Synthesis, Structures and Antifungal Activity of Selenoglycolurils
Pavel G. Baranov
1
,
Karl A Hansford
2
,
Louise I. M. Friberg
2
,
Elena D. Strel'tzova
1
,
E. S. Lipatov
3
,
Publication type: Journal Article
Publication date: 2023-04-07
General Chemistry
Abstract
A synthetic method for the preparation of selenoglycolurils is reported. Target compounds were obtained by two‐stage transformation of unsubstituted, 1‐substituted and 1,3‐disubstituted thioglycolurils by S‐methylation with MeI to the corresponding isothiouronium salts (Step 1) followed by selenation with NaHSe generated in situ from grey Se and NaBH4 (Step 2). Selenoglycolurils possessed potent antifungal activity against Candida albicans and Cryptococcus neoformans (MIC 0.25–0.125 μg/mL) with no discernable toxicity against mamallian cells, supporting the unique role of organoselenium compounds as novel antifungal agents.
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9
Total citations:
9
Citations from 2025:
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(33.33%)
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Galochkin A. A. et al. Synthesis, Structures and Antifungal Activity of Selenoglycolurils // ChemistrySelect. 2023. Vol. 8. No. 14. e202300765
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Galochkin A. A., Baranov P. G., Baranov V. V., Hansford K. A., Friberg L. I. M., Strel'tzova E. D., Lipatov E. S., Nelyubina Y. V., Kravchenko A. N. Synthesis, Structures and Antifungal Activity of Selenoglycolurils // ChemistrySelect. 2023. Vol. 8. No. 14. e202300765
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TY - JOUR
DO - 10.1002/slct.202300765
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202300765
TI - Synthesis, Structures and Antifungal Activity of Selenoglycolurils
T2 - ChemistrySelect
AU - Galochkin, Anton A
AU - Baranov, Pavel G.
AU - Baranov, Vladimir V
AU - Hansford, Karl A
AU - Friberg, Louise I. M.
AU - Strel'tzova, Elena D.
AU - Lipatov, E. S.
AU - Nelyubina, Yulia V.
AU - Kravchenko, Angelina N.
PY - 2023
DA - 2023/04/07
PB - Wiley
IS - 14
VL - 8
SN - 2365-6549
ER -
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@article{2023_Galochkin,
author = {Anton A Galochkin and Pavel G. Baranov and Vladimir V Baranov and Karl A Hansford and Louise I. M. Friberg and Elena D. Strel'tzova and E. S. Lipatov and Yulia V. Nelyubina and Angelina N. Kravchenko},
title = {Synthesis, Structures and Antifungal Activity of Selenoglycolurils},
journal = {ChemistrySelect},
year = {2023},
volume = {8},
publisher = {Wiley},
month = {apr},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202300765},
number = {14},
pages = {e202300765},
doi = {10.1002/slct.202300765}
}