Enrique Feoli-Tufi

EDUCATION AND BACKGROUND

Graduated MD from the La Sapienza University of Rome, Italy in 1962.

Certified by the American Board of Surgery in 1969.

Assistant of Surgery in the Hospital Mexico de la Caja Costarricense de Seguro Social from 1969 to 1989.

Instructor in the Department of Surgery in the Universidad de Costa Rica from 1970 until 1985, teaching with special interest in wound healing.

A Fellow of the American College of Surgeon in General Surgery since 1970.

Member of the Ethico-Scientific Committee of ULACIT, Universidad Latinoamericana de Ciencia y Tecnología of Costa Rica, since 1999.

Author of five pre-clinical and clinical research publications in local Costa Rican journals.

Micelle stability in primary stones of the biliary common duct

Seat belt syndrome. Case in air crash accident and literature review

Rationale for choledoco-duodenostomy

Healing of inverted intestinal anastomosis built with transfixed nonreversable sutures in dogs

Rationale for sub-clavian vein puncture for venous access and monitoring in seriously ill surgical patients

NOTABLE ACHIEVEMENTS

Papers, publications and journals on Products developed from the Proprietary Patent.

Regenerative healing with Polyactil solution in inflicted skin wounds of pigs

The Low-toxicity of Polyactil Buffer and characterization of therapeutic doses for its multiple ways of administration and delivery

Bone regeneration of cancerous maxilar bone of rats

Vascular effects of the Polyactil Buffer administered at near lethal doses subcutaneously in normotensive rats.

Effect of Periactil in periodontitis occurring in dogs and redirection of Th2 response to a Th1 type and S-IgA secretion in the oropharyngeal mucosa.

Therapeutic effect of Polyactil Buffer in a murine model of persistent eosinophilic inflammation

Prophylaxis of surgical site infections with Polyactil solution. Parts one: open label study with historical controls conducted in abdominal surgery. Part two: series in median sternotomies for cardiovascular surgery with controls; plus series in hip fracture surgery with controls.

Effect of Polyactil in preventing infection of exposed fractures, shortening of evolution and simplification of limb salvage with decrease of secondary amputations.

Effect of Polyactil solution in reversing periodontal disease in cases needing surgical plaque scaling and planning compared with conventional treatment.

OXCP 102 gel effectiveness in preventing oral pathologies, when used prophylatically in rural communities of Costa Rica.

Effect of Polyactil Gel in treating sport lesions in soccer players

Research Protocol for Control of Asthma in Children eliminating the inflammatory response at the epithelia-endothelial level, in upper and smaller airways

Clinical study on the efficacy of Polyactil Gel in preventing decubitis ulcers in bedridden patients. Study planned in the near term.

Clinical study on efficacy of Periactil in preventing oral lesions in patients treated with orthodontic apparatus and diminution of dental plaque

Field study in sows demonstrating how postpartum metritis (inflammation of the uterus) can be treated with MetriHeal improving fertility in swine farms, without the use of antibiotics and/or antiseptics.

Paper on chronic wounds, based on scientific experiments on cellular and molecular studies and clinical observations demonstrating how Polyactil Gel and Petroactil manage reactivation of chronic wounds and revert non-healing to a complete reactivation leading to morphogenetic healing.

International publication. Article published in December 2002, in the journal Archives of Surgery, by invitation: Surgery in Costa Rica.

The article covers the history of surgery in Costa Rica, development of surgery and access of population to surgery prior and after birth of National Health System, present surgical facilities, review of categories of more specialized surgeries performed, incidence of surgical site infection, surgical mortality, graduate programs and surgical research.

Other areas of research

A series of themes dealing with resolution of chronic inflammation, mucosal barrier strengthening and surface science inter-talk between mucosal surfaces and epithelial cells are being designed by Dr. Feoli and are meant to develop other products that will deal hard to resolve medical problems.

Medical directorship of scientific and medical research

Since 1995 Dr. Feoli has lead the effort in conceiving the principles and designing pharmaceutical prototypes that have reached the stage of pre-clinical and clinical verification for a whole family of products to be launched to market. Bioacyl Corp. and medACTIL, Ltda. have jointly undertaken such effort. The culmination of this process has opened the door for Polyactil gel reaching the stage where it can obtain GRAS status in the US and its active principle,

In view of aforementioned, Polyactil Buffer becoming a candidate to the registered in the US Pharmacopoeia.