Medical Oncology, volume 31, issue 8, publication number 110
Bacteriophages and medical oncology: targeted gene therapy of cancer
Publication type: Journal Article
Publication date: 2014-07-11
Journal:
Medical Oncology
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.4
ISSN: 13570560, 1559131X
Cancer Research
Oncology
General Medicine
Hematology
Abstract
Targeted gene therapy of cancer is of paramount importance in medical oncology. Bacteriophages, viruses that specifically infect bacterial cells, offer a variety of potential applications in biomedicine. Their genetic flexibility to go under a variety of surface modifications serves as a basis for phage display methodology. These surface manipulations allow bacteriophages to be exploited for targeted delivery of therapeutic genes. Moreover, the excellent safety profile of these viruses paves the way for their potential use as cancer gene therapy platforms. The merge of phage display and combinatorial technology has led to the emergence of phage libraries turning phage display into a high throughput technology. Random peptide libraries, as one of the most frequently used phage libraries, provide a rich source of clinically useful peptide ligands. Peptides are known as a promising category of pharmaceutical agents in medical oncology that present advantages such as inexpensive synthesis, efficient tissue penetration and the lack of immunogenicity. Phage peptide libraries can be screened, through biopanning, against various targets including cancer cells and tissues that results in obtaining cancer-homing ligands. Cancer-specific peptides isolated from phage libraries show huge promise to be utilized for targeting of various gene therapy vectors towards malignant cells. Beyond doubt, bacteriophages will play a more impressive role in the future of medical oncology.
Citations by journals
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2
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Frontiers in Genetics
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Frontiers in Genetics
2 publications, 7.41%
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Advanced Drug Delivery Reviews
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Advanced Drug Delivery Reviews
2 publications, 7.41%
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Molecules
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Molecules
1 publication, 3.7%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 3.7%
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BMC Cancer
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BMC Cancer
1 publication, 3.7%
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Cancer Gene Therapy
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Cancer Gene Therapy
1 publication, 3.7%
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Journal of Pharmaceutical Investigation
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Journal of Pharmaceutical Investigation
1 publication, 3.7%
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Medical Oncology
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Medical Oncology
1 publication, 3.7%
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Journal of the Indian Institute of Science
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Journal of the Indian Institute of Science
1 publication, 3.7%
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Gene
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Gene
1 publication, 3.7%
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Immunological Reviews
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Immunological Reviews
1 publication, 3.7%
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Journal of Physical Chemistry C
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Journal of Physical Chemistry C
1 publication, 3.7%
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Neural Regeneration Research
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Neural Regeneration Research
1 publication, 3.7%
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Drug Delivery
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Drug Delivery
1 publication, 3.7%
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FEMS Microbiology Reviews
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FEMS Microbiology Reviews
1 publication, 3.7%
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Cells
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Cells
1 publication, 3.7%
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Progress in Molecular Biology and Translational Science
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Progress in Molecular Biology and Translational Science
1 publication, 3.7%
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Biotechnology and Applied Biochemistry
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Biotechnology and Applied Biochemistry
1 publication, 3.7%
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Methods in Molecular Biology
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Methods in Molecular Biology
1 publication, 3.7%
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Citations by publishers
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4
5
6
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Springer Nature
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Springer Nature
6 publications, 22.22%
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Elsevier
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Elsevier
4 publications, 14.81%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 11.11%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 7.41%
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Wiley
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Wiley
2 publications, 7.41%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 3.7%
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Wolters Kluwer Health
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Wolters Kluwer Health
1 publication, 3.7%
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Taylor & Francis
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Taylor & Francis
1 publication, 3.7%
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Oxford University Press
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Oxford University Press
1 publication, 3.7%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Bakhshinejad B., Karimi M., Sadeghizadeh M. Bacteriophages and medical oncology: targeted gene therapy of cancer // Medical Oncology. 2014. Vol. 31. No. 8. 110
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Bakhshinejad B., Karimi M., Sadeghizadeh M. Bacteriophages and medical oncology: targeted gene therapy of cancer // Medical Oncology. 2014. Vol. 31. No. 8. 110
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TY - JOUR
DO - 10.1007/s12032-014-0110-9
UR - https://doi.org/10.1007%2Fs12032-014-0110-9
TI - Bacteriophages and medical oncology: targeted gene therapy of cancer
T2 - Medical Oncology
AU - Bakhshinejad, Babak
AU - Karimi, Marzieh
AU - Sadeghizadeh, Majid
PY - 2014
DA - 2014/07/11 00:00:00
PB - Springer Nature
IS - 8
VL - 31
SN - 1357-0560
SN - 1559-131X
ER -
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@article{2014_Bakhshinejad
author = {Babak Bakhshinejad and Marzieh Karimi and Majid Sadeghizadeh},
title = {Bacteriophages and medical oncology: targeted gene therapy of cancer},
journal = {Medical Oncology},
year = {2014},
volume = {31},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007%2Fs12032-014-0110-9},
number = {8},
doi = {10.1007/s12032-014-0110-9}
}