Open Access
Arkivoc, volume 2017, issue 3, pages 250-268
Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring
Publication type: Journal Article
Publication date: 2017-08-07
Organic Chemistry
Abstract
A direct approach to the synthesis of previously unknown 1H-1,2,3-triazolylfuroxans, involving nucleophilic substitution of the nitro group in nitrofuroxans followed by catalytic [3+2] cycloaddition of intermediate azidofuroxans to 1,3-ketoesters, is reported. The scope of the triazolylfuroxans was additionally diversified through a number of transformations of the functional groups attached to the 1,2,3-triazole ring. The cytotoxic activity of the newly synthesized triazolylfuroxans and of previously reported hetarylfuroxans was studied. The NO-donor capability of selected synthesized hetarylfuroxans was measured by the Griess reaction using a spectrophotometric technique.
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1 publication, 4.55%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kulikov A. S. et al. Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring // Arkivoc. 2017. Vol. 2017. No. 3. pp. 250-268.
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Kulikov A. S., Larin A. A., Fershtat L. L., Anikina L. V., Pukhov S. A., Klochkov S. G., Struchkova M. I., Romanova A. A., Ananyev I. V., Makhova N. N. Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring // Arkivoc. 2017. Vol. 2017. No. 3. pp. 250-268.
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TY - JOUR
DO - 10.24820/ark.5550190.p010.229
UR - https://doi.org/10.24820%2Fark.5550190.p010.229
TI - Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring
T2 - Arkivoc
AU - Kulikov, Alexander S.
AU - Larin, Alexander A
AU - Fershtat, Leonid L
AU - Anikina, Lada V
AU - Pukhov, Sergey A.
AU - Klochkov, Sergey G.
AU - Struchkova, Marina I.
AU - Romanova, Anna A
AU - Ananyev, Ivan V.
AU - Makhova, Nina N
PY - 2017
DA - 2017/08/07 00:00:00
PB - Arkat USA
SP - 250-268
IS - 3
VL - 2017
SN - 1551-7004
SN - 1551-7012
ER -
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@article{2017_Kulikov,
author = {Alexander S. Kulikov and Alexander A Larin and Leonid L Fershtat and Lada V Anikina and Sergey A. Pukhov and Sergey G. Klochkov and Marina I. Struchkova and Anna A Romanova and Ivan V. Ananyev and Nina N Makhova},
title = {Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring},
journal = {Arkivoc},
year = {2017},
volume = {2017},
publisher = {Arkat USA},
month = {aug},
url = {https://doi.org/10.24820%2Fark.5550190.p010.229},
number = {3},
pages = {250--268},
doi = {10.24820/ark.5550190.p010.229}
}
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Kulikov, Alexander S., et al. “Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring.” Arkivoc, vol. 2017, no. 3, Aug. 2017, pp. 250-268. https://doi.org/10.24820%2Fark.5550190.p010.229.