Wiley
ChemMedChem
,  volume 14 ,  issue 4 ,  pages 454-461

Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection

Christopher R M Asquith 1, 2, 3, 4, 5, 6
, 
Tuomo Laitinen 7, 8
, 
Lidia S. Konstantinova 9, 10, 11, 12
, 
G. J. Tizzard 13
, 
Graham Tizzard 14
, 
Antti Poso 7, 8
, 
Oleg A. Rakitin 9, 10, 11, 12
, 
Regina Hofmann-Lehmann 2, 5
, 
STEPHEN HILTON 1, 4
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Publication type: Journal Article
Publication date: 2019-01-25
Wiley
scimago Q1
wos Q2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract

A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.

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GOST |
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GOST Copy
Asquith C. R. M. et al. Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection // ChemMedChem. 2019. Vol. 14. No. 4. pp. 454-461.
GOST all authors (up to 50) Copy
Asquith C. R. M., Laitinen T., Konstantinova L. S., Tizzard G. J., Tizzard G., Poso A., Rakitin O. A., Hofmann-Lehmann R., HILTON S. Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection // ChemMedChem. 2019. Vol. 14. No. 4. pp. 454-461.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/cmdc.201800718
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201800718
TI - Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
T2 - ChemMedChem
AU - Asquith, Christopher R M
AU - Laitinen, Tuomo
AU - Konstantinova, Lidia S.
AU - Tizzard, G. J.
AU - Tizzard, Graham
AU - Poso, Antti
AU - Rakitin, Oleg A.
AU - Hofmann-Lehmann, Regina
AU - HILTON, STEPHEN
PY - 2019
DA - 2019/01/25
PB - Wiley
SP - 454-461
IS - 4
VL - 14
PMID - 30609219
SN - 1860-7179
SN - 1860-7187
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Asquith,
author = {Christopher R M Asquith and Tuomo Laitinen and Lidia S. Konstantinova and G. J. Tizzard and Graham Tizzard and Antti Poso and Oleg A. Rakitin and Regina Hofmann-Lehmann and STEPHEN HILTON},
title = {Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection},
journal = {ChemMedChem},
year = {2019},
volume = {14},
publisher = {Wiley},
month = {jan},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201800718},
number = {4},
pages = {454--461},
doi = {10.1002/cmdc.201800718}
}
MLA
Cite this
MLA Copy
Asquith, Christopher R. M., et al. “Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection.” ChemMedChem, vol. 14, no. 4, Jan. 2019, pp. 454-461. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201800718.