Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate
Тип публикации: Journal Article
Дата публикации: 2008-05-05
scimago Q1
wos Q3
white level БС2
SJR: 0.844
CiteScore: 5.2
Impact factor: 2.8
ISSN: 14394227, 14397633
PubMed ID:
18351684
Organic Chemistry
Biochemistry
Molecular Biology
Molecular Medicine
Краткое описание
Quinonoid intermediates play a key role in the catalytic mechanism of pyridoxal 5'-phosphate (PLP)-dependent enzymes. Whereas structures of other PLP-bound reaction intermediates have been determined, a high-quality structure of a quinonoid species has not been reported. We present the crystal structure of the indoline quinonoid intermediate of tryptophan synthase (see figure) and discuss its implications for the enzymatic mechanism and allosteric regulation.
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ГОСТ
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Barends T. R. M. et al. Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate // ChemBioChem. 2008. Vol. 9. No. 7. pp. 1024-1028.
ГОСТ со всеми авторами (до 50)
Скопировать
Barends T. R. M., Domratcheva T., Kulik V., Blumenstein L., Niks D., Dunn M. F., Schlichting I. Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate // ChemBioChem. 2008. Vol. 9. No. 7. pp. 1024-1028.
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TY - JOUR
DO - 10.1002/cbic.200700703
UR - https://doi.org/10.1002/cbic.200700703
TI - Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate
T2 - ChemBioChem
AU - Barends, Thomas R. M.
AU - Domratcheva, Tatiana
AU - Kulik, Victor
AU - Blumenstein, Lars
AU - Niks, Dimitri
AU - Dunn, Michael F.
AU - Schlichting, Ilme
PY - 2008
DA - 2008/05/05
PB - Wiley
SP - 1024-1028
IS - 7
VL - 9
PMID - 18351684
SN - 1439-4227
SN - 1439-7633
ER -
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BibTex (до 50 авторов)
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@article{2008_Barends,
author = {Thomas R. M. Barends and Tatiana Domratcheva and Victor Kulik and Lars Blumenstein and Dimitri Niks and Michael F. Dunn and Ilme Schlichting},
title = {Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate},
journal = {ChemBioChem},
year = {2008},
volume = {9},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/cbic.200700703},
number = {7},
pages = {1024--1028},
doi = {10.1002/cbic.200700703}
}
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MLA
Скопировать
Barends, Thomas R. M., et al. “Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate.” ChemBioChem, vol. 9, no. 7, May. 2008, pp. 1024-1028. https://doi.org/10.1002/cbic.200700703.
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