A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid-β Fragment with Taiwanese Mutation D7H

Polshakov V.I., Mantsyzov A.B., Kozin S.A., Adzhubei A.A., Zhokhov S.S., van Beek W., Kulikova A.A., Indeykina M.I., Mitkevich V.A., Makarov A.A.
Тип документаJournal Article
Дата публикации2017-09-18
Название журналаAngewandte Chemie - International Edition
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 202116.82
ISSN14337851, 15213773
General Chemistry
Краткое описание
Zinc-induced oligomerization of amyloid-β peptide (Aβ) produces potentially pathogenic agents of Alzheimer's disease. Mutations and modifications in the metal binding domain 1-16 of Aβ peptide crucially affect its zinc-induced oligomerization by changing intermolecular zinc mediated interface. The 3D structure of this interface appearing in a range of Aβ species is a prospective drug target for disease modifying therapy. Using NMR spectroscopy, EXAFS spectroscopy, mass spectrometry, and isothermal titration calorimetry the interaction of zinc ions with Aβ fragments 1-7 and 1-10 carrying familial Taiwanese mutation D7H was studied. Zinc ions induce formation of a stable homodimer formed by the two peptide chains fastened by two zinc ions and stacking interactions of imidazole rings. A binuclear zinc interaction fold in the dimer structure was discovered. It can be used for designing zinc-regulated proteins and zinc-mediated self-assembling peptides.
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1. Polshakov V.I. и др. A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer’s Amyloid-β Fragment with Taiwanese Mutation D7H // Angewandte Chemie International Edition. 2017. Т. 56. № 39. С. 11734–11739.


DO - 10.1002/anie.201704615

UR - http://dx.doi.org/10.1002/anie.201704615

TI - A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid-β Fragment with Taiwanese Mutation D7H

T2 - Angewandte Chemie International Edition

AU - Polshakov, Vladimir I.

AU - Mantsyzov, Alexey B.

AU - Kozin, Sergey A.

AU - Adzhubei, Alexei A.

AU - Zhokhov, Sergey S.

AU - van Beek, Wouter

AU - Kulikova, Alexandra A.

AU - Indeykina, Maria I.

AU - Mitkevich, Vladimir A.

AU - Makarov, Alexander A.

PY - 2017

DA - 2017/06/27

PB - Wiley

SP - 11734-11739

IS - 39

VL - 56

SN - 1433-7851

ER -

BibTex |


doi = {10.1002/anie.201704615},

url = {https://doi.org/10.1002%2Fanie.201704615},

year = 2017,

month = {jun},

publisher = {Wiley},

volume = {56},

number = {39},

pages = {11734--11739},

author = {Vladimir I. Polshakov and Alexey B. Mantsyzov and Sergey A. Kozin and Alexei A. Adzhubei and Sergey S. Zhokhov and Wouter van{\hspace{0.25em}}Beek and Alexandra A. Kulikova and Maria I. Indeykina and Vladimir A. Mitkevich and Alexander A. Makarov},

title = {A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer{\textquotesingle}s Amyloid-$\upbeta$ Fragment with Taiwanese Mutation D7H}


Polshakov, Vladimir I. et al. “A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer’s Amyloid-β Fragment with Taiwanese Mutation D7H.” Angewandte Chemie International Edition 56.39 (2017): 11734–11739. Crossref. Web.