Basic equations and uncertainties in isotope-dilution mass spectrometry for traceability to SI of values obtained by this primary method

A current interest in chemistry concerns traceability of analytical measurements to the International System of Units (SI) and the estimation of their uncertainties in accordance with principles of metrology, that is, measurement science. “Primary methods of measurement” achieve traceability to SI directly without intermediate reference standards or materials and without significant empirical correction factors. Isotope-dilution mass spectrometry should be regarded as such a method. It has the potential of smallest presently achievable uncertainties for analytical measurements directly or for the certification of reference materials including those with abnormal isotopic composition. A simple explanation of the method including its basic equations is given. Full uncertainty estimation is emphasized in terms of these equations. The wider use of concepts of metrology in chemistry is discussed.