Laboratory of Experimental Virology

- evaluation of biological qualities of wild-type viral isolates by classical virological methods - cytotoxic properties testing on a panel of secondary human and animal tumor cells

- research for new effective oncolytic strains and evaluation of antitumor activity on human tumor cell lines in vitro and in vivo models - study of the molecular antitumor oncolytic mechanisms - the direct cytotoxic antitumor effect of viral strains and the indirect immunostimulating effect depending on the method of virus administration, infectious dose, treatment scheme and other parameters of virotherapy - evaluation of the correlation between the effectiveness of antitumor virotherapy, virus-mediated activation of the immune system, activation scheme of tumor cell death and toxicological characteristics of the studied Newcastle disease virus strains

- development of methodological solutions related to the optimization of the viral strains cultivation, its preparation for dosage form, related to the choice of storage conditions and the composition of solutions, culture media and other necessary components - development process of the viral substance while maintaining a high antitumor potential, safety for mammals and stability of the genetic material during manipulations for the preparation of the drug prototype - analyses of specificity of the action and toxicity of the virus