Chemistry - A European Journal, volume 28, issue 67
Hydrophilic Chitosan Derivatives: Synthesis and Applications
Publication type: Journal Article
Publication date: 2022-10-06
Journal:
Chemistry - A European Journal
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.3
ISSN: 09476539, 15213765
General Chemistry
Catalysis
Organic Chemistry
Abstract
Polymer alternatives sourced from nature have attracted increasing attention for applications in medicine, cosmetics, agriculture, food, water purification, and more. Among them, chitosan is the most versatile due to its full biodegradability, exceptional biocompatibility, multipurpose bioactivity, and low toxicity. Although remarkable progress has been made in its synthetic modification by using C3/C6 secondary/primary hydroxy (-OH) and the C2 amino (-NH2 ) active sites, its solubility under physiological conditions remains limited and has hampered larger-scale adoption. This review summarizes different synthetic methods that increase chitosan's hydrophilicity and water solubility by using covalent modifications, namely amino acid addition, quaternary ammonium formation, phosphorylation, and carboxymethylation. We also review several applications for each type of substitution in fields such as cosmetics, medicine, agriculture, and water purification, and provide an outlook and perspective for future modifications and implementations.
Top-30
Citations by journals
|
1
|
|
|
ACS Biomaterials Science and Engineering
1 publication, 5.56%
|
|
|
Small Methods
1 publication, 5.56%
|
|
|
Molecules
1 publication, 5.56%
|
|
|
Advanced Functional Materials
1 publication, 5.56%
|
|
|
Chemistry of Materials
1 publication, 5.56%
|
|
|
Foods
1 publication, 5.56%
|
|
|
International Journal of Molecular Sciences
1 publication, 5.56%
|
|
|
ChemNanoMat
1 publication, 5.56%
|
|
|
Pharmaceutics
1 publication, 5.56%
|
|
|
Chemosphere
1 publication, 5.56%
|
|
|
Russian Chemical Reviews
1 publication, 5.56%
|
|
|
EngMedicine
1 publication, 5.56%
|
|
|
Starch/Staerke
1 publication, 5.56%
|
|
|
International Journal of Biological Macromolecules
1 publication, 5.56%
|
|
|
Journal of Food Science
1 publication, 5.56%
|
|
|
Journal of Functional Biomaterials
1 publication, 5.56%
|
|
|
Gels
1 publication, 5.56%
|
|
|
1
|
Citations by publishers
|
1
2
3
4
5
6
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
6 publications, 33.33%
|
|
|
Wiley
5 publications, 27.78%
|
|
|
Elsevier
4 publications, 22.22%
|
|
|
American Chemical Society (ACS)
2 publications, 11.11%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 5.56%
|
|
|
1
2
3
4
5
6
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2023,2024],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[3,15],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["16.67","83.33"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["ACS Biomaterials Science and Engineering","Small Methods","Molecules","Advanced Functional Materials","Chemistry of Materials","Foods","International Journal of Molecular Sciences","ChemNanoMat","Pharmaceutics","Chemosphere","Russian Chemical Reviews","EngMedicine","Starch\/Staerke","International Journal of Biological Macromolecules","Journal of Food Science","Journal of Functional Biomaterials","Gels"],"ids":[19167,4145,1770,7715,6428,11536,14627,15836,4502,22418,23802,64588,12800,23035,16815,19043,16915],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56,5.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Wiley","Elsevier","American Chemical Society (ACS)","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii"],"ids":[202,11,17,40,9422],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[6,5,4,2,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,27.78,22.22,11.11,5.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0],"percentage":["0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0],"percentage":["0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,3],"percentage":["0","16.67"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[3,10],"percentage":["16.67","55.56"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,2],"percentage":["0","11.11"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0],"percentage":["0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,1],"percentage":["0","5.56"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[2,3],"percentage":["11.11","16.67"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,9],"percentage":["5.56","50"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,2],"percentage":["0","11.11"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Cohen E., Poverenov E. Hydrophilic Chitosan Derivatives: Synthesis and Applications // Chemistry - A European Journal. 2022. Vol. 28. No. 67.
GOST all authors (up to 50)
Copy
Cohen E., Poverenov E. Hydrophilic Chitosan Derivatives: Synthesis and Applications // Chemistry - A European Journal. 2022. Vol. 28. No. 67.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/chem.202202156
UR - https://doi.org/10.1002/chem.202202156
TI - Hydrophilic Chitosan Derivatives: Synthesis and Applications
T2 - Chemistry - A European Journal
AU - Cohen, Erez
AU - Poverenov, Elena
PY - 2022
DA - 2022/10/06 00:00:00
PB - Wiley
IS - 67
VL - 28
SN - 0947-6539
SN - 1521-3765
ER -
Cite this
BibTex
Copy
@article{2022_Cohen,
author = {Erez Cohen and Elena Poverenov},
title = {Hydrophilic Chitosan Derivatives: Synthesis and Applications},
journal = {Chemistry - A European Journal},
year = {2022},
volume = {28},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1002/chem.202202156},
number = {67},
doi = {10.1002/chem.202202156}
}