Open Access
Angewandte Chemie - International Edition, volume 60, issue 37, pages 20184-20189
Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices
Xu Xinzhao
1
,
Bowen Benjamin J
2
,
Gwyther Rebecca E.A.
2
,
Freeley Mark
1
,
Grigorenko Bella
3, 4
,
Nemukhin Alexander
3, 4
,
Eklöf-Österberg Johnas
5
,
Moth-Poulsen Kasper
5
,
Jones D. Dafydd
2
,
2
Molecular Biosciences Division School of Biosciences Sir Martin Evans Building Cardiff University Cardiff CF10 3AX UK
|
Publication type: Journal Article
Publication date: 2021-08-06
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 14337851, 15213773
General Chemistry
Catalysis
Abstract
Abstract The ability to detect proteins through gating conductance by their unique surface electrostatic signature holds great potential for improving biosensing sensitivity and precision. Two challenges are: (1) defining the electrostatic surface of the incoming ligand protein presented to the conductive surface; (2) bridging the Debye gap to generate a measurable response. Herein, we report the construction of nanoscale protein‐based sensing devices designed to present proteins in defined orientations; this allowed us to control the local electrostatic surface presented within the Debye length, and thus modulate the conductance gating effect upon binding incoming protein targets. Using a β‐lactamase binding protein (BLIP2) as the capture protein attached to carbon nanotube field effect transistors in different defined orientations. Device conductance had influence on binding TEM‐1, an important β‐lactamase involved in antimicrobial resistance (AMR). Conductance increased or decreased depending on TEM‐1 presenting either negative or positive local charge patches, demonstrating that local electrostatic properties, as opposed to protein net charge, act as the key driving force for electrostatic gating. This, in turn can, improve our ability to tune the gating of electrical biosensors toward optimized detection, including for AMR as outlined herein.
Citations by journals
|
1
2
|
|
|
Journal of the American Chemical Society
|
Journal of the American Chemical Society
2 publications, 14.29%
|
|
Molecules
|
Molecules
1 publication, 7.14%
|
|
Journal of Physical Chemistry Letters
|
Journal of Physical Chemistry Letters
1 publication, 7.14%
|
|
Cell Reports Physical Science
|
Cell Reports Physical Science
1 publication, 7.14%
|
|
ACS Sensors
|
ACS Sensors
1 publication, 7.14%
|
|
Nanoscale Advances
|
Nanoscale Advances
1 publication, 7.14%
|
|
Physical Chemistry Chemical Physics
|
Physical Chemistry Chemical Physics
1 publication, 7.14%
|
|
Materials Today Physics
|
Materials Today Physics
1 publication, 7.14%
|
|
Journal of Colloid and Interface Science
|
Journal of Colloid and Interface Science
1 publication, 7.14%
|
|
Materials Advances
|
Materials Advances
1 publication, 7.14%
|
|
Chemistry - A European Journal
|
Chemistry - A European Journal
1 publication, 7.14%
|
|
ChemistrySelect
|
ChemistrySelect
1 publication, 7.14%
|
|
Nano Letters
|
Nano Letters
1 publication, 7.14%
|
|
1
2
|
Citations by publishers
|
1
2
3
4
5
|
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
5 publications, 35.71%
|
|
Elsevier
|
Elsevier
3 publications, 21.43%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
3 publications, 21.43%
|
|
Wiley
|
Wiley
2 publications, 14.29%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 7.14%
|
|
1
2
3
4
5
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[5,9],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["35.71","64.29"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Journal of the American Chemical Society","Molecules","Journal of Physical Chemistry Letters","Cell Reports Physical Science","ACS Sensors","Nanoscale Advances","Physical Chemistry Chemical Physics","Materials Today Physics","Journal of Colloid and Interface Science","Materials Advances","Chemistry - A European Journal","ChemistrySelect","Nano Letters"],"ids":[4813,1770,21963,26452,8271,16663,1773,6071,24202,25900,24708,8021,10312],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[14.29,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["American Chemical Society (ACS)","Elsevier","Royal Society of Chemistry (RSC)","Wiley","Multidisciplinary Digital Publishing Institute (MDPI)"],"ids":[40,17,123,11,202],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[5,3,3,2,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[35.71,21.43,21.43,14.29,7.14],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Xu X. et al. Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices // Angewandte Chemie - International Edition. 2021. Vol. 60. No. 37. pp. 20184-20189.
GOST all authors (up to 50)
Copy
Xu X., Bowen B. J., Gwyther R. E., Freeley M., Grigorenko B., Nemukhin A., Eklöf-Österberg J., Moth-Poulsen K., Jones D. D., Palma M. Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices // Angewandte Chemie - International Edition. 2021. Vol. 60. No. 37. pp. 20184-20189.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/anie.202104044
UR - https://doi.org/10.1002%2Fanie.202104044
TI - Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices
T2 - Angewandte Chemie - International Edition
AU - Gwyther, Rebecca E.A.
AU - Eklöf-Österberg, Johnas
AU - Xu, Xinzhao
AU - Palma, Matteo
AU - Bowen, Benjamin J
AU - Freeley, Mark
AU - Grigorenko, Bella
AU - Nemukhin, Alexander
AU - Moth-Poulsen, Kasper
AU - Jones, D. Dafydd
PY - 2021
DA - 2021/08/06 00:00:00
PB - Wiley
SP - 20184-20189
IS - 37
VL - 60
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex
Copy
@article{2021_Xu,
author = {Rebecca E.A. Gwyther and Johnas Eklöf-Österberg and Xinzhao Xu and Matteo Palma and Benjamin J Bowen and Mark Freeley and Bella Grigorenko and Alexander Nemukhin and Kasper Moth-Poulsen and D. Dafydd Jones},
title = {Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices},
journal = {Angewandte Chemie - International Edition},
year = {2021},
volume = {60},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002%2Fanie.202104044},
number = {37},
pages = {20184--20189},
doi = {10.1002/anie.202104044}
}
Cite this
MLA
Copy
Xu, Xinzhao, et al. “Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices.” Angewandte Chemie - International Edition, vol. 60, no. 37, Aug. 2021, pp. 20184-20189. https://doi.org/10.1002%2Fanie.202104044.