Case Reports In Perinatal Medicine

Ultrafast fiber lasers have shown exceptional performance across various domains, including material processing, medical applications, and optoelectronic communication. The semiconductor saturable absorber mirror (SESAM) is a key enabler of ultrafast laser operation. However, the narrow wavelength range and limited modulation depth of conventional SESAMs pose challenges to further advancing ultrafast fiber laser technology. To address these limitations, we explored the integration of guided mode resonance (GMR) effects to enhance light–matter interaction within the absorption layer. By incorporating subwavelength dielectric film gratings onto the cap layer of SESAMs, we excited GMR and formed a microcavity structure in conjunction with the distributed Bragg mirror (DBR). This design significantly improved the absorption efficiency of InAs quantum dots. The experimental results demonstrate that the modulation depth of the SESAM increased from 6.7% to 17.3%, while the pulse width was reduced by 2.41 times. These improvements facilitated the realization of a high-quality, stable ultrafast fiber laser. This study not only broadens the application potential of ultrafast lasers in diverse fields but also offers a practical pathway for advancing SESAM technology toward industrial-scale deployment.

Bias instability is one of the most critical factors in the performance of spin-exchange relaxation-free (SERF) co-magnetometers. Previous studies on SERF co-magnetometers have shown that changes in the atomic ensemble temperature can lead to variations in the alkali metal atom density, which in turn affect the optical rotation angle and light shift, ultimately influencing the system’s stability. Building on this understanding, this paper introduces the thermoelectric analogy method for the first time in the transient heat transfer analysis of SERF co-magnetometer atomic ensembles. Using this method, the primary factors affecting the atomic ensemble temperature in a SERF co-magnetometer were analyzed, and transient heat transfer models were established for the following processes: the interaction between the non-magnetic electric heating system and the atomic ensemble temperature, laser heating of the atomic ensemble by the optical system, and the effect of environmental temperature changes on the non-magnetic electric heating system. These models were experimentally validated through active temperature variation experiments. The experimental results show that the proposed transient heat transfer models accurately describe the related heat transfer processes of the atomic ensemble, with model fitting accuracy exceeding 98%. This lays a solid foundation for the high-precision closed-loop control of the atomic ensemble temperature in SERF co-magnetometers and provides valuable insights for the structural design and engineering applications of SERF co-magnetometers.

The calibration activities of the COmpact SPectrometer—COSP for the FERMI Free-Electron Laser (FEL) facility at the Elettra Synchrotron (Italy) are presented. COSP is an in-house built grating spectrometer designed to be used during the optimization of the FERMI parameters and to control the relative stability between different FEL harmonics in the multi-harmonic emission mode. The spectrometer is designed to work in single-shot mode at a repetition rate of 50 Hz providing medium resolution in a wide spectral range in order to either measure the separate intensities of the harmonics being mixed in a multi-color experiment or to quantify the amount of possible spurious harmonics. These activities are of key importance in the new class of experiments based on the wave mixing paradigm tested at the seeded FEL FERMI.

Next-generation passive optical networks (NG-PONs) are considered an essential solution for optical architectures, owing to the benefits of energy savings, service transparency, supporting several subscribers, and cost-effectiveness. In this work, a linearly polarized (LP [0,1]) modal bidirectional NG-PON using a graded-index multimode fiber (GIMMF) and free space optics (FSO) is realized. Four downlink/four uplink wavelengths are utilized under the impact of GIMMF nonlinearity, lens losses, and noise with a 100 m FSO link under clear air and weak turbulence. The results depict that a reliable 5.5 km range is obtained at an aggregate symmetric data rate of 40 Gbps. Also, the minimum focal length and lens reflectance of 0.085 m and 12–14.5% in the downlink as well as 0.08 m and 17–19% in the uplink are required, respectively, for a 10−9 bit error rate over a 5 km range. It is also realized that the generated LP modes offer an optimum power fraction of 0.52 to ~1 × 10−11 in the downlink and 0.53 to 1 × 10−10 in the uplink and phase values of 0.23 to 4.79 rad in the downlink and 0.96 to 5.81 rad in the uplink direction. Compared to other systems, the proposed design shows optimum performance and offers a −25.47 dB gain, a 28.84 dB noise figure, a −18.46 dBm output signal, and a 30.51 dB optical signal-to-noise ratio.

In Fourier Transform Spectrometers, phase errors in spectral measurement induce distortion in reconstructed spectra. Existing phase correction algorithms demonstrate insufficient precision in addressing both linear phase and instrumental phase components, resulting in limited applications for the restored spectra in the field of precision measurement. This paper proposes an algorithm called the Cross-Teager–Kaiser ψB Energy Operator–Nonlinear Calibration Model (CTKB-NCM) for phase error correction. The algorithm first uses the cross-Teager–Kaiser ψB energy operator (CTKB) method to correct linear phase errors, then applies the Nonlinear Calibration Model (NCM) to solve for the instrument phase correction parameters at each wavenumber, and finally uses the instrument phase correction parameters to correct the residual phase after the linear phase error has been corrected. The Rao algorithm is used to determine the optimal instrument phase correction parameters. Simulation experiments demonstrate that the CTKB-NCM method achieves an order-of-magnitude improvement in normalized reconstructed spectral accuracy for SO2 gas compared to the conventional Mertz method.

The study of infected biological cells is crucial in modern biomedical research. This work presents a passive sensing approach using optical resonators, designed to detect malignant diseases within a refractive index (RI) range of 1 to 1.5. A comprehensive theoretical analysis is conducted, yielding an expected limit of detection (LoD) ranging from 0.03 nm/RIU to 0.92 nm/RIU. Furthermore, an in-depth investigation of DNA hybridization is performed, incorporating a 1.8 nm linker layer at the analyte boundary. The refractive indices of single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) are 1.456 and 1.529, respectively. The novelty of this work lies in the renaturation process of ssDNA to dsDNA, demonstrated through a labeled sensing modality with a measurable shift in the resonance wavelength spectrum. The proposed surface-functionalized resonators, designed using Silicon-on-Insulator (SOI) technology, include (a) a Rectangular Waveguide-based Ring Resonator (RWRiR), (b) a Rectangular Waveguide-based Racetrack Resonator (RWRaR), (c) a Slot Waveguide-based Ring Resonator (SWRiR), and (d) a Slot Waveguide-based Racetrack Resonator (SWRaR). Among these, the SWRiR exhibits the best performance for DNA sensing, achieving a quality factor (Q-factor) of 2216.714, a sensitivity (S) of 54.282 nm/RIU, and a normalized sensitivity (S’) of 0.0349.

In this paper, we demonstrate a broadband and simultaneous waveguide array light source based on water-soluble CdSe/ZnS quantum dots (QDs). We initially measure the fluorescence intensity for various cladding solution concentrations along the fiber axis to assess their impact on the propagation loss; the experimental results show that the fluorescent intensity decreases with fiber length, with higher concentrations showing a more pronounced decrease. Then, we showcase a synchronous QD light source in an optofluidic chip that fluoresces in red, green, and blue (RGB) within a microfluidic channel. Finally, a 3 × 3 QD array of a fluorescent display on a single PDMS chip is demonstrated. The QD waveguide represents a compact and stable structure that is readily manufacturable, making it an ideal light source for advancing high-throughput biochemical sensing and on-chip spectroscopic analysis.

Light detection and ranging (Lidar) is a key enabling technology for autonomous vehicles and drones. Its emerging implementations are based on photonic integrated circuits (PICs) and optical phased arrays (OPAs). In this work, we introduce a novel approach to the design of OPA Lidar antennas based on Si3N4 grating couplers. The well-established TriPleX platform and the asymmetric double stripe waveguide geometry with full etching are employed, ensuring low complexity and simple fabrication combined with the low-loss advantages of the platform. The design study aims to optimize the performance of the grating coupler-based radiators as well as the OPA, thus enhancing the overall capabilities of Si3N4-based Lidar. Uniform and non-uniform grating structures are considered, achieving θ and φ angle divergences of 0.9° and 32° and 0.54° and 25.41°, respectively. Also, wavelength sensitivity of 7°/100 nm is achieved. Lastly, the fundamental OPA parameters are investigated, and 35 dBi of peak directivity is achieved for an eight-element OPA.

Optical coherence tomography (OCT) is a cellular-resolution imaging technique that can be used as non-invasive and real-time imaging and is useful for detecting early stages of diseases. Five in vitro skin cells were measured by the Mirau-based full-field OCT, including keratinocyte (HaCaT cell line), melanocyte, squamous cell carcinoma cell line (A431), and two melanoma cell lines, i.e., A375 and A2058. Deep learning algorithms (particularly convolutional neural networks, CNN) that extract features from images efficiently process the OCT’s complex images. We used four models to classify the images of five types of 2D-OCT skin cells. Based on the ResNet-15 model, the mean accuracy (average accuracy of 10-fold cross-validation) reaches 98.47%, and the standard deviation is only 0.28% with the data augmentation method. Interestingly, while two normal skin cell images mix and the other three cancer skin cell images mix, the model still works to identify normal and cancer cell features. The mean accuracy reaches 96.77%. Furthermore, we used k-fold analysis to detect the model reliability and adopt the Gradient-weighted Class Activation Mapping (GRAD-CAM) to explain the discrimination results. The deep learning algorithm is successfully and efficiently applied to discriminate the OCT skin cell images.

Quantum cryptography continues to be an area of significant research and educational interest. Here, a straightforward and reliable approach to both the experimental and theoretical aspects of quantum key distribution is presented, tailored for senior undergraduate students. Focusing on illustrating the essential concepts of the B92 protocol through a combination of optical experiments and custom-developed computational tools, this work offers a thorough exploration of quantum cryptography according to the principles of the B92 protocol.

In this paper, we propose the use of a monolayer graphene metasurface to achieve various excellent functions, such as sensing, slow light, and optical switching through the phenomenon of plasmon-induced transparency (PIT). The designed structure of the metasurface consists of a diamond-shaped cross and a pentagon graphene resonator. We conducted an analysis of the electric field distribution and utilized Lorentz resonance theory to study the PIT window that is generated by the coupling of bright-bright modes. Additionally, by adjusting the Fermi level of graphene, we were able to achieve tunable dual frequency switching modulators. Furthermore, the metasurface also demonstrates exceptional sensing performance, with sensitivity and figure of merit (FOM) reaching values of 3.70 THz/RIU (refractive index unit) and 22.40 RIU-1, respectively. As a result, our numerical findings hold significant guiding significance for the design of outstanding terahertz sensors and photonic devices.

This study focuses on the topographic structure of optical anisotropy maps (theziograms) of dehydrated blood plasma films (facies) to identify and utilize markers for diagnosing self-similarity (multifractality) in the birefringence parameters of supramolecular protein networks. The research is based on the Jones-matrix analytical framework, which describes the formation of polarization-structural speckle fields in polycrystalline blood plasma facies. In the proposed model, algorithms were developed to relate the real and imaginary parts of the complex elements of the Jones matrix to the theziograms of linear and circular birefringence. To experimentally implement these algorithms, a novel optical technology was introduced for polarization-interference registration and phase scanning of the laser speckle field of blood plasma facies. The laser-based Jones-matrix layer-by-layer theziography relies on polarization filtration and the digital recording of interference patterns from microscopic images of blood plasma facies. This process includes digital 2D Fourier reconstruction and phase-by-phase scanning of the object field of complex amplitudes, enabling the acquisition of phase sections of laser polarization-structural speckle field components scattered with varying multiplicities. Jones-matrix images of supramolecular networks, along with their corresponding theziograms of linear and circular birefringence, were obtained for each phase plane. The experimental data derived from laser layer-by-layer Jones-matrix theziography were quantitatively analyzed using two complementary approaches: statistical analysis (central moments of the 1st to 4th orders) and multifractal analysis (spectra of fractal dimension distributions). As a result, the most sensitive markers—namely asymmetry and kurtosis—were identified, highlighting changes in the statistical and scale self-similar structures of the theziograms of linear and circular birefringence in blood plasma facies. The practical aspect of this work is to evaluate the diagnostic potential of the Jones-matrix theziography method for identifying and differentiating changes in the birefringence of supramolecular networks in blood plasma facies caused by the long-term effects of COVID-19. For this purpose, a control group (healthy donors) and three experimental groups of patients, confirmed to have had COVID-19 one-to-three years prior, were formed. Within the framework of evidence-based medicine, the operational characteristics of the method—sensitivity, specificity, and accuracy—were assessed. The method demonstrated excellent accuracy in the differential diagnosis of the long-term effects of COVID-19. This was achieved by statistically analyzing the spectra of fractal dimensions of Jones-matrix theziograms reconstructed in the phase plane of single scattering within the volume of blood plasma facies.

X-ray phase-contrast imaging presents a significant advancement in the field of X-ray imaging, surpassing traditional X-ray absorption imaging in detecting hydrogen substances. It effectively addresses the limitations of the latter in providing contrast for imaging weakly absorbing objects, thereby opening up vast potential applications in biomedical research, materials science, and industrial inspection. This article initially explores the fundamental principles of X-ray phase-contrast imaging and several prevalent imaging techniques. Notably, imaging devices such as grating-based Talbot–Lau interferometers emerge as the most promising in phase-contrast imaging due to their exceptional compatibility and imaging quality. Furthermore, this article introduces key parameters for assessing the quality of grating phase-contrast imaging, specifically image noise and sensitivity, along with their calculation methods. These insights are valuable for optimizing grating-based phase-contrast imaging devices. Lastly, this article examines potential applications and advancements in the key components of X-ray phase-contrast imaging while addressing current challenges and future directions in its technological development. This article aims to provide insights and inspiration for scholars interested in this field.

This review explores two main topics: the state-of-the-art and emerging capabilities of high-peak-power, ultrafast (picosecond and femtosecond) long-wave infrared (LWIR) laser technology based on CO2 gas laser amplifiers, and the current and advanced scientific applications of this laser class. The discussion is grounded in expertise gained at the Accelerator Test Facility (ATF) of Brookhaven National Laboratory (BNL), a leading center for ultrafast, high-power CO2 laser development and a National User Facility with a strong track record in high-intensity physics experiments. We begin by reviewing the status of 9–10 μm CO2 laser technology and its applications, before exploring potential breakthroughs, including the realization of 100 terawatt femtosecond pulses. These advancements will drive ongoing research in electron and ion acceleration in plasma, along with applications in secondary radiation sources and atmospheric energy transport. Throughout the review, we highlight how wavelength scaling of physical effects enhances the capabilities of ultra-intense lasers in the LWIR spectrum, expanding the frontiers of both fundamental and applied science.

This paper investigates the evolution of information entropy (IE) in Hermite–Gaussian correlated Schell-model (HGcSM) beams propagating through a gradient-index (GRIN) fiber using Shannon information theory. Our results reveal that the IE of such beams evolves periodically, with the beam order significantly influencing its initial distribution. Compared with traditional Gaussian Schell-model beams, HGcSM beams exhibit more complex IE dynamics, characterized by periodically emerging low-entropy regions whose IE decreases with increasing beam order. Furthermore, the fiber’s central refractive index and core radius strongly affect the evolution period and fluctuation amplitude of IE. These findings provide a theoretical basis for optimizing partially coherent beams in optical fiber applications.