Laboratory of chemotherapy of viral infections

The main areas of activity

·         Study of the mechanism of protective action of effective antiviral compounds. Modeling of the interaction of low molecular weight compounds with targets, molecular docking and the development of criteria for the targeted synthesis of specific ligands. Evaluation of the effectiveness of the developed compounds on computer models, cell-free systems and models of viral infections in cell cultures

·         Primary assessment of acute toxicity of natural and chemical compounds in cell cultures and in animal experiments

·         A targeted search for new virus-inhibiting substances based on the features of the molecular biology of virus reproduction. In vitro screening of chemical libraries and identification of compounds with high antiviral potential in their composition

·         To study the effectiveness of the virucidal activity of the studied substances and devices, including for air disinfection with the possibility of using a separate ventilated sealed box.

·         Evaluation of the specific antiviral activity of natural and chemical compounds in experimental models of viral infections in animals (influenza A and B, parainfluenza, herpes viruses, adenoviruses, enteroviruses and other viruses from 3 and 4 pathogenicity groups). Characteristics of the pathological process caused by a viral infection in the conditions of application of the studied compounds using the necessary virological, morphological, biochemical, immunological and molecular biological techniques.

·         Modeling of various infectious diseases on laboratory animals (small rodents, guinea pigs, hamsters), including SPF categories with the possibility of using an individually ventilated cell system (IVC).

Main achievements:

Over the past 5 years , 53 scientific articles have been published based on research results, and 6 patents of the Russian Federation have been obtained. Research has been conducted on the following projects:

2020 – 2021 RNF Grant No. 20-75-10112 "Transcriptional reprogramming of immunity in viral and bacterial pneumonia: creation of therapy based on cytokine storm modulators" in collaboration with ITMO University.

2021 – 2023. RNF Grant No.21-13-00026 "Design of new agents to combat respiratory syncytial virus in children based on transformations of natural compounds" in collaboration with the Research Institute of the Siberian Branch of the Russian Academy of Sciences.

2022 – 2023 State Assignment "Study of the genetic and antigenic variability of modern strains of respiratory syncytial viruses (RSV) circulating in the territory of the Russian Federation".

2024 - present. RNF Grant No. 24-13-00134 "A new generation of antiviral agents for the treatment of infection caused by respiratory syncytial virus: targeted target-oriented synthesis and study of pharmacological properties in vitro and in vivo."

2024- present State assignment "Molecular biological approaches to the development of a new drug for the treatment of diseases caused by strains of the herpes simplex virus resistant to existing etiotropic drugs, TVKQ-2024-0004".

In 2023, certification according to GOST 33044-2014 was passed. 05/23/98/026 "Principles of Good Laboratory Practice (GLP)"