Wiley
ChemMedChem
,  volume 11 ,  issue 19 ,  pages 2119-2126

Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism

Christopher R M Asquith 1, 2, 3, 4
, 
Lidia S. Konstantinova 5, 6, 7, 8
, 
Tuomo Laitinen 9
, 
Marina L. Meli 2, 4
, 
Antti Poso 10
, 
Oleg A. Rakitin 5, 6, 7, 8
, 
Regina Hofmann-Lehmann 2, 4
, 
STEPHEN HILTON 1, 3
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
10
 
Publication type: Journal Article
Publication date: 2016-08-11
Wiley
scimago Q1
wos Q2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract

A diverse library of 5‐thieno‐, 5‐oxo‐, and 5‐imino‐1,2,3‐dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.

Found 
Found 
3 citations
Lyssenko Konstantin
🥼 🤝
DSc in Chemistry, professor
898 publications,  15 140 citations,  2 reviews
h-index: 50
Lomonosov Moscow State University
Lomonosov Moscow State University
National Research University Higher School of Economics
National Research University Higher School of Economics
Research interests
Supramolecular chemistry
1 citation
Fershtat Leonid
DSc in Chemistry
146 publications,  2 959 citations,  121 reviews
h-index: 29
N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences
N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences
Research interests
Materials Science
Medicinal Chemistry
Organic Chemistry
1 citation
Tsaplin Grigory
🥼 🤝
10 publications,  31 citations
h-index: 4
Mendeleev University of Chemical Technology of Russia
Mendeleev University of Chemical Technology of Russia
Research interests
(alpha,n) reactions
Agrochemistry
Heterocyclic compounds
Medicinal Chemistry
Organic Chemistry
Organic synthesis
Synthesis of biologically active substances

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GOST Copy
Asquith C. R. M. et al. Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism // ChemMedChem. 2016. Vol. 11. No. 19. pp. 2119-2126.
GOST all authors (up to 50) Copy
Asquith C. R. M., Konstantinova L. S., Laitinen T., Meli M. L., Poso A., Rakitin O. A., Hofmann-Lehmann R., HILTON S. Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism // ChemMedChem. 2016. Vol. 11. No. 19. pp. 2119-2126.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/cmdc.201600260
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201600260
TI - Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism
T2 - ChemMedChem
AU - Asquith, Christopher R M
AU - Konstantinova, Lidia S.
AU - Laitinen, Tuomo
AU - Meli, Marina L.
AU - Poso, Antti
AU - Rakitin, Oleg A.
AU - Hofmann-Lehmann, Regina
AU - HILTON, STEPHEN
PY - 2016
DA - 2016/08/11
PB - Wiley
SP - 2119-2126
IS - 19
VL - 11
PMID - 27511289
SN - 1860-7179
SN - 1860-7187
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2016_Asquith,
author = {Christopher R M Asquith and Lidia S. Konstantinova and Tuomo Laitinen and Marina L. Meli and Antti Poso and Oleg A. Rakitin and Regina Hofmann-Lehmann and STEPHEN HILTON},
title = {Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism},
journal = {ChemMedChem},
year = {2016},
volume = {11},
publisher = {Wiley},
month = {aug},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201600260},
number = {19},
pages = {2119--2126},
doi = {10.1002/cmdc.201600260}
}
MLA
Cite this
MLA Copy
Asquith, Christopher R. M., et al. “Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism.” ChemMedChem, vol. 11, no. 19, Aug. 2016, pp. 2119-2126. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201600260.