Medical Oncology, volume 31, issue 8, publication number 110

Bacteriophages and medical oncology: targeted gene therapy of cancer

Publication typeJournal Article
Publication date2014-07-11
Journal: Medical Oncology
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor3.4
ISSN13570560, 1559131X
Cancer Research
Oncology
General Medicine
Hematology
Abstract
Targeted gene therapy of cancer is of paramount importance in medical oncology. Bacteriophages, viruses that specifically infect bacterial cells, offer a variety of potential applications in biomedicine. Their genetic flexibility to go under a variety of surface modifications serves as a basis for phage display methodology. These surface manipulations allow bacteriophages to be exploited for targeted delivery of therapeutic genes. Moreover, the excellent safety profile of these viruses paves the way for their potential use as cancer gene therapy platforms. The merge of phage display and combinatorial technology has led to the emergence of phage libraries turning phage display into a high throughput technology. Random peptide libraries, as one of the most frequently used phage libraries, provide a rich source of clinically useful peptide ligands. Peptides are known as a promising category of pharmaceutical agents in medical oncology that present advantages such as inexpensive synthesis, efficient tissue penetration and the lack of immunogenicity. Phage peptide libraries can be screened, through biopanning, against various targets including cancer cells and tissues that results in obtaining cancer-homing ligands. Cancer-specific peptides isolated from phage libraries show huge promise to be utilized for targeting of various gene therapy vectors towards malignant cells. Beyond doubt, bacteriophages will play a more impressive role in the future of medical oncology.

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GOST Copy
Bakhshinejad B., Karimi M., Sadeghizadeh M. Bacteriophages and medical oncology: targeted gene therapy of cancer // Medical Oncology. 2014. Vol. 31. No. 8. 110
GOST all authors (up to 50) Copy
Bakhshinejad B., Karimi M., Sadeghizadeh M. Bacteriophages and medical oncology: targeted gene therapy of cancer // Medical Oncology. 2014. Vol. 31. No. 8. 110
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s12032-014-0110-9
UR - https://doi.org/10.1007%2Fs12032-014-0110-9
TI - Bacteriophages and medical oncology: targeted gene therapy of cancer
T2 - Medical Oncology
AU - Bakhshinejad, Babak
AU - Karimi, Marzieh
AU - Sadeghizadeh, Majid
PY - 2014
DA - 2014/07/11 00:00:00
PB - Springer Nature
IS - 8
VL - 31
SN - 1357-0560
SN - 1559-131X
ER -
BibTex
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BibTex Copy
@article{2014_Bakhshinejad
author = {Babak Bakhshinejad and Marzieh Karimi and Majid Sadeghizadeh},
title = {Bacteriophages and medical oncology: targeted gene therapy of cancer},
journal = {Medical Oncology},
year = {2014},
volume = {31},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007%2Fs12032-014-0110-9},
number = {8},
doi = {10.1007/s12032-014-0110-9}
}
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