Metabolomics, volume 15, issue 3, publication number 29

Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

Yanshole Vadim V ^{1, 2}

Yanshole Lyudmila V ^{1, 2}

Snytnikova Olga A ^{1, 2}

Tsentalovich Yuri P ^{1, 2}

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International Tomography Center SB RAS, Novosibirsk, Russia |

Novosibirsk state University, Novosibirsk, Russia |

Publication type: Journal Article

Publication date: 2019-02-26

Springer Nature

Journal: Metabolomics

Quartile SCImago

Quartile WOS

Impact factor: 3.6

ISSN: 15733882, 15733890

DOI: 10.1007/s11306-019-1495-4

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Biochemistry

Clinical Biochemistry

Endocrinology, Diabetes and Metabolism

Abstract

Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters are especially important for the lens protection, and their lack may cause the development of ophthalmic diseases. Comparison of the metabolomic compositions of lenses and AH taken from cataract patients with that taken from human cadavers without cataract can shed light onto molecular mechanisms underlying onset of age-related nuclear cataract. Combined use of 1H nuclear magnetic resonance and high performance liquid chromatography with optical and high-resolution mass spectrometric detection for the identification and quantification of metabolites in the lens and AH extracts. The concentrations of 86 metabolites were determined for four groups of samples, including lenses and AH from cataract patients and from human cadavers. In cataractous lens the most abundant metabolites are (in descending order): myo-inositol, lactate, acetate, glutamate, glutathione; in AH—lactate, glucose, glutamine, alanine, valine. The concentrations of the majority of metabolites in normal post-mortem samples of both lens and AH are higher than that in samples from the cataract patients. Comparison of metabolite concentrations in lens and corresponding AH reveal that the most important for the lens protection metabolites are synthesized in the lens epithelial cells. The reduced levels of antioxidants, UV filters, and osmolytes were found in the cataractous lenses what cannot be explained by post-mortem changes in normal lens; that indicates that the age-related nuclear cataract development may originate from the dysfunction of the lens epithelial cells.

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Citations by journals

	1 2 3 4
Metabolites	Metabolites, 4, 12.12% Metabolites 4 publications, 12.12%
Experimental Eye Research	Experimental Eye Research, 3, 9.09% Experimental Eye Research 3 publications, 9.09%
Scientific Reports	Scientific Reports, 2, 6.06% Scientific Reports 2 publications, 6.06%
Metabolomics	Metabolomics, 2, 6.06% Metabolomics 2 publications, 6.06%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 6.06% International Journal of Molecular Sciences 2 publications, 6.06%
Biology	Biology, 2, 6.06% Biology 2 publications, 6.06%
Investigative Ophthalmology and Visual Science	Investigative Ophthalmology and Visual Science, 1, 3.03% Investigative Ophthalmology and Visual Science 1 publication, 3.03%
EPMA Journal	EPMA Journal, 1, 3.03% EPMA Journal 1 publication, 3.03%
Antioxidants	Antioxidants, 1, 3.03% Antioxidants 1 publication, 3.03%
Cells	Cells, 1, 3.03% Cells 1 publication, 3.03%
Stem Cell Reviews and Reports	Stem Cell Reviews and Reports, 1, 3.03% Stem Cell Reviews and Reports 1 publication, 3.03%
Analytical Biochemistry	Analytical Biochemistry, 1, 3.03% Analytical Biochemistry 1 publication, 3.03%
Free Radical Biology and Medicine	Free Radical Biology and Medicine, 1, 3.03% Free Radical Biology and Medicine 1 publication, 3.03%
RSC Advances	RSC Advances, 1, 3.03% RSC Advances 1 publication, 3.03%
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 1, 3.03% Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 1 publication, 3.03%
Biomeditsinskaya Khimiya	Biomeditsinskaya Khimiya, 1, 3.03% Biomeditsinskaya Khimiya 1 publication, 3.03%
eLife	eLife, 1, 3.03% eLife 1 publication, 3.03%
South of Russia: Ecology, Development	South of Russia: Ecology, Development, 1, 3.03% South of Russia: Ecology, Development 1 publication, 3.03%
Experimental and Therapeutic Medicine	Experimental and Therapeutic Medicine, 1, 3.03% Experimental and Therapeutic Medicine 1 publication, 3.03%
Journal of Alzheimer's Disease	Journal of Alzheimer's Disease, 1, 3.03% Journal of Alzheimer's Disease 1 publication, 3.03%
Advances in Gerontology	Advances in Gerontology, 1, 3.03% Advances in Gerontology 1 publication, 3.03%
	1 2 3 4

Citations by publishers

	2 4 6 8 10
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 10, 30.3% Multidisciplinary Digital Publishing Institute (MDPI) 10 publications, 30.3%
Springer Nature	Springer Nature, 6, 18.18% Springer Nature 6 publications, 18.18%
Elsevier	Elsevier, 5, 15.15% Elsevier 5 publications, 15.15%
Pleiades Publishing	Pleiades Publishing, 2, 6.06% Pleiades Publishing 2 publications, 6.06%
Association for Research in Vision and Ophthalmology (ARVO)	Association for Research in Vision and Ophthalmology (ARVO), 1, 3.03% Association for Research in Vision and Ophthalmology (ARVO) 1 publication, 3.03%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 3.03% Royal Society of Chemistry (RSC) 1 publication, 3.03%
V. N. Orekhovich Research Institute of Biomedical Chemistry	V. N. Orekhovich Research Institute of Biomedical Chemistry, 1, 3.03% V. N. Orekhovich Research Institute of Biomedical Chemistry 1 publication, 3.03%
eLife Sciences Publications	eLife Sciences Publications, 1, 3.03% eLife Sciences Publications 1 publication, 3.03%
Kamerton	Kamerton, 1, 3.03% Kamerton 1 publication, 3.03%
Spandidos Publications	Spandidos Publications, 1, 3.03% Spandidos Publications 1 publication, 3.03%
IOS Press	IOS Press, 1, 3.03% IOS Press 1 publication, 3.03%
	2 4 6 8 10

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Yanshole V. V. et al. Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract // Metabolomics. 2019. Vol. 15. No. 3. 29

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Yanshole V. V., Yanshole L. V., Snytnikova O. A., Tsentalovich Y. P. Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract // Metabolomics. 2019. Vol. 15. No. 3. 29

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TY - JOUR

DO - 10.1007/s11306-019-1495-4

UR - https://doi.org/10.1007%2Fs11306-019-1495-4

TI - Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

T2 - Metabolomics

AU - Yanshole, Vadim V

AU - Yanshole, Lyudmila V

AU - Snytnikova, Olga A

AU - Tsentalovich, Yuri P

PY - 2019

DA - 2019/02/26 00:00:00

PB - Springer Nature

IS - 3

VL - 15

SN - 1573-3882

SN - 1573-3890

ER -

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BibTex Copy

@article{2019_Yanshole,

author = {Vadim V Yanshole and Lyudmila V Yanshole and Olga A Snytnikova and Yuri P Tsentalovich},

title = {Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract},

journal = {Metabolomics},

year = {2019},

volume = {15},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1007%2Fs11306-019-1495-4},

number = {3},

doi = {10.1007/s11306-019-1495-4}

}

Found error?

Publisher

Springer Nature

Journal

Metabolomics

Quartile SCImago

Quartile WOS

Impact factor

3.6

ISSN

15733882 (Print)
15733890 (Electronic)

Labs

Laboratory of Proteomics and Metabolomics

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