScore: 23.9
Impact factor: 19.6
ISSN: 00034819, 15393704
General Medicine
Internal Medicine
Abstract
Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection.To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized with COVID-19 compared with standard care alone.Double-blind, randomized, placebo-controlled, clinical trial. (ClinicalTrials.gov: NCT04501978).Multinational, multicenter trial.Adults hospitalized with COVID-19.Intravenous ensovibep, 600 mg, or placebo.Ensovibep was assessed for early futility on the basis of pulmonary ordinal scores at day 5. The primary outcome was time to sustained recovery through day 90, defined as 14 consecutive days at home or place of usual residence after hospital discharge. A composite safety outcome that included death, serious adverse events, end-organ disease, and serious infections was assessed through day 90.An independent data and safety monitoring board recommended that enrollment be halted for early futility after 485 patients were randomly assigned and received an infusion of ensovibep (n = 247) or placebo (n = 238). The odds ratio (OR) for a more favorable pulmonary outcome in the ensovibep (vs. placebo) group at day 5 was 0.93 (95% CI, 0.67 to 1.30; P = 0.68; OR > 1 would favor ensovibep). The 90-day cumulative incidence of sustained recovery was 82% for ensovibep and 80% for placebo (subhazard ratio [sHR], 1.06 [CI, 0.88 to 1.28]; sHR > 1 would favor ensovibep). The primary composite safety outcome at day 90 occurred in 78 ensovibep participants (32%) and 70 placebo participants (29%) (HR, 1.07 [CI, 0.77 to 1.47]; HR < 1 would favor ensovibep).The trial was prematurely stopped because of futility, limiting power for the primary outcome.Compared with placebo, ensovibep did not improve clinical outcomes for hospitalized participants with COVID-19 receiving standard care, including remdesivir; no safety concerns were identified.National Institutes of Health.
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Cite this
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GOST Copy
Barkauskas C. et al. Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 // Annals of Internal Medicine. 2022. Vol. 175. No. 9. pp. 1266-1274.
GOST all authors (up to 50) Copy
Barkauskas C. et al. Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 // Annals of Internal Medicine. 2022. Vol. 175. No. 9. pp. 1266-1274.
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BibTex |
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BibTex (up to 50 authors) Copy
@article{2022_Barkauskas,
author = {Christina Barkauskas and Garyfallia Poulakou and Barnaby E Young and David M. Vock and Lianne Siegel and Nicole Engen and Greg Grandits and Nilima R Mosaly and Andrew M. Vekstein and Konstantinos N Syrigos and Vasiliki Rapti and David C Lye and Diong Shiau Hui and Lindsay Leither and Kirk U. Knowlton and Rubria Marines-Price and J. Scott Overcash and Ioannis Kalomenidis and Zafeiria Barmparessou and Michael Waters and Karla Zepeda and Peter Chen and Sam Torbati and Nicholus Sebudde and Alyssa Hughes and Sanjay R Bhagani and Alison Rodger and Uriel Sandkovsky and Robert L. Gottlieb and Eriobu Nnakelu and Barbara Trautner and Vidya Menon and Michael Matthay and Philip Robinson and Konstantinos Protopapas and Nikolaos Koulouris and Amiran Baduashvili and Dominique L. Braun and Huldrych F. Günthard and Srikanth Ramachandruni and Robert Kidega and Kami Kim and Timothy J. Hatlen and Andrew N. Phillips and Daniel D. Murray and Tomas O Jensen and Maria L. Padilla and Evan X Accardi and Katy Shaw Saliba and Robin L. Dewar and others},
title = {Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19},
journal = {Annals of Internal Medicine},
year = {2022},
volume = {175},
publisher = {American College of Physicians},
month = {aug},
url = {https://doi.org/10.7326/M22-1503},
number = {9},
pages = {1266--1274},
doi = {10.7326/M22-1503}
}
MLA
Cite this
MLA Copy
Barkauskas, Christina, et al. “Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19.” Annals of Internal Medicine, vol. 175, no. 9, Aug. 2022, pp. 1266-1274. https://doi.org/10.7326/M22-1503.
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