Diversity of mechanisms in Ras-GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling

Тип документаJournal Article
Дата публикации2019-01-01
Название журналаOrganic and Biomolecular Chemistry
  • Organic Chemistry
  • Biochemistry
  • Physical and Theoretical Chemistry
Краткое описание

Different mechanisms of GTP hydrolysis by Ras–GAP are revealed in QM/MM simulations depending on molecular groups at position 61 in Ras.

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1. Grigorenko B.L., Kots E.D., Nemukhin A.V. Diversity of mechanisms in Ras–GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling // Organic & Biomolecular Chemistry. 2019. Т. 17. № 19. С. 4879–4891.


DO - 10.1039/c9ob00463g

UR - http://dx.doi.org/10.1039/c9ob00463g

TI - Diversity of mechanisms in Ras–GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling

T2 - Organic & Biomolecular Chemistry

AU - Grigorenko, Bella L.

AU - Kots, Ekaterina D.

AU - Nemukhin, Alexander V.

PY - 2019

PB - Royal Society of Chemistry (RSC)

SP - 4879-4891

IS - 19

VL - 17

SN - 1477-0520

SN - 1477-0539

ER -

BibTex |


doi = {10.1039/c9ob00463g},

url = {https://doi.org/10.1039%2Fc9ob00463g},

year = 2019,

publisher = {Royal Society of Chemistry ({RSC})},

volume = {17},

number = {19},

pages = {4879--4891},

author = {Bella L. Grigorenko and Ekaterina D. Kots and Alexander V. Nemukhin},

title = {Diversity of mechanisms in Ras{\textendash}{GAP} catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling}


Grigorenko, Bella L., Ekaterina D. Kots, and Alexander V. Nemukhin. “Diversity of Mechanisms in Ras–GAP Catalysis of Guanosine Triphosphate Hydrolysis Revealed by Molecular Modeling.” Organic & Biomolecular Chemistry 17.19 (2019): 4879–4891. Crossref. Web.