Open Access
Journal of Cell Biology, volume 166, issue 6, pages 775-785
Visualization of early chromosome condensation : a hierarchical folding, axial glue model of chromosome structure
1
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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2
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724
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Publication type: Journal Article
Publication date: 2004-09-07
Journal:
Journal of Cell Biology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.8
ISSN: 00219525, 15408140
PubMed ID:
15353545
Cell Biology
Abstract
Current models of mitotic chromosome structure are based largely on the examination of maximally condensed metaphase chromosomes. Here, we test these models by correlating the distribution of two scaffold components with the appearance of prophase chromosome folding intermediates. We confirm an axial distribution of topoisomerase IIα and the condensin subunit, structural maintenance of chromosomes 2 (SMC2), in unextracted metaphase chromosomes, with SMC2 localizing to a 150–200-nm-diameter central core. In contrast to predictions of radial loop/scaffold models, this axial distribution does not appear until late prophase, after formation of uniformly condensed middle prophase chromosomes. Instead, SMC2 associates throughout early and middle prophase chromatids, frequently forming foci over the chromosome exterior. Early prophase condensation occurs through folding of large-scale chromatin fibers into condensed masses. These resolve into linear, 200–300-nm-diameter middle prophase chromatids that double in diameter by late prophase. We propose a unified model of chromosome structure in which hierarchical levels of chromatin folding are stabilized late in mitosis by an axial “glue.”
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Kireeva N. et al. Visualization of early chromosome condensation : a hierarchical folding, axial glue model of chromosome structure // Journal of Cell Biology. 2004. Vol. 166. No. 6. pp. 775-785.
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Kireeva N., Lakonishok M., Kireev I., Hirano T., Belmont A. S. Visualization of early chromosome condensation : a hierarchical folding, axial glue model of chromosome structure // Journal of Cell Biology. 2004. Vol. 166. No. 6. pp. 775-785.
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TY - JOUR
DO - 10.1083/JCB.200406049
UR - https://doi.org/10.1083%2FJCB.200406049
TI - Visualization of early chromosome condensation : a hierarchical folding, axial glue model of chromosome structure
T2 - Journal of Cell Biology
AU - Kireeva, Natashe
AU - Lakonishok, Margot
AU - Hirano, Tatsuya
AU - Kireev, Igor
AU - Belmont, Andrew S.
PY - 2004
DA - 2004/09/07 00:00:00
PB - Rockefeller University Press
SP - 775-785
IS - 6
VL - 166
PMID - 15353545
SN - 0021-9525
SN - 1540-8140
ER -
Cite this
BibTex
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@article{2004_Kireeva,
author = {Natashe Kireeva and Margot Lakonishok and Tatsuya Hirano and Igor Kireev and Andrew S. Belmont},
title = {Visualization of early chromosome condensation : a hierarchical folding, axial glue model of chromosome structure},
journal = {Journal of Cell Biology},
year = {2004},
volume = {166},
publisher = {Rockefeller University Press},
month = {sep},
url = {https://doi.org/10.1083%2FJCB.200406049},
number = {6},
pages = {775--785},
doi = {10.1083/JCB.200406049}
}
Cite this
MLA
Copy
Kireeva, Natashe, et al. “Visualization of early chromosome condensation : a hierarchical folding, axial glue model of chromosome structure.” Journal of Cell Biology, vol. 166, no. 6, Sep. 2004, pp. 775-785. https://doi.org/10.1083%2FJCB.200406049.
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