Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
Christopher R M Asquith
1, 2, 3, 4, 5, 6
,
Tuomo Laitinen
7, 8
,
Lidia S. Konstantinova
9, 10, 11, 12
,
G. J. Tizzard
13
,
Graham Tizzard
14
,
Antti Poso
7, 8
,
Oleg A. Rakitin
9, 10, 11, 12
,
Regina Hofmann-Lehmann
2, 5
,
STEPHEN HILTON
1, 4
6
Current address: Department of Pharmacology School of Medicine University of North Carolina at Chapel Hill 120 Mason Farm Road, Genetic Medicine Building Chapel Hill NC 27599 USA
|
8
9
11
Тип публикации: Journal Article
Дата публикации: 2019-01-25
scimago Q1
wos Q2
БС2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
PubMed ID:
30609219
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
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14
Всего цитирований:
14
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5
(35%)
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ГОСТ
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Asquith C. R. M. et al. Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection // ChemMedChem. 2019. Vol. 14. No. 4. pp. 454-461.
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Asquith C. R. M., Laitinen T., Konstantinova L. S., Tizzard G. J., Tizzard G., Poso A., Rakitin O. A., Hofmann-Lehmann R., HILTON S. Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection // ChemMedChem. 2019. Vol. 14. No. 4. pp. 454-461.
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RIS
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TY - JOUR
DO - 10.1002/cmdc.201800718
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201800718
TI - Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
T2 - ChemMedChem
AU - Asquith, Christopher R M
AU - Laitinen, Tuomo
AU - Konstantinova, Lidia S.
AU - Tizzard, G. J.
AU - Tizzard, Graham
AU - Poso, Antti
AU - Rakitin, Oleg A.
AU - Hofmann-Lehmann, Regina
AU - HILTON, STEPHEN
PY - 2019
DA - 2019/01/25
PB - Wiley
SP - 454-461
IS - 4
VL - 14
PMID - 30609219
SN - 1860-7179
SN - 1860-7187
ER -
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BibTex (до 50 авторов)
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@article{2019_Asquith,
author = {Christopher R M Asquith and Tuomo Laitinen and Lidia S. Konstantinova and G. J. Tizzard and Graham Tizzard and Antti Poso and Oleg A. Rakitin and Regina Hofmann-Lehmann and STEPHEN HILTON},
title = {Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection},
journal = {ChemMedChem},
year = {2019},
volume = {14},
publisher = {Wiley},
month = {jan},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201800718},
number = {4},
pages = {454--461},
doi = {10.1002/cmdc.201800718}
}
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MLA
Скопировать
Asquith, Christopher R. M., et al. “Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection.” ChemMedChem, vol. 14, no. 4, Jan. 2019, pp. 454-461. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201800718.
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