Open Access
Antioxidants, volume 8, issue 6, pages 176
Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury
Plotnikov Egor Yu
1, 2, 3
,
Pevzner Irina
1, 2
,
Zorova Ljubava
1, 2
,
Chernikov Valery
4
,
Prusov Andrey
1
,
Kireev Igor
1
,
Silachev Denis
1, 2
,
Skulachev Vladimir
1
,
Zorov Dmitry
1, 2
Publication type: Journal Article
Publication date: 2019-06-14
PubMed ID:
31197113
Biochemistry
Molecular Biology
Cell Biology
Clinical Biochemistry
Physiology
Abstract
Induced and frequently unwanted alterations in the mitochondrial structure and functions are a key component of the pathological cascade in many kidney pathologies, including those associated with acute damage. One of the principal pathogenic elements causing mitochondrial dysfunction in Acute Kidney Injury (AKI) is oxidative stress. After ischemia and nephrotoxic action of drugs, sepsis and systemic inflammation are the most frequent causes of AKI. As the kidney suffers from oxidative stress during sepsis, one of the most promising approaches to alleviate such damaging consequences is the use of antioxidants. Considering administration of lipopolysaccharide (LPS) as a model of sepsis, we demonstrate that the mitochondria of neonatal renal tissue are severely affected by LPS-induced AKI, with pathological ultrastructural changes observed in both the mitochondria of the renal tubular epithelium and the vascular endothelium. Upon mitochondrial damage, we evaluated the effect of the mitochondria-targeted antioxidant plastoquinol decylrhodamine 19 (SkQR1) on the development of acute renal failure in newborn rats associated with systemic inflammation induced by the administration of LPS. We found that SkQR1 administration 3 h before LPS led to decreased urinal expression of the AKI marker neutrophil gelatinase-associated lipocalin 2 (NGAL), in addition to a decrease in urea and creatinine levels in the blood. Additionally, an observed impairment of proliferative activity in the neonatal kidney caused by LPS treatment was also prevented by the treatment of rat pups with SkQR1. Thus, one of the key events for renal tissue damage in neonatal sepsis is an alteration in the structure and function of the mitochondria and the mitochondria-targeted antioxidant SkQR1 is an effective nephroprotective agent, which protects the neonatal kidney from sepsis-induced AKI.
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- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Plotnikov E. Yu. et al. Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury // Antioxidants. 2019. Vol. 8. No. 6. p. 176.
GOST all authors (up to 50)
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Plotnikov E. Yu., Pevzner I., Zorova L., Chernikov V., Prusov A., Kireev I., Silachev D., Skulachev V., Zorov D. Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury // Antioxidants. 2019. Vol. 8. No. 6. p. 176.
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RIS
Copy
TY - JOUR
DO - 10.3390/antiox8060176
UR - https://doi.org/10.3390%2Fantiox8060176
TI - Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury
T2 - Antioxidants
AU - Chernikov, Valery
AU - Kireev, Igor
AU - Prusov, Andrey
AU - Pevzner, Irina
AU - Zorova, Ljubava
AU - Silachev, Denis
AU - Skulachev, Vladimir
AU - Zorov, Dmitry
AU - Plotnikov, Egor Yu
PY - 2019
DA - 2019/06/14 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 176
IS - 6
VL - 8
PMID - 31197113
SN - 2076-3921
ER -
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@article{2019_Plotnikov,
author = {Valery Chernikov and Igor Kireev and Andrey Prusov and Irina Pevzner and Ljubava Zorova and Denis Silachev and Vladimir Skulachev and Dmitry Zorov and Egor Yu Plotnikov},
title = {Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury},
journal = {Antioxidants},
year = {2019},
volume = {8},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fantiox8060176},
number = {6},
pages = {176},
doi = {10.3390/antiox8060176}
}
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MLA
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Plotnikov, Egor Yu., et al. “Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury.” Antioxidants, vol. 8, no. 6, Jun. 2019, p. 176. https://doi.org/10.3390%2Fantiox8060176.
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