Chemico-Biological Interactions, volume 349, pages 109678
New quaternized pyridinium derivatives of betulin: Synthesis and evaluation of membranotropic properties on liposomes, pro- and eukaryotic cells, and isolated mitochondria
Penkov Nikita V.
2
,
Ilzorkina Anna I
4
,
Shakurova Elvira R
3
,
Belosludtsev Konstantin N.
5, 6
,
Semenova Alena A
1
,
Markelova Natalia Y
2
Publication type: Journal Article
Publication date: 2021-11-01
Journal:
Chemico-Biological Interactions
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.1
ISSN: 00092797
General Medicine
Toxicology
Abstract
The present study describes the synthesis of pyridinium derivatives of betulin, including new 4-methyl- and 3,5-methyl-pyridinium analogs, their effect on artificial membrane systems (liposomes), cytotoxicity in models of prokaryotic (E. coli K-12 MG1655) and eukaryotic cells (rat thymocytes), as well as their effect on the functioning of membrane systems of rat liver mitochondria. We have shown that the presence of methyl groups in the pyridine ring of compounds determines the ability of the derivatives to effectively permeabilize the artificial membrane of lecithin liposomes for the fluorescent probe sulforhodamine B. The 4-methyl- and 3,5-methyl-pyridinium analogs inhibit the growth of E. coli K-12 MG1655 and, at the same time, did not have a cytotoxic effect on rat thymocytes. However, in the latter case, we noted a decrease in the mitochondrial potential of cells. The studied compounds reduced the functional activity of mitochondria, suppressing the activity of complexes of the respiratory chain and reducing the membrane potential. In addition, compounds containing methyl groups in the p- and m-positions of the pyridine ring were also able to permeabilize the inner membrane of mitochondria, causing them to swell. In this case, the most lipophilic compound containing two methyl substituents at the m-position of the pyridine fragment was most effective and had a protonophore effect on mitochondria. The paper discusses the dependence of the membranotropic and biological actions of the quaternized pyridine derivatives of betulin on their structure and lipophilicity.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Dubinin M. V. et al. New quaternized pyridinium derivatives of betulin: Synthesis and evaluation of membranotropic properties on liposomes, pro- and eukaryotic cells, and isolated mitochondria // Chemico-Biological Interactions. 2021. Vol. 349. p. 109678.
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Dubinin M. V., Ilzorkina A. I., Markelova N., Penkov N. V., Shakurova E. R., Belosludtsev K. N., Parfenova L. V., Semenova A. A., Markelova N. Y. New quaternized pyridinium derivatives of betulin: Synthesis and evaluation of membranotropic properties on liposomes, pro- and eukaryotic cells, and isolated mitochondria // Chemico-Biological Interactions. 2021. Vol. 349. p. 109678.
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TY - JOUR
DO - 10.1016/j.cbi.2021.109678
UR - https://doi.org/10.1016%2Fj.cbi.2021.109678
TI - New quaternized pyridinium derivatives of betulin: Synthesis and evaluation of membranotropic properties on liposomes, pro- and eukaryotic cells, and isolated mitochondria
T2 - Chemico-Biological Interactions
AU - Dubinin, Mikhail V.
AU - Ilzorkina, Anna I
AU - Markelova, Natalia
AU - Penkov, Nikita V.
AU - Shakurova, Elvira R
AU - Belosludtsev, Konstantin N.
AU - Parfenova, Lyudmila V.
AU - Semenova, Alena A
AU - Markelova, Natalia Y
PY - 2021
DA - 2021/11/01 00:00:00
PB - Elsevier
SP - 109678
VL - 349
SN - 0009-2797
ER -
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@article{2021_Dubinin,
author = {Mikhail V. Dubinin and Anna I Ilzorkina and Natalia Markelova and Nikita V. Penkov and Elvira R Shakurova and Konstantin N. Belosludtsev and Lyudmila V. Parfenova and Alena A Semenova and Natalia Y Markelova},
title = {New quaternized pyridinium derivatives of betulin: Synthesis and evaluation of membranotropic properties on liposomes, pro- and eukaryotic cells, and isolated mitochondria},
journal = {Chemico-Biological Interactions},
year = {2021},
volume = {349},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016%2Fj.cbi.2021.109678},
pages = {109678},
doi = {10.1016/j.cbi.2021.109678}
}