Click Chemistry: 1,2,3-Triazoles as Pharmacophores
Publication type: Journal Article
Publication date: 2011-08-29
scimago Q2
wos Q2
SJR: 0.751
CiteScore: 5.9
Impact factor: 3.3
ISSN: 18614728, 1861471X
PubMed ID:
21954075
General Chemistry
Organic Chemistry
Biochemistry
Abstract
The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
10
20
30
40
50
60
|
|
|
European Journal of Medicinal Chemistry
57 publications, 4.93%
|
|
|
RSC Advances
47 publications, 4.07%
|
|
|
ChemistrySelect
44 publications, 3.81%
|
|
|
Organic Letters
34 publications, 2.94%
|
|
|
Molecules
33 publications, 2.85%
|
|
|
Organic and Biomolecular Chemistry
30 publications, 2.6%
|
|
|
European Journal of Organic Chemistry
29 publications, 2.51%
|
|
|
Tetrahedron Letters
27 publications, 2.34%
|
|
|
Journal of Organic Chemistry
26 publications, 2.25%
|
|
|
Journal of Molecular Structure
26 publications, 2.25%
|
|
|
Bioorganic and Medicinal Chemistry Letters
25 publications, 2.16%
|
|
|
Tetrahedron
18 publications, 1.56%
|
|
|
Applied Organometallic Chemistry
18 publications, 1.56%
|
|
|
Synlett
18 publications, 1.56%
|
|
|
Bioorganic Chemistry
16 publications, 1.38%
|
|
|
Advanced Synthesis and Catalysis
16 publications, 1.38%
|
|
|
Journal of Heterocyclic Chemistry
16 publications, 1.38%
|
|
|
Chemistry - A European Journal
15 publications, 1.3%
|
|
|
Chemical Communications
15 publications, 1.3%
|
|
|
New Journal of Chemistry
15 publications, 1.3%
|
|
|
Synthetic Communications
15 publications, 1.3%
|
|
|
Synthesis
15 publications, 1.3%
|
|
|
Angewandte Chemie
13 publications, 1.12%
|
|
|
Angewandte Chemie - International Edition
13 publications, 1.12%
|
|
|
Medicinal Chemistry Research
12 publications, 1.04%
|
|
|
Carbohydrate Research
12 publications, 1.04%
|
|
|
Asian Journal of Organic Chemistry
11 publications, 0.95%
|
|
|
Journal of the American Chemical Society
11 publications, 0.95%
|
|
|
Bioorganic and Medicinal Chemistry
10 publications, 0.87%
|
|
|
10
20
30
40
50
60
|
Publishers
|
50
100
150
200
250
300
|
|
|
Elsevier
285 publications, 24.65%
|
|
|
Wiley
247 publications, 21.37%
|
|
|
Royal Society of Chemistry (RSC)
152 publications, 13.15%
|
|
|
American Chemical Society (ACS)
121 publications, 10.47%
|
|
|
Springer Nature
87 publications, 7.53%
|
|
|
MDPI
71 publications, 6.14%
|
|
|
Taylor & Francis
45 publications, 3.89%
|
|
|
Georg Thieme Verlag KG
35 publications, 3.03%
|
|
|
Pleiades Publishing
26 publications, 2.25%
|
|
|
Bentham Science Publishers Ltd.
20 publications, 1.73%
|
|
|
Beilstein-Institut
6 publications, 0.52%
|
|
|
The Japan Institute of Heterocyclic Chemistry
6 publications, 0.52%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
5 publications, 0.43%
|
|
|
Shanghai Institute of Organic Chemistry
4 publications, 0.35%
|
|
|
Walter de Gruyter
4 publications, 0.35%
|
|
|
International Union of Crystallography (IUCr)
3 publications, 0.26%
|
|
|
The Royal Society
3 publications, 0.26%
|
|
|
Frontiers Media S.A.
3 publications, 0.26%
|
|
|
King Saud University
3 publications, 0.26%
|
|
|
CSIRO Publishing
2 publications, 0.17%
|
|
|
World Scientific
2 publications, 0.17%
|
|
|
Pharmaceutical Society of Korea
2 publications, 0.17%
|
|
|
Public Library of Science (PLoS)
2 publications, 0.17%
|
|
|
Academia Brasileira de Ciencias
2 publications, 0.17%
|
|
|
Asian Journal of Chemistry
2 publications, 0.17%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
2 publications, 0.17%
|
|
|
AIP Publishing
1 publication, 0.09%
|
|
|
IOP Publishing
1 publication, 0.09%
|
|
|
Cellule MathDoc/Centre Mersenne
1 publication, 0.09%
|
|
|
50
100
150
200
250
300
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
1.2k
Total citations:
1156
Citations from 2024:
124
(10.73%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Agalave S. G., Maujan S. R., Pore V. S. Click Chemistry: 1,2,3-Triazoles as Pharmacophores // Chemistry - An Asian Journal. 2011. Vol. 6. No. 10. pp. 2696-2718.
GOST all authors (up to 50)
Copy
Agalave S. G., Maujan S. R., Pore V. S. Click Chemistry: 1,2,3-Triazoles as Pharmacophores // Chemistry - An Asian Journal. 2011. Vol. 6. No. 10. pp. 2696-2718.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/asia.201100432
UR - https://doi.org/10.1002/asia.201100432
TI - Click Chemistry: 1,2,3-Triazoles as Pharmacophores
T2 - Chemistry - An Asian Journal
AU - Agalave, Sandip G
AU - Maujan, Suleman R
AU - Pore, Vandana S
PY - 2011
DA - 2011/08/29
PB - Wiley
SP - 2696-2718
IS - 10
VL - 6
PMID - 21954075
SN - 1861-4728
SN - 1861-471X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Agalave,
author = {Sandip G Agalave and Suleman R Maujan and Vandana S Pore},
title = {Click Chemistry: 1,2,3-Triazoles as Pharmacophores},
journal = {Chemistry - An Asian Journal},
year = {2011},
volume = {6},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/asia.201100432},
number = {10},
pages = {2696--2718},
doi = {10.1002/asia.201100432}
}
Cite this
MLA
Copy
Agalave, Sandip G., et al. “Click Chemistry: 1,2,3-Triazoles as Pharmacophores.” Chemistry - An Asian Journal, vol. 6, no. 10, Aug. 2011, pp. 2696-2718. https://doi.org/10.1002/asia.201100432.