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Lab team

Directed design of new coordination compounds with antibacterial properties based on essential metals with biogenic and abiogenic ligands

  1. IR spectroscopy
  2. X-ray diffraction analysis
  3. X-ray phase analysis
  4. UV spectroscopy
  5. NMR spectroscopy
  6. CHNS-elemental analysis
Marina Uvarova 🥼
Head of Laboratory
Irina Lutsenko 🥼
Leading researcher
Varvara Veselova 🥼 🤝
Researcher
Arina Filippova 🥼 🤝
Researcher
Kseniya Koshenskova
Junior researcher
Razvorotneva, Lada Sergeevna
Lada Razvorotneva
Junior researcher
Junior researcher

Research directions

Synthesis of coordination compounds

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Development of methods for the synthesis of new coordination compounds Cu(II), Zn(II), Co(II), Ag(I), Pt(II) with O, N, S-donor ligands, characterization of the obtained compounds by physico-chemical methods, study of their antibacterial properties

Means of delivery of metal complexes

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Development of methods and means of delivery of complex compounds synthesized in the project through the use of composite materials (ionogels) based on biocompatible inorganic and polymer matrices and ionic liquids, including the development of methods for obtaining hybrid ionogels containing transition metal compounds

Preparation of ligands based on boron clusters

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Creation of a group of abiogenic carboxylate and hydroxyl ligands based on closoborate anions, including perhalogenated derivatives of boron clusters capable of exhibiting antimicrobial activity against antibiotic-resistant strains of microorganisms; determination of structural features of coordination compounds containing polyhedral boron anions as ligands; elucidation of the nature of the interaction of a metal atom with boron-containing carboxylate and hydroxyl ligands;

Publications and patents

Uvarova M.A., Lutsenko I., Shmelev M., Bekker O., Lashkin A.I., Shender V.O., Nefedov S., Eremenko I.
New Journal of Chemistry scimago Q2 wos Q2
2024-01-01 citations by CoLab: 7 Abstract  
A series of copper(II) complexes with different anions of composition [CuPhen(Hpz)2X2] (Phen = 1,10-phenanthroline; Hpz = pyrazolе; Х= CF3COO- (1), - Otf- (2), Cl- (3), Otf= CF3SO3) have been synthesized....
Uvarova M.A., Nikiforova M.E., Shmelev M.A., Aliev T.M., Metlin M.T., Taydakov I.V., Bekker O.B., Levitskiy O.A., Magdesieva T.V., Rusinov G.L., Belyaev D.V., Vakhrusheva D.V., Krasnoborova S.Y., Kiskin M.A., Lutsenko I.A., et. al.
Inorganica Chimica Acta scimago Q2 wos Q2
2024-07-01 citations by CoLab: 3 Abstract  
Several ternary complexes of rare earth ions (Gd3+, Eu3+, Sm3+) with 3-furoic (H3fur) / 5-nitro-2-furoic (Hnfur) acids and 1,10-phenanthroline (phen) have been synthesized. According to the X-ray data the resulting complexes can be divided into two groups − heterocarboxylate [Ln2(3fur)4(OAc)2(phen)2]·L and homocarboxylate complexes [Ln2(nfur)6(phen)2]·L (LnIII = Gd (1, 2), Eu (3, 4), Sm (5, 6, 7); L = 4EtOH (1–4), 4MeOH (5), H2O (7)). The stability of the complexes 1–6 in solutions was studied by recording electronic absorption spectra for two days. Optical properties of the complexes 1–6 were studied by recording absorption, excitation and luminescence spectra. The study of antibacterial properties 1–7 showed high activity of complexes in vitro against non-pathogenic Mycolicibacterium smegmatis. For the most active 3, antibacterial activity against the reference strain Mycobacterium tuberculosis H37Rv was determined (minimum inhibitory concentration (MIC) up to 12.5 μg/mL). .
Koshenskova K.A., Baravikov D.E., Kayukova L.A., Ergalieva E.M., Nelyubina Y.V., Nikiforova M.E., Dolgushin F.M., Fedin M.V., Bekker O.B., Shender V.O., Malyants I.K., Aliev T.M., Titov K.O., Eremenko I.L., Lutsenko I.A.
Polyhedron scimago Q3 wos Q2
2024-03-01 citations by CoLab: 4 Abstract  
Two cationic and molecular copper(II) complexes - mixed ligand [{Cu(phen)2benz}{Cu(phen)2Cl}]2+·2Cl-·benz-·H3O+·4·.5H2O (1), [Cu(benz)2phen] (2) (benz- = m-Cl-benzoate anion; phen = 1,10-phenantroline) and [Cu(phen)3]2+·2OTf-·2EtOH (3) (OTf = trifluoromethylsulfonate, triflate anion, CF3SO3-) were synthesized using various synthetic approaches and thoroughly characterized by spectroscopic methods and single crystal X-ray diffraction analysis. The structures of the complexes according to X-ray diffraction data are characterized by a diverse geometric environment of the complexing agent - the cationic form of 1 comprises two structurally nonequivalent moieties: the Cu (1) and Cu (2) complex-forming atoms coordinate, in chelate manner, two phen moieties each and the benz- (1)/Cl- (2) anions, respectively, thus forming different-ligand formula units, a trigonal–bipyramidal {Cu(1)N4Cl} and a pseudo octahedral one {Cu(2)N4O2}. The copper(II) ion in the complex 2 coordinates one phen ligand in a bidentate mode and two benz- anions to produce a distorted planar square environment {CuN2O2}. In complex 3, the copper(II) cation is surrounded by three phenanthroline fragments {Cu(phen)3}2+ and non-coordinated OTf- ions. The results of an EPR study 1 show that in the solid phase, intermolecular exchange interactions that cause exchange narrowing of the spectrum are efficient, whereas in solutions, resolved spectra of copper(II) ion with rhombic symmetry of the g-tensor are observed. An in vitro study of the biological properties of 1–3 toward nonpathogenic mycobacterial strain Mycolicibacterium smegmatis showed an increase in biological effectiveness depending on the structure of complexes (MIC, 1 (2 nmol/disk) > 3 (5 nmol/disk) > 2 (12.5 nmol/disk)). Complex 1 was also tested for antitumor activity against an ovarian adenocarcinoma SKOV3 demonstrated high efficiency: the IC50 value is almost 9 times higher than the activity of cisplatin.
Yambulatov D.S., Lutsenko I.A., Baravikov D.E., Dolgushin F.M., Astaf’eva T.V., Bekker O.B., Nersisyan L.G., Samvelyan M.A., Ghochikyan T.V., Kiskin M.A., Eremenko I.L., Ivanov V.K.
Molecules scimago Q1 wos Q2 Open Access
2023-12-23 citations by CoLab: 0 PDF Abstract  
A new silver(I) cluster [Ag8L4(Py)(Pype)]·4Py·11H2O (I) with 3-benzyl-4-phenyl-1,2,4-triazol-5-thiol (L) was synthesized via the direct reaction of AgNO3 and L in MeOH, followed by recrystallization from a pyridine–piperidine mixture. The compound I was isolated in a monocrystal form and its crystal structure was determined via single crystal X-ray diffraction. The complex forms a “butterfly” cluster with triazol-5-thioles. The purity of the silver complex and its stability in the solution was confirmed via NMR analysis. Excitation and emission of the free ligand and its silver complex were studied at room temperature for solid samples. The in vitro biological activity of the free ligand and its complex was studied in relation to the non-pathogenic Mycolicibacterium smegmatis strain. Complexation of the free ligand with silver increases the biological activity of the former by almost twenty times. For the newly obtained silver cluster, a bactericidal effect was established.
Uvarova M.A., Lutsenko I., Babeshkin K.A., Efimov N., Shmelev M., Alexandrov E.V., Sokolov A.V., Eremenko I., Khoroshilov A.V., Kiskin M.A.
CrystEngComm scimago Q2 wos Q1
2023-11-15 citations by CoLab: 6 Abstract  
Four new frameworks were obtained by slow diffusion of a ligand solution - 1,2-bis(4-pyridyl)ethylene (dpe) into solutions of NiII and CoII furoates. It is shown that, depending on the combination...
Uvarova M.A., Baravikov D.E., Dolgushin F.M., Aliev T.M., Titov K.O., Bekker O.B., Lashkin A.I., Malyants I.K., Shender V.O., Kiskin M.A., Eremenko I.L., Lutsenko I.A.
Inorganica Chimica Acta scimago Q2 wos Q2
2023-10-01 citations by CoLab: 2 Abstract  
A series of mononuclear palladium(II) coordination compounds with N-heterocyclic ligands – 1,10-phenanthroline (phen), pyrazole (Hpz), 3,5-dimethylpyrazole (Hdmpz), and anions of 2- / 3-furoic (2-Hfur and 3-Hfur) and trifluoromethanesulfonic (Hotf) acids were obtained. According to the single-crystal X-ray diffraction analysis data in complexes [Pd(Hdmpz)4]⋅2L (L = 2-fur (1); 3-fur (2)), [Pd(3-fur)2(phen)]⋅H2O (3) and [Pd(Hpz)2(phen)]⋅2otf (4), the cation has a square planar environment of N-, O-donor atoms {PdN4} for 1, 2, 4 and {PdN2O2} for 3. The cytotoxic effect of various concentrations of complexes 2, 3 and 4 on human ovarian adenocarcinoma cells (SKOV3) and human dermal fibroblasts (HDF) was measured in vitro. Complex 4 displayed antiproliferative activity against ovarian adenocarcinoma cells, with a six-fold weaker effect on healthy fibroblasts. The antimycobacterial activity of compounds 2-4 was determined in vitro against a non-pathogenic Mycolicibacterium smegmatis strain.
Veselova V.O., Plyuta V.A., Kostrov A.N., Vtyurina D.N., Abramov V.O., Abramova A.V., Voitov Y.I., Padiy D.A., Thu V.T., Hue L.T., Trang D.T., Baranchikov A.E., Khmel I.A., Nadtochenko V.A., Ivanov V.K.
2022-11-09 citations by CoLab: 7 PDF Abstract  
This paper reports the results of the large-scale field testing of composite materials with antibacterial properties in a tropical climate. The composite materials, based on a cotton fabric with a coating of metal oxide nanoparticles (TiO2 and/or ZnO), were produced using high-power ultrasonic treatment. The antibacterial properties of the materials were studied in laboratory tests on solid and liquid nutrient media using bacteria of different taxonomic groups (Escherichia coli, Chromobacterium violaceum, Pseudomonas chlororaphis). On solid media, the coatings were able to achieve a >50% decrease in the number of bacteria. The field tests were carried out in a tropical climate, at the Climate test station “Hoa Lac” (Hanoi city, Vietnam). The composite materials demonstrated long-term antibacterial activity in the tropical climate: the number of microorganisms remained within the range of 1–3% in comparison with the control sample for the duration of the experiment (3 months). Ten of the microorganisms that most frequently occurred on the surface of the coated textiles were identified. The bacteria were harmless, while the fungi were pathogenic and contributed to fabric deterioration. Tensile strength deterioration was also studied, with the fabrics coated with metal oxides demonstrating a better preservation of their mechanical characteristics over time, (there was a 42% tensile strength decrease for the reference non-coated sample and a 21% decrease for the sample with a ZnO + CTAB coating).
Lutsenko I.A., Baravikov D.E., Koshenskova K.A., Kiskin M.A., Nelyubina Y.V., Primakov P.V., Voronina Y.K., Garaeva V.V., Aleshin D.A., Aliev T.M., Danilenko V.N., Bekker O.B., Eremenko I.L.
RSC Advances scimago Q1 wos Q2 Open Access
2022-02-10 citations by CoLab: 29 PDF Abstract  
New complexes of zinc(ii) and copper(ii) with 2-furoic acid (Hfur), acetic acids and N-donor ligands with the compositions [Zn2(fur)4]n, [Zn2(fur)4(NH2py)2], [Zn(fur)2(neoc)], [Zn(OAc)2(neoc)], and [Cu(fur)2(neoc)(H2O)] were synthesized.

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Lab address

Москва, Ленинский проспект, д.31
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